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Altered white matter microstructure in adolescents with major depression: a preliminary study.

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Title: Altered white matter microstructure in adolescents with major depression: a preliminary study.
Authors: Cullen KR (AUTHOR), Klimes-Dougan B (AUTHOR), Muetzel R (AUTHOR), Mueller BA (AUTHOR), Camchong J (AUTHOR), Houri A (AUTHOR), Kurma S (AUTHOR), Lim KO (AUTHOR), Cullen, Kathryn R1 (AUTHOR), Klimes-Dougan, Bonnie (AUTHOR), Muetzel, Ryan (AUTHOR), Mueller, Bryon A (AUTHOR), Camchong, Jazmin (AUTHOR), Houri, Alaa (AUTHOR), Kurma, Sanjiv (AUTHOR), Lim, Kelvin O (AUTHOR)
Source: Journal of the American Academy of Child & Adolescent Psychiatry. Feb2010, Vol. 49 Issue 2, p173-183e1. 1p.
Abstract: Objective: Major depressive disorder (MDD) occurs frequently in adolescents, but the neurobiology of depression in youth is poorly understood. Structural neuroimaging studies in both adult and pediatric populations have implicated frontolimbic neural networks in the pathophysiology of MDD. Diffusion tensor imaging (DTI), which measures white matter (WM) microstructure, is a promising tool for examining neural connections and how they may be abnormal in MDD.Method: We used two separate approaches to analyze DTI data in adolescents with MDD (n = 14) compared with healthy volunteers (n = 14).Results: The first, hypothesis-driven approach was to use probabilistic tractography to delineate tracts arising from the subgenual anterior cingulate cortex (ACC). Adolescents with MDD demonstrated lower fractional anisotropy (FA) in the WM tract connecting subgenual ACC to amygdala in the right hemisphere. The second, exploratory approach was to conduct a voxelwise comparison of FA. This analysis revealed 10 clusters where adolescents with MDD had significantly lower (uncorrected) FA than the healthy group within WM tracts including right and left uncinate and supragenual cingulum.Conclusions: These preliminary data support the hypothesis that altered WM microstructure in frontolimbic neural pathways may contribute to the pathophysiology of MDD in adolescents. [ABSTRACT FROM AUTHOR]
Copyright of Journal of the American Academy of Child & Adolescent Psychiatry is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Education Research Complete
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DbLabel: Education Research Complete
An: 105143464
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Altered white matter microstructure in adolescents with major depression: a preliminary study.
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  Data: <searchLink fieldCode="AR" term="%22Cullen+KR%22">Cullen KR</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Klimes-Dougan+B%22">Klimes-Dougan B</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Muetzel+R%22">Muetzel R</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mueller+BA%22">Mueller BA</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Camchong+J%22">Camchong J</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Houri+A%22">Houri A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kurma+S%22">Kurma S</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lim+KO%22">Lim KO</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cullen%2C+Kathryn+R%22">Cullen, Kathryn R</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Klimes-Dougan%2C+Bonnie%22">Klimes-Dougan, Bonnie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Muetzel%2C+Ryan%22">Muetzel, Ryan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mueller%2C+Bryon+A%22">Mueller, Bryon A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Camchong%2C+Jazmin%22">Camchong, Jazmin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Houri%2C+Alaa%22">Houri, Alaa</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kurma%2C+Sanjiv%22">Kurma, Sanjiv</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lim%2C+Kelvin+O%22">Lim, Kelvin O</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry%22">Journal of the American Academy of Child & Adolescent Psychiatry</searchLink>. Feb2010, Vol. 49 Issue 2, p173-183e1. 1p.
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: <bold>Objective: </bold>Major depressive disorder (MDD) occurs frequently in adolescents, but the neurobiology of depression in youth is poorly understood. Structural neuroimaging studies in both adult and pediatric populations have implicated frontolimbic neural networks in the pathophysiology of MDD. Diffusion tensor imaging (DTI), which measures white matter (WM) microstructure, is a promising tool for examining neural connections and how they may be abnormal in MDD.<bold>Method: </bold>We used two separate approaches to analyze DTI data in adolescents with MDD (n = 14) compared with healthy volunteers (n = 14).<bold>Results: </bold>The first, hypothesis-driven approach was to use probabilistic tractography to delineate tracts arising from the subgenual anterior cingulate cortex (ACC). Adolescents with MDD demonstrated lower fractional anisotropy (FA) in the WM tract connecting subgenual ACC to amygdala in the right hemisphere. The second, exploratory approach was to conduct a voxelwise comparison of FA. This analysis revealed 10 clusters where adolescents with MDD had significantly lower (uncorrected) FA than the healthy group within WM tracts including right and left uncinate and supragenual cingulum.<bold>Conclusions: </bold>These preliminary data support the hypothesis that altered WM microstructure in frontolimbic neural pathways may contribute to the pathophysiology of MDD in adolescents. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Journal of the American Academy of Child & Adolescent Psychiatry is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1097/00004583-201002000-00011
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              Text: Feb2010
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