Autologous chondrocyte implantation versus debridement for treatment of full-thickness chondral defects of the knee: an observational cohort study with 3-year follow-up.
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| Title: | Autologous chondrocyte implantation versus debridement for treatment of full-thickness chondral defects of the knee: an observational cohort study with 3-year follow-up. |
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| Authors: | Fu FH (AUTHOR), Zurakowski D (AUTHOR), Browne JE (AUTHOR), Mandelbaum B (AUTHOR), Erggelet C (AUTHOR), Moseley JB Jr. (AUTHOR), Anderson AF (AUTHOR), Micheli LJ (AUTHOR) |
| Source: | American Journal of Sports Medicine. Nov2005, Vol. 33 Issue 11, p1658-1666. 9p. |
| Abstract: | Background: Studies that compare the effectiveness of different cartilage repair treatments are needed to update treatment algorithms.Hypothesis: Autologous chondrocyte implantation provides greater improvement in overall condition score than does debridement at a minimum of 3 years' follow-up.Study Design: Cohort study; Level of evidence, 3.Methods: Cohorts for debridement and autologous chondrocyte implantation each included 58 Cartilage Repair Registry patients who met study criteria. A retrospective analysis was performed on prospectively collected baseline and follow-up data.Results: Patients in the autologous chondrocyte implantation and debridement groups had similar demographics and chondral lesions at baseline. However, more autologous chondrocyte implantation patients failed a previous debridement or marrow stimulation procedure than did debridement patients. Follow-up outcome assessments were completed by 54 autologous chondrocyte implantation patients and 42 debridement patients. Eighty-one percent of the autologous chondrocyte implantation patients and 60% of the debridement patients reported median improvements of 5 points and 2 points, respectively, in the overall condition score. Autologous chondrocyte implantation patients also reported greater improvements in the median pain and swelling scores than did debridement patients. The treatment failure rate was the same for both autologous chondrocyte implantation and debridement patients. Eighteen autologous chondrocyte implantation patients and 1 debridement patient had at least 1 subsequent operation.Conclusion: Although patients treated with debridement for symptomatic, large, focal, chondral defects of the distal femur had some functional improvement at follow-up, patients who received autologous chondrocyte implantations obtained higher levels of knee function and had greater relief from pain and swelling at 3 years. [ABSTRACT FROM AUTHOR] |
| Copyright of American Journal of Sports Medicine is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Education Research Complete |
| FullText | Text: Availability: 0 |
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| Header | DbId: ehh DbLabel: Education Research Complete An: 106381322 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Autologous chondrocyte implantation versus debridement for treatment of full-thickness chondral defects of the knee: an observational cohort study with 3-year follow-up. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Fu+FH%22">Fu FH</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zurakowski+D%22">Zurakowski D</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Browne+JE%22">Browne JE</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mandelbaum+B%22">Mandelbaum B</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Erggelet+C%22">Erggelet C</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Moseley+JB+Jr%2E%22">Moseley JB Jr.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Anderson+AF%22">Anderson AF</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Micheli+LJ%22">Micheli LJ</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22American+Journal+of+Sports+Medicine%22">American Journal of Sports Medicine</searchLink>. Nov2005, Vol. 33 Issue 11, p1658-1666. 9p. – Name: Abstract Label: Abstract Group: Ab Data: Background: Studies that compare the effectiveness of different cartilage repair treatments are needed to update treatment algorithms.Hypothesis: Autologous chondrocyte implantation provides greater improvement in overall condition score than does debridement at a minimum of 3 years' follow-up.Study Design: Cohort study; Level of evidence, 3.Methods: Cohorts for debridement and autologous chondrocyte implantation each included 58 Cartilage Repair Registry patients who met study criteria. A retrospective analysis was performed on prospectively collected baseline and follow-up data.Results: Patients in the autologous chondrocyte implantation and debridement groups had similar demographics and chondral lesions at baseline. However, more autologous chondrocyte implantation patients failed a previous debridement or marrow stimulation procedure than did debridement patients. Follow-up outcome assessments were completed by 54 autologous chondrocyte implantation patients and 42 debridement patients. Eighty-one percent of the autologous chondrocyte implantation patients and 60% of the debridement patients reported median improvements of 5 points and 2 points, respectively, in the overall condition score. Autologous chondrocyte implantation patients also reported greater improvements in the median pain and swelling scores than did debridement patients. The treatment failure rate was the same for both autologous chondrocyte implantation and debridement patients. Eighteen autologous chondrocyte implantation patients and 1 debridement patient had at least 1 subsequent operation.Conclusion: Although patients treated with debridement for symptomatic, large, focal, chondral defects of the distal femur had some functional improvement at follow-up, patients who received autologous chondrocyte implantations obtained higher levels of knee function and had greater relief from pain and swelling at 3 years. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of American Journal of Sports Medicine is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 1658 Titles: – TitleFull: Autologous chondrocyte implantation versus debridement for treatment of full-thickness chondral defects of the knee: an observational cohort study with 3-year follow-up. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Fu FH – PersonEntity: Name: NameFull: Zurakowski D – PersonEntity: Name: NameFull: Browne JE – PersonEntity: Name: NameFull: Mandelbaum B – PersonEntity: Name: NameFull: Erggelet C – PersonEntity: Name: NameFull: Moseley JB Jr. – PersonEntity: Name: NameFull: Anderson AF – PersonEntity: Name: NameFull: Micheli LJ IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2005 Type: published Y: 2005 Identifiers: – Type: issn-print Value: 03635465 Numbering: – Type: volume Value: 33 – Type: issue Value: 11 Titles: – TitleFull: American Journal of Sports Medicine Type: main |
| ResultId | 1 |
