The use of a single osteochondral autograft plug in the treatment of a large osteochondral lesion in the femoral condyle: an experimental study in sheep.
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| Title: | The use of a single osteochondral autograft plug in the treatment of a large osteochondral lesion in the femoral condyle: an experimental study in sheep. |
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| Authors: | Burks RT (AUTHOR), Greis PE (AUTHOR), Arnoczky SP (AUTHOR), Scher C (AUTHOR) |
| Source: | American Journal of Sports Medicine. Feb2006, Vol. 34 Issue 2, p247-255. 9p. |
| Abstract: | Background: The use of osteochondral autograft plugs can be restricted because of limited amount of donor material.Hypothesis: A small osteochondral autograft plug placed in the center of a large defect in a sheep femoral condyle will yield results superior to either an untreated or a bone-grafted defect.Study Design: Controlled laboratory study.Methods: Twelve adult sheep underwent bilateral hindlimb surgery. On 1 limb, a 6-mm circular osteochondral autograft plug was placed in the center of a 10-mm circular defect in the medial femoral condyle. The gap between the plug and the condyle was filled with bone graft. On the contralateral side, the defect was either left untreated or filled with bone graft (control specimens). Animals were studied at 6 and 12 months under gross examination, high-resolution radiography, and histologic evaluation.Results: At 6 months, 4 of 6 plugs healed and showed good maintenance of the joint surface and cartilage viability in the plugs. One plug fractured and resorbed, and 1 plug settled but healed. At 1 year, all 5 plugs healed, 1 having settled slightly (1 animal died earlier). The plug specimens showed better maintenance of the condyle contour at both times, and the central plug had hyaline-appearing cartilage. The control specimens were more irregular, had a fibrocartilage fill, and appeared flatter, although no gross cavitation or collapse was indicated. Composite cartilage scores on histologic evaluation were significantly higher for the plug specimens after 6 months (P = .02) and 1 year (P = .036) compared with controls.Conclusion: At 6 months and 1 year, a 6-mm osteochondral plug placed in a 10-mm defect better preserved the articular surface and contour of the condyle compared to untreated or bone-grafted defects.Clinical Relevance: Osteochondral autograft plugs may be able to treat larger articular lesions without complete fill of the defect. [ABSTRACT FROM AUTHOR] |
| Copyright of American Journal of Sports Medicine is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Education Research Complete |
| FullText | Text: Availability: 0 |
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| Header | DbId: ehh DbLabel: Education Research Complete An: 106427328 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The use of a single osteochondral autograft plug in the treatment of a large osteochondral lesion in the femoral condyle: an experimental study in sheep. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Burks+RT%22">Burks RT</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Greis+PE%22">Greis PE</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Arnoczky+SP%22">Arnoczky SP</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Scher+C%22">Scher C</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22American+Journal+of+Sports+Medicine%22">American Journal of Sports Medicine</searchLink>. Feb2006, Vol. 34 Issue 2, p247-255. 9p. – Name: Abstract Label: Abstract Group: Ab Data: Background: The use of osteochondral autograft plugs can be restricted because of limited amount of donor material.Hypothesis: A small osteochondral autograft plug placed in the center of a large defect in a sheep femoral condyle will yield results superior to either an untreated or a bone-grafted defect.Study Design: Controlled laboratory study.Methods: Twelve adult sheep underwent bilateral hindlimb surgery. On 1 limb, a 6-mm circular osteochondral autograft plug was placed in the center of a 10-mm circular defect in the medial femoral condyle. The gap between the plug and the condyle was filled with bone graft. On the contralateral side, the defect was either left untreated or filled with bone graft (control specimens). Animals were studied at 6 and 12 months under gross examination, high-resolution radiography, and histologic evaluation.Results: At 6 months, 4 of 6 plugs healed and showed good maintenance of the joint surface and cartilage viability in the plugs. One plug fractured and resorbed, and 1 plug settled but healed. At 1 year, all 5 plugs healed, 1 having settled slightly (1 animal died earlier). The plug specimens showed better maintenance of the condyle contour at both times, and the central plug had hyaline-appearing cartilage. The control specimens were more irregular, had a fibrocartilage fill, and appeared flatter, although no gross cavitation or collapse was indicated. Composite cartilage scores on histologic evaluation were significantly higher for the plug specimens after 6 months (P = .02) and 1 year (P = .036) compared with controls.Conclusion: At 6 months and 1 year, a 6-mm osteochondral plug placed in a 10-mm defect better preserved the articular surface and contour of the condyle compared to untreated or bone-grafted defects.Clinical Relevance: Osteochondral autograft plugs may be able to treat larger articular lesions without complete fill of the defect. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of American Journal of Sports Medicine is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1177/0363546505279914 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 247 Titles: – TitleFull: The use of a single osteochondral autograft plug in the treatment of a large osteochondral lesion in the femoral condyle: an experimental study in sheep. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Burks RT – PersonEntity: Name: NameFull: Greis PE – PersonEntity: Name: NameFull: Arnoczky SP – PersonEntity: Name: NameFull: Scher C IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2006 Type: published Y: 2006 Identifiers: – Type: issn-print Value: 03635465 Numbering: – Type: volume Value: 34 – Type: issue Value: 2 Titles: – TitleFull: American Journal of Sports Medicine Type: main |
| ResultId | 1 |
