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Systematic Review and Meta-Analysis: Cognitive-Behavioral Therapy for Obsessive-Compulsive Disorder in Children and Adolescents.

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Title: Systematic Review and Meta-Analysis: Cognitive-Behavioral Therapy for Obsessive-Compulsive Disorder in Children and Adolescents.
Authors: Uhre, Camilla Funch1,2 (AUTHOR) Camilla.funch.staugaard@regionh.dk, Uhre, Valdemar Funch1,2,3 (AUTHOR), Lønfeldt, Nicole Nadine1 (AUTHOR), Pretzmann, Linea1 (AUTHOR), Vangkilde, Signe1,4 (AUTHOR), Plessen, Kerstin Jessica5 (AUTHOR), Gluud, Christian6,7 (AUTHOR), Jakobsen, Janus Christian6,8 (AUTHOR), Pagsberg, Anne Katrine1,2 (AUTHOR)
Source: Journal of the American Academy of Child & Adolescent Psychiatry. Jan2020, Vol. 59 Issue 1, p64-77. 14p.
Subject Terms: *Cognitive therapy, *Quality of life, Obsessive-compulsive disorder, Meta-analysis, Serotonin uptake inhibitors, Clinical trials, Systematic reviews, Psychological factors
Abstract: Objective: To assess benefits and harms of cognitive-behavioral therapy (CBT) versus no intervention or versus other interventions for pediatric obsessive-compulsive disorder (OCD).Method: We searched for randomized clinical trials of CBT for pediatric OCD. Primary outcomes were OCD severity, serious adverse events, and level of functioning. Secondary outcomes were quality of life and adverse events. Remission from OCD was included as an exploratory outcome. We assessed risk of bias and evaluated the certainty of the evidence with the Grading of Recommendations Assessment, Development and Evaluation (GRADE).Results: Nine trials (N = 645) were included comparing CBT with no intervention and 3 trials (N = 146) comparing CBT with selective serotonin reuptake inhibitors (SSRIs). Compared with no intervention, CBT decreased OCD severity (mean difference [MD] = -8.51, 95% CI = -10.84 to -6.18, p < .00001, low certainty), improved level of functioning (patient-rated: standardized MD [SMD] = -0.90, 95% CI = -1.19 to -0.62, p < .00001, very low certainty; parent-rated: SMD = -0.68, 95% CI = -1.12 to -0.23, p = .003, very low certainty), had similar proportions of participants with adverse events (risk ratio = 1.06, 95% CI = 0.93-1.22, p = .39, GRADE: low certainty), and was associated with reduced risk of still having OCD (risk ratio = 0.50, 95% CI = 0.37-0.67, p < .00001, very low certainty). We had insufficient data to assess the effect of CBT versus no intervention on serious adverse events and quality of life. Compared with SSRIs, CBT led to similar decreases in OCD severity (MD = -0.75, 95% CI = -3.79 to 2.29, p = .63, GRADE: very low certainty), and was associated with similar risk of still having OCD (risk ratio = 0.85, 95% CI = 0.66-1.09, p = .20, very low certainty). We had insufficient data to assess the effect of CBT versus SSRIs on serious adverse events, level of functioning, quality of life, and adverse events.Conclusion: CBT may be more effective than no intervention and comparable to SSRIs for pediatric OCD, but we are very uncertain about the effect estimates. [ABSTRACT FROM AUTHOR]
Copyright of Journal of the American Academy of Child & Adolescent Psychiatry is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Education Research Complete
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  Data: Systematic Review and Meta-Analysis: Cognitive-Behavioral Therapy for Obsessive-Compulsive Disorder in Children and Adolescents.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Uhre%2C+Camilla+Funch%22&quot;&gt;Uhre, Camilla Funch&lt;/searchLink&gt;&lt;relatesTo&gt;1,2&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; Camilla.funch.staugaard@regionh.dk&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Uhre%2C+Valdemar+Funch%22&quot;&gt;Uhre, Valdemar Funch&lt;/searchLink&gt;&lt;relatesTo&gt;1,2,3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22L&#248;nfeldt%2C+Nicole+Nadine%22&quot;&gt;L&#248;nfeldt, Nicole Nadine&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Pretzmann%2C+Linea%22&quot;&gt;Pretzmann, Linea&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Vangkilde%2C+Signe%22&quot;&gt;Vangkilde, Signe&lt;/searchLink&gt;&lt;relatesTo&gt;1,4&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Plessen%2C+Kerstin+Jessica%22&quot;&gt;Plessen, Kerstin Jessica&lt;/searchLink&gt;&lt;relatesTo&gt;5&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gluud%2C+Christian%22&quot;&gt;Gluud, Christian&lt;/searchLink&gt;&lt;relatesTo&gt;6,7&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Jakobsen%2C+Janus+Christian%22&quot;&gt;Jakobsen, Janus Christian&lt;/searchLink&gt;&lt;relatesTo&gt;6,8&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Pagsberg%2C+Anne+Katrine%22&quot;&gt;Pagsberg, Anne Katrine&lt;/searchLink&gt;&lt;relatesTo&gt;1,2&lt;/relatesTo&gt; (AUTHOR)
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  Data: &lt;bold&gt;Objective: &lt;/bold&gt;To assess benefits and harms of cognitive-behavioral therapy (CBT) versus no intervention or versus other interventions for pediatric obsessive-compulsive disorder (OCD).&lt;bold&gt;Method: &lt;/bold&gt;We searched for randomized clinical trials of CBT for pediatric OCD. Primary outcomes were OCD severity, serious adverse events, and level of functioning. Secondary outcomes were quality of life and adverse events. Remission from OCD was included as an exploratory outcome. We assessed risk of bias and evaluated the certainty of the evidence with the Grading of Recommendations Assessment, Development and Evaluation (GRADE).&lt;bold&gt;Results: &lt;/bold&gt;Nine trials (N&#160;= 645) were included comparing CBT with no intervention and 3 trials (N&#160;= 146) comparing CBT with selective serotonin reuptake inhibitors (SSRIs). Compared with no intervention, CBT decreased OCD severity (mean difference [MD]&#160;=&#160;-8.51, 95% CI&#160;=&#160;-10.84 to&#160;-6.18, p&#160;&lt; .00001, low certainty), improved level of functioning (patient-rated: standardized MD [SMD]&#160;=&#160;-0.90, 95% CI&#160;=&#160;-1.19 to&#160;-0.62, p&#160;&lt; .00001, very low certainty; parent-rated: SMD&#160;=&#160;-0.68, 95% CI&#160;=&#160;-1.12 to&#160;-0.23, p&#160;= .003, very low certainty), had similar proportions of participants with adverse events (risk ratio&#160;= 1.06, 95% CI&#160;= 0.93-1.22, p&#160;= .39, GRADE: low certainty), and was associated with reduced risk of still having OCD (risk ratio&#160;= 0.50, 95% CI&#160;= 0.37-0.67, p&#160;&lt; .00001, very low certainty). We had insufficient data to assess the effect of CBT versus no intervention on serious adverse events and quality of life. Compared with SSRIs, CBT led to similar decreases in OCD severity (MD&#160;=&#160;-0.75, 95% CI&#160;=&#160;-3.79 to 2.29, p&#160;= .63, GRADE: very low certainty), and was associated with similar risk of still having OCD (risk ratio&#160;= 0.85, 95% CI&#160;= 0.66-1.09, p&#160;= .20, very low certainty). We had insufficient data to assess the effect of CBT versus SSRIs on serious adverse events, level of functioning, quality of life, and adverse events.&lt;bold&gt;Conclusion: &lt;/bold&gt;CBT may be more effective than no intervention and comparable to SSRIs for pediatric OCD, but we are very uncertain about the effect estimates. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Journal of the American Academy of Child &amp; Adolescent Psychiatry is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.jaac.2019.08.480
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