View in EDS PDF Full Text

HEMOSTATIC ABNORMALITIES IN COVID-19: UNDERLYING MECHANISMS AND CLUES TO TREATMENT: Do we Really See a "Storm" Never Seen Before?

Saved in:
Bibliographic Details
Title: HEMOSTATIC ABNORMALITIES IN COVID-19: UNDERLYING MECHANISMS AND CLUES TO TREATMENT: Do we Really See a "Storm" Never Seen Before?
Authors: Antovic, Jovan P.1,2 Jovan.Antovic@sll.se
Source: Online Learning. 2020, Vol. 24 Issue 3, p1-6. 6p.
Subject Terms: *University hospitals, COVID-19, Passive euthanasia, Human abnormalities, Anticoagulants, Influenza
Abstract: Despite relatively short time since Covid-19 infection has appeared in the world, enormous amount of literature data (more than 20 000 articles currently (mid-June)) is available on PubMed. Those data, together with our own experience at Karolinska University Hospital point towards hemostatic abnormalities in significant number of severe patients. Majority of those patients experience persistent hypercoagulation with massively increased Ddimer and fibrinogen. As a consequence, clinical thrombotic events, including venous thromboembolism (VTE) are common in Covid-19 patients and it seems that increased anticoagulant prophylaxis may be beneficial for severe (ICU/mechanical ventilation) patients. The lungs are most severely injured by the virus and that the potential underlying mechanism is a crosstalk between inflammation/complement and hemostasis. It is important to emphasize that the importance of hemostatic abnormalities in Covid-19 patients should not be overestimated since thromboembolic phenomena are, to a similar extent, present in other influenza and severely ill patients. [ABSTRACT FROM AUTHOR]
Copyright of Online Learning is the property of Online Learning Consortium and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Education Research Complete
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: ehh
DbLabel: Education Research Complete
An: 145917385
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: HEMOSTATIC ABNORMALITIES IN COVID-19: UNDERLYING MECHANISMS AND CLUES TO TREATMENT: Do we Really See a "Storm" Never Seen Before?
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Antovic%2C+Jovan+P%2E%22">Antovic, Jovan P.</searchLink><relatesTo>1,2</relatesTo><i> Jovan.Antovic@sll.se</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Online+Learning%22">Online Learning</searchLink>. 2020, Vol. 24 Issue 3, p1-6. 6p.
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: *<searchLink fieldCode="DE" term="%22University+hospitals%22">University hospitals</searchLink><br /><searchLink fieldCode="DE" term="%22COVID-19%22">COVID-19</searchLink><br /><searchLink fieldCode="DE" term="%22Passive+euthanasia%22">Passive euthanasia</searchLink><br /><searchLink fieldCode="DE" term="%22Human+abnormalities%22">Human abnormalities</searchLink><br /><searchLink fieldCode="DE" term="%22Anticoagulants%22">Anticoagulants</searchLink><br /><searchLink fieldCode="DE" term="%22Influenza%22">Influenza</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Despite relatively short time since Covid-19 infection has appeared in the world, enormous amount of literature data (more than 20 000 articles currently (mid-June)) is available on PubMed. Those data, together with our own experience at Karolinska University Hospital point towards hemostatic abnormalities in significant number of severe patients. Majority of those patients experience persistent hypercoagulation with massively increased Ddimer and fibrinogen. As a consequence, clinical thrombotic events, including venous thromboembolism (VTE) are common in Covid-19 patients and it seems that increased anticoagulant prophylaxis may be beneficial for severe (ICU/mechanical ventilation) patients. The lungs are most severely injured by the virus and that the potential underlying mechanism is a crosstalk between inflammation/complement and hemostasis. It is important to emphasize that the importance of hemostatic abnormalities in Covid-19 patients should not be overestimated since thromboembolic phenomena are, to a similar extent, present in other influenza and severely ill patients. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Online Learning is the property of Online Learning Consortium and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=ehh&AN=145917385
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.22190/FUMB200620002A
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 6
        StartPage: 1
    Subjects:
      – SubjectFull: University hospitals
        Type: general
      – SubjectFull: COVID-19
        Type: general
      – SubjectFull: Passive euthanasia
        Type: general
      – SubjectFull: Human abnormalities
        Type: general
      – SubjectFull: Anticoagulants
        Type: general
      – SubjectFull: Influenza
        Type: general
    Titles:
      – TitleFull: HEMOSTATIC ABNORMALITIES IN COVID-19: UNDERLYING MECHANISMS AND CLUES TO TREATMENT: Do we Really See a "Storm" Never Seen Before?
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Antovic, Jovan P.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 07
              Text: 2020
              Type: published
              Y: 2020
          Identifiers:
            – Type: issn-print
              Value: 24725749
          Numbering:
            – Type: volume
              Value: 24
            – Type: issue
              Value: 3
          Titles:
            – TitleFull: Online Learning
              Type: main
ResultId 1