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Functional Connectivity of Attention-Related Networks in Drug-Naïve Children With ADHD.

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Title: Functional Connectivity of Attention-Related Networks in Drug-Naïve Children With ADHD.
Authors: Lin, Haixi1, Lin, Qingxia1, Li, Hailong2, Wang, Meihao1, Chen, Hong1, Liang, Yan1, Bu, Xuan2, Wang, Weiqian1, Yi, Yanhong1, Zhao, Yongzhong1, Zhang, Xiaoyan1, Xie, Yupeng1, Du, Songmei1, Yang, Chuang1 dryangchuang@163.com, Huang, Xiaoqi2
Source: Journal of Attention Disorders. Feb2021, Vol. 25 Issue 3, p377-388. 12p.
Subject Terms: *Attention-deficit hyperactivity disorder, *Statistical correlation, *Brain, *Research, *Research methodology, *Evaluation research, *Comparative studies, Functional magnetic resonance imaging, Functional connectivity, Somatosensory disorders, Neural pathways, Magnetic resonance imaging, Brain mapping, Medical cooperation, Drugs
Abstract: Objective: This study aimed to explore alterations of seed-based functional connectivity (FC) in dorsal attention network (DAN), ventral attention network (VAN), and default mode network (DMN) in ADHD children. Method: A voxel-based comparison of FC maps between 46 drug-naïve children with ADHD and 31 healthy controls (HCs) and correlation analysis between connectivity features and behavior were performed. Results: Compared with the HCs, children with ADHD were characterized by hyperconnectivity between DAN and regions of DMN and by hyperconnectivity between DMN and a set of regions involved in somatosensory, visual, and auditory cortices. No significant group different FC was found between VAN and the whole brain. Higher FC between DMN and somatosensory, visual, and auditory cortex was associated with better performance in attention and executive function. Conclusion: The dysregulation of networks in children with ADHD not only involves the DAN and DMN but also the somatosensory, motor, visual, and auditory networks. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Attention Disorders is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Education Research Complete
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Header DbId: ehh
DbLabel: Education Research Complete
An: 147842697
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Functional Connectivity of Attention-Related Networks in Drug-Naïve Children With ADHD.
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  Data: <searchLink fieldCode="AR" term="%22Lin%2C+Haixi%22">Lin, Haixi</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Lin%2C+Qingxia%22">Lin, Qingxia</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Li%2C+Hailong%22">Li, Hailong</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Wang%2C+Meihao%22">Wang, Meihao</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Chen%2C+Hong%22">Chen, Hong</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Liang%2C+Yan%22">Liang, Yan</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Bu%2C+Xuan%22">Bu, Xuan</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Wang%2C+Weiqian%22">Wang, Weiqian</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Yi%2C+Yanhong%22">Yi, Yanhong</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Zhao%2C+Yongzhong%22">Zhao, Yongzhong</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Xiaoyan%22">Zhang, Xiaoyan</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Xie%2C+Yupeng%22">Xie, Yupeng</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Du%2C+Songmei%22">Du, Songmei</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Yang%2C+Chuang%22">Yang, Chuang</searchLink><relatesTo>1</relatesTo><i> dryangchuang@163.com</i><br /><searchLink fieldCode="AR" term="%22Huang%2C+Xiaoqi%22">Huang, Xiaoqi</searchLink><relatesTo>2</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Attention+Disorders%22">Journal of Attention Disorders</searchLink>. Feb2021, Vol. 25 Issue 3, p377-388. 12p.
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  Data: *<searchLink fieldCode="DE" term="%22Attention-deficit+hyperactivity+disorder%22">Attention-deficit hyperactivity disorder</searchLink><br />*<searchLink fieldCode="DE" term="%22Statistical+correlation%22">Statistical correlation</searchLink><br />*<searchLink fieldCode="DE" term="%22Brain%22">Brain</searchLink><br />*<searchLink fieldCode="DE" term="%22Research%22">Research</searchLink><br />*<searchLink fieldCode="DE" term="%22Research+methodology%22">Research methodology</searchLink><br />*<searchLink fieldCode="DE" term="%22Evaluation+research%22">Evaluation research</searchLink><br />*<searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+magnetic+resonance+imaging%22">Functional magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+connectivity%22">Functional connectivity</searchLink><br /><searchLink fieldCode="DE" term="%22Somatosensory+disorders%22">Somatosensory disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+pathways%22">Neural pathways</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+mapping%22">Brain mapping</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+cooperation%22">Medical cooperation</searchLink><br /><searchLink fieldCode="DE" term="%22Drugs%22">Drugs</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: This study aimed to explore alterations of seed-based functional connectivity (FC) in dorsal attention network (DAN), ventral attention network (VAN), and default mode network (DMN) in ADHD children. Method: A voxel-based comparison of FC maps between 46 drug-naïve children with ADHD and 31 healthy controls (HCs) and correlation analysis between connectivity features and behavior were performed. Results: Compared with the HCs, children with ADHD were characterized by hyperconnectivity between DAN and regions of DMN and by hyperconnectivity between DMN and a set of regions involved in somatosensory, visual, and auditory cortices. No significant group different FC was found between VAN and the whole brain. Higher FC between DMN and somatosensory, visual, and auditory cortex was associated with better performance in attention and executive function. Conclusion: The dysregulation of networks in children with ADHD not only involves the DAN and DMN but also the somatosensory, motor, visual, and auditory networks. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Attention Disorders is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1177/1087054718802017
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      – Code: eng
        Text: English
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        PageCount: 12
        StartPage: 377
    Subjects:
      – SubjectFull: Attention-deficit hyperactivity disorder
        Type: general
      – SubjectFull: Statistical correlation
        Type: general
      – SubjectFull: Brain
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      – SubjectFull: Research
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      – SubjectFull: Research methodology
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      – SubjectFull: Evaluation research
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      – SubjectFull: Comparative studies
        Type: general
      – SubjectFull: Functional magnetic resonance imaging
        Type: general
      – SubjectFull: Functional connectivity
        Type: general
      – SubjectFull: Somatosensory disorders
        Type: general
      – SubjectFull: Neural pathways
        Type: general
      – SubjectFull: Magnetic resonance imaging
        Type: general
      – SubjectFull: Brain mapping
        Type: general
      – SubjectFull: Medical cooperation
        Type: general
      – SubjectFull: Drugs
        Type: general
    Titles:
      – TitleFull: Functional Connectivity of Attention-Related Networks in Drug-Naïve Children With ADHD.
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              M: 02
              Text: Feb2021
              Type: published
              Y: 2021
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            – TitleFull: Journal of Attention Disorders
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