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Drugs age-of-onset as a signal of later post-traumatic stress disorder: Bayesian analysis of a census protocol.

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Title: Drugs age-of-onset as a signal of later post-traumatic stress disorder: Bayesian analysis of a census protocol.
Authors: Santos, Lene L.1 (AUTHOR), Netto, Liana R.1 (AUTHOR), Cavalcanti-Ribeiro, Patrícia1 (AUTHOR), Pereira, Juliana L.1,2 (AUTHOR), Souza-Marques, Breno1 (AUTHOR), Argolo, Felipe3,4 (AUTHOR), Lira, Sidnei B.1 (AUTHOR), Fontes, Gabriel5 (AUTHOR), Moreira, Esdras C.6 (AUTHOR), Anthony, James C.7 (AUTHOR), Koenen, Karestan C.8 (AUTHOR), Quarantini, Lucas C.1,6 (AUTHOR) lcq@ufba.br, Trauma, Anxiety Disorders Study Group-TADSG (CORPORATE AUTHOR)
Source: Addictive Behaviors. Feb2022, Vol. 125, pN.PAG-N.PAG. 1p.
Subject Terms: *Bayesian analysis, *Adolescent development, *Research, *Census, *Research methodology, *Evaluation research, *Comparative studies, Post-traumatic stress disorder, Substance-induced disorders, Drug utilization, Drugs, Alcohol drinking, Questionnaires, Probability theory
Abstract: Individuals with PTSD have an increased risk of drug use disorders. Conversely, we aim to evaluate how early onset of alcohol, tobacco and psychoactive drugs use are associated with PTSD later in life. 2,193 brazilian young adults completed modularized assessments: The Trauma History Questionnaire, Post-Traumatic Stress Disorder Checklist-Civilian Version (PCL-C, transformed to PCL-5 through a crosswalk procedure), the Barratt Impulsivity Scale; and a survey on drug use with self-report questions about first use, current use, frequency, quantity, and interpersonal consequences. Bayesian inference and multivariate regression models were used to examine the effects on the risk of PTSD, considering different assumptions of information flow. Raw and unbiased (multivariate) estimates consistently revealed that earlier age of onset of alcohol and tobacco use increased risk for PTSD (Odds-ratios between 2.39 and 3.19 (Alcohol) and 1.82 to 2.05 (Tobacco). Among those who had PTSD (310), 10.3% (32) were very precocious at the onset age (12 to 18 years) of alcohol consumption (No-PTSD: 89 out 1883, 4.7%). Data supports a model in which age of onset effects are partially mediated by the number of trauma exposures. Early intoxication might suggest vulnerability for qualifying trauma events, or it may increase chances of exposure. Also, PTSD may be more likely to occur among trauma-exposed individuals with early intoxicating experiences due to alcohol or drug self-administration. The last possibility resonates with the idea that early intoxication might disrupt adolescent brain development, with a subsequent reduction in resilience when qualifying trauma events occur. [ABSTRACT FROM AUTHOR]
Copyright of Addictive Behaviors is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Education Research Complete
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DbLabel: Education Research Complete
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PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Drugs age-of-onset as a signal of later post-traumatic stress disorder: Bayesian analysis of a census protocol.
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  Data: <searchLink fieldCode="AR" term="%22Santos%2C+Lene+L%2E%22">Santos, Lene L.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Netto%2C+Liana+R%2E%22">Netto, Liana R.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cavalcanti-Ribeiro%2C+Patrícia%22">Cavalcanti-Ribeiro, Patrícia</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pereira%2C+Juliana+L%2E%22">Pereira, Juliana L.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Souza-Marques%2C+Breno%22">Souza-Marques, Breno</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Argolo%2C+Felipe%22">Argolo, Felipe</searchLink><relatesTo>3,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lira%2C+Sidnei+B%2E%22">Lira, Sidnei B.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fontes%2C+Gabriel%22">Fontes, Gabriel</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Moreira%2C+Esdras+C%2E%22">Moreira, Esdras C.</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Anthony%2C+James+C%2E%22">Anthony, James C.</searchLink><relatesTo>7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Koenen%2C+Karestan+C%2E%22">Koenen, Karestan C.</searchLink><relatesTo>8</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Quarantini%2C+Lucas+C%2E%22">Quarantini, Lucas C.</searchLink><relatesTo>1,6</relatesTo> (AUTHOR)<i> lcq@ufba.br</i><br /><searchLink fieldCode="AR" term="%22Trauma%2C+Anxiety+Disorders+Study+Group-TADSG%22">Trauma, Anxiety Disorders Study Group-TADSG</searchLink> (CORPORATE AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Addictive+Behaviors%22">Addictive Behaviors</searchLink>. Feb2022, Vol. 125, pN.PAG-N.PAG. 1p.
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  Data: *<searchLink fieldCode="DE" term="%22Bayesian+analysis%22">Bayesian analysis</searchLink><br />*<searchLink fieldCode="DE" term="%22Adolescent+development%22">Adolescent development</searchLink><br />*<searchLink fieldCode="DE" term="%22Research%22">Research</searchLink><br />*<searchLink fieldCode="DE" term="%22Census%22">Census</searchLink><br />*<searchLink fieldCode="DE" term="%22Research+methodology%22">Research methodology</searchLink><br />*<searchLink fieldCode="DE" term="%22Evaluation+research%22">Evaluation research</searchLink><br />*<searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Post-traumatic+stress+disorder%22">Post-traumatic stress disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Substance-induced+disorders%22">Substance-induced disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+utilization%22">Drug utilization</searchLink><br /><searchLink fieldCode="DE" term="%22Drugs%22">Drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Alcohol+drinking%22">Alcohol drinking</searchLink><br /><searchLink fieldCode="DE" term="%22Questionnaires%22">Questionnaires</searchLink><br /><searchLink fieldCode="DE" term="%22Probability+theory%22">Probability theory</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Individuals with PTSD have an increased risk of drug use disorders. Conversely, we aim to evaluate how early onset of alcohol, tobacco and psychoactive drugs use are associated with PTSD later in life. 2,193 brazilian young adults completed modularized assessments: The Trauma History Questionnaire, Post-Traumatic Stress Disorder Checklist-Civilian Version (PCL-C, transformed to PCL-5 through a crosswalk procedure), the Barratt Impulsivity Scale; and a survey on drug use with self-report questions about first use, current use, frequency, quantity, and interpersonal consequences. Bayesian inference and multivariate regression models were used to examine the effects on the risk of PTSD, considering different assumptions of information flow. Raw and unbiased (multivariate) estimates consistently revealed that earlier age of onset of alcohol and tobacco use increased risk for PTSD (Odds-ratios between 2.39 and 3.19 (Alcohol) and 1.82 to 2.05 (Tobacco). Among those who had PTSD (310), 10.3% (32) were very precocious at the onset age (12 to 18 years) of alcohol consumption (No-PTSD: 89 out 1883, 4.7%). Data supports a model in which age of onset effects are partially mediated by the number of trauma exposures. Early intoxication might suggest vulnerability for qualifying trauma events, or it may increase chances of exposure. Also, PTSD may be more likely to occur among trauma-exposed individuals with early intoxicating experiences due to alcohol or drug self-administration. The last possibility resonates with the idea that early intoxication might disrupt adolescent brain development, with a subsequent reduction in resilience when qualifying trauma events occur. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Addictive Behaviors is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=ehh&AN=153751478
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.addbeh.2021.107131
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 1
        StartPage: N.PAG
    Subjects:
      – SubjectFull: Bayesian analysis
        Type: general
      – SubjectFull: Adolescent development
        Type: general
      – SubjectFull: Research
        Type: general
      – SubjectFull: Census
        Type: general
      – SubjectFull: Research methodology
        Type: general
      – SubjectFull: Evaluation research
        Type: general
      – SubjectFull: Comparative studies
        Type: general
      – SubjectFull: Post-traumatic stress disorder
        Type: general
      – SubjectFull: Substance-induced disorders
        Type: general
      – SubjectFull: Drug utilization
        Type: general
      – SubjectFull: Drugs
        Type: general
      – SubjectFull: Alcohol drinking
        Type: general
      – SubjectFull: Questionnaires
        Type: general
      – SubjectFull: Probability theory
        Type: general
    Titles:
      – TitleFull: Drugs age-of-onset as a signal of later post-traumatic stress disorder: Bayesian analysis of a census protocol.
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            – D: 01
              M: 02
              Text: Feb2022
              Type: published
              Y: 2022
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