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Cancer patient knowledge about and behavioral intentions after germline genome sequencing.

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Title: Cancer patient knowledge about and behavioral intentions after germline genome sequencing.
Authors: Napier, Christine E.1 (AUTHOR), Davies, Grace2 (AUTHOR), Butow, Phyllis N.2,3 (AUTHOR), Schlub, Timothy E.4 (AUTHOR), Best, Megan C.2,5 (AUTHOR), Bartley, Nicci2 (AUTHOR), Juraskova, Ilona2,3 (AUTHOR), Meiser, Bettina6 (AUTHOR), Tucker, Katherine M.6,7 (AUTHOR), Biesecker, Barbara B.8 (AUTHOR), Thomas, David M.1,9 (AUTHOR), Ballinger, Mandy L.1,9 (AUTHOR) m.ballinger@garvan.org.au, Members of the PiGeOn Project (CORPORATE AUTHOR)
Source: Patient Education & Counseling. Mar2022, Vol. 105 Issue 3, p707-718. 12p.
Subject Terms: *Research, *Research methodology, *Evaluation research, *Comparative studies, Nucleotide sequencing, Health behavior, Germ cells, Intention, Cancer patients, Cancer prognosis, Tumor treatment, Cross-sectional method, Health attitudes, Genomics, Tumors
Abstract: Objectives: Germline genome sequencing (GS) is becoming mainstream in cancer diagnosis and risk management. Identifying knowledge gaps and determinants of health behavior change intentions will enable effective targeting of educational and management strategies to translate genomic findings into improved cancer outcomes.Methods: Probands diagnosed with cancer of likely genetic origin that consented to but not yet undergone GS, and their biological relatives, completed a cross-sectional questionnaire assessing GS knowledge and hypothetical intention to change behaviors.Results: Probands (n = 348; 57% university educated) and relatives (n = 213; 38% university educated) had moderate GS knowledge levels, with greater knowledge associated with higher education. Both populations reported high behavioral change intentions, significantly associated with being female (p = 0.01) and greater perceived importance of GS (p < 0.001), and for probands: being from English-speaking households (p = 0.003), higher socio-economic status (p = 0.01) and greater self-efficacy (p = 0.02).Conclusions: Increasing GS knowledge will enable realistic participant expectations surrounding germline GS. Actual behavior change should be monitored to determine whether increased cancer risk knowledge results in altered cancer-related behavior and ultimately, cancer outcomes.Practice Implications: Educational resources should target specific populations to ensure informed decision-making and expectation management. Support tools facilitating and maintaining behavioral change may be needed to achieve improved cancer patient outcomes. [ABSTRACT FROM AUTHOR]
Copyright of Patient Education & Counseling is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Education Research Complete
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  Data: Cancer patient knowledge about and behavioral intentions after germline genome sequencing.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Napier%2C+Christine+E%2E%22&quot;&gt;Napier, Christine E.&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Davies%2C+Grace%22&quot;&gt;Davies, Grace&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Butow%2C+Phyllis+N%2E%22&quot;&gt;Butow, Phyllis N.&lt;/searchLink&gt;&lt;relatesTo&gt;2,3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Schlub%2C+Timothy+E%2E%22&quot;&gt;Schlub, Timothy E.&lt;/searchLink&gt;&lt;relatesTo&gt;4&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Best%2C+Megan+C%2E%22&quot;&gt;Best, Megan C.&lt;/searchLink&gt;&lt;relatesTo&gt;2,5&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Bartley%2C+Nicci%22&quot;&gt;Bartley, Nicci&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Juraskova%2C+Ilona%22&quot;&gt;Juraskova, Ilona&lt;/searchLink&gt;&lt;relatesTo&gt;2,3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Meiser%2C+Bettina%22&quot;&gt;Meiser, Bettina&lt;/searchLink&gt;&lt;relatesTo&gt;6&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Tucker%2C+Katherine+M%2E%22&quot;&gt;Tucker, Katherine M.&lt;/searchLink&gt;&lt;relatesTo&gt;6,7&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Biesecker%2C+Barbara+B%2E%22&quot;&gt;Biesecker, Barbara B.&lt;/searchLink&gt;&lt;relatesTo&gt;8&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Thomas%2C+David+M%2E%22&quot;&gt;Thomas, David M.&lt;/searchLink&gt;&lt;relatesTo&gt;1,9&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ballinger%2C+Mandy+L%2E%22&quot;&gt;Ballinger, Mandy L.&lt;/searchLink&gt;&lt;relatesTo&gt;1,9&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; m.ballinger@garvan.org.au&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Members+of+the+PiGeOn+Project%22&quot;&gt;Members of the PiGeOn Project&lt;/searchLink&gt; (CORPORATE AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Patient+Education+%26+Counseling%22&quot;&gt;Patient Education &amp; Counseling&lt;/searchLink&gt;. Mar2022, Vol. 105 Issue 3, p707-718. 12p.
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  Data: &lt;bold&gt;Objectives: &lt;/bold&gt;Germline genome sequencing (GS) is becoming mainstream in cancer diagnosis and risk management. Identifying knowledge gaps and determinants of health behavior change intentions will enable effective targeting of educational and management strategies to translate genomic findings into improved cancer outcomes.&lt;bold&gt;Methods: &lt;/bold&gt;Probands diagnosed with cancer of likely genetic origin that consented to but not yet undergone GS, and their biological relatives, completed a cross-sectional questionnaire assessing GS knowledge and hypothetical intention to change behaviors.&lt;bold&gt;Results: &lt;/bold&gt;Probands (n&#160;=&#160;348; 57% university educated) and relatives (n&#160;=&#160;213; 38% university educated) had moderate GS knowledge levels, with greater knowledge associated with higher education. Both populations reported high behavioral change intentions, significantly associated with being female (p&#160;=&#160;0.01) and greater perceived importance of GS (p&#160;&lt;&#160;0.001), and for probands: being from English-speaking households (p&#160;=&#160;0.003), higher socio-economic status (p&#160;=&#160;0.01) and greater self-efficacy (p&#160;=&#160;0.02).&lt;bold&gt;Conclusions: &lt;/bold&gt;Increasing GS knowledge will enable realistic participant expectations surrounding germline GS. Actual behavior change should be monitored to determine whether increased cancer risk knowledge results in altered cancer-related behavior and ultimately, cancer outcomes.&lt;bold&gt;Practice Implications: &lt;/bold&gt;Educational resources should target specific populations to ensure informed decision-making and expectation management. Support tools facilitating and maintaining behavioral change may be needed to achieve improved cancer patient outcomes. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Patient Education &amp; Counseling is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.pec.2021.07.004
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