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Psychological impact of comprehensive tumor genomic profiling results for advanced cancer patients.

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Title: Psychological impact of comprehensive tumor genomic profiling results for advanced cancer patients.
Authors: Butow, Phyllis N.1 (AUTHOR) phyllis.butow@sydney.edu.au, Best, Megan C.1 (AUTHOR), Davies, Grace1 (AUTHOR), Schlub, Timothy2 (AUTHOR), Napier, Christine E.3 (AUTHOR), Bartley, Nicci1 (AUTHOR), Ballinger, Mandy L.3,4 (AUTHOR), Juraskova, Ilona5 (AUTHOR), Meiser, Bettina6 (AUTHOR), Goldstein, David7 (AUTHOR), Biesecker, Barbara8 (AUTHOR), Thomas, David M.3,4 (AUTHOR), members of the PiGeOn Project (CORPORATE AUTHOR)
Source: Patient Education & Counseling. Jul2022, Vol. 105 Issue 7, p2206-2216. 11p.
Subject Terms: *Anxiety, Tumor treatment, Uncertainty, Genomics, Tumors
Geographic Terms: Australia
Abstract: Objective: Comprehensive tumor genomic profiling (CTGP) is increasingly used to personalize treatments, providing hope, but potentially disappointment, for patients. We explored psychological outcomes in patients with advanced, incurable cancer, after receiving CTGP results.Methods: Participants with advanced, incurable cancer (n = 560, mean age 56, 43% university educated) in this longitudinal substudy of the Molecular Screening and Therapeutics Program (MoST), completed questionnaires before and after receiving CGP results. MoST participants, recruited from Australian oncology clinics, undergo CTGP, and if there are actionable findings, are offered treatment in a related therapeutic trial if available.Results: Patients who received actionable results, (n = 356, 64%) had lower gene-related distress (MICRA) (p < 0.001) and Impact of Events scores (p = 0.039) than patients with non-actionable results. Those with actionable results offered ensured access to tailored treatment (n = 151) reported lower anxiety (p = 0.002) and depressive symptoms (p = 0.01) and greater hope (p = 0.002) than those not offered. Positive attitudes towards uncertainty and higher self-efficacy for coping with results were associated with lower psychological distress and uncertainty, and higher hope and satisfaction with the decision to have CTGP (ps=0.001-0.047). Those with higher knowledge reported greater anxiety (p = 0.034).Conclusion: Receiving a non-actionable CTGP result, or an actionable result without ensured access to treatment, may cause increased distress in advanced cancer patients. Coping style was also associated with distress.Practice Implications: Pre-testing assessment and counseling addressing attitudes toward uncertainty and self-efficacy, and post-CTGP result support for patients receiving a non-actionable result or who receive an actionable results without ensured access to treatment, may benefit patients. [ABSTRACT FROM AUTHOR]
Copyright of Patient Education & Counseling is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Education Research Complete
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  Data: Psychological impact of comprehensive tumor genomic profiling results for advanced cancer patients.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Butow%2C+Phyllis+N%2E%22&quot;&gt;Butow, Phyllis N.&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; phyllis.butow@sydney.edu.au&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Best%2C+Megan+C%2E%22&quot;&gt;Best, Megan C.&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Davies%2C+Grace%22&quot;&gt;Davies, Grace&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Schlub%2C+Timothy%22&quot;&gt;Schlub, Timothy&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Napier%2C+Christine+E%2E%22&quot;&gt;Napier, Christine E.&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Bartley%2C+Nicci%22&quot;&gt;Bartley, Nicci&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ballinger%2C+Mandy+L%2E%22&quot;&gt;Ballinger, Mandy L.&lt;/searchLink&gt;&lt;relatesTo&gt;3,4&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Juraskova%2C+Ilona%22&quot;&gt;Juraskova, Ilona&lt;/searchLink&gt;&lt;relatesTo&gt;5&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Meiser%2C+Bettina%22&quot;&gt;Meiser, Bettina&lt;/searchLink&gt;&lt;relatesTo&gt;6&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Goldstein%2C+David%22&quot;&gt;Goldstein, David&lt;/searchLink&gt;&lt;relatesTo&gt;7&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Biesecker%2C+Barbara%22&quot;&gt;Biesecker, Barbara&lt;/searchLink&gt;&lt;relatesTo&gt;8&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Thomas%2C+David+M%2E%22&quot;&gt;Thomas, David M.&lt;/searchLink&gt;&lt;relatesTo&gt;3,4&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22members+of+the+PiGeOn+Project%22&quot;&gt;members of the PiGeOn Project&lt;/searchLink&gt; (CORPORATE AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Patient+Education+%26+Counseling%22&quot;&gt;Patient Education &amp; Counseling&lt;/searchLink&gt;. Jul2022, Vol. 105 Issue 7, p2206-2216. 11p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Australia%22&quot;&gt;Australia&lt;/searchLink&gt;
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  Data: &lt;bold&gt;Objective: &lt;/bold&gt;Comprehensive tumor genomic profiling (CTGP) is increasingly used to personalize treatments, providing hope, but potentially disappointment, for patients. We explored psychological outcomes in patients with advanced, incurable cancer, after receiving CTGP results.&lt;bold&gt;Methods: &lt;/bold&gt;Participants with advanced, incurable cancer (n&#160;=&#160;560, mean age 56, 43% university educated) in this longitudinal substudy of the Molecular Screening and Therapeutics Program (MoST), completed questionnaires before and after receiving CGP results. MoST participants, recruited from Australian oncology clinics, undergo CTGP, and if there are actionable findings, are offered treatment in a related therapeutic trial if available.&lt;bold&gt;Results: &lt;/bold&gt;Patients who received actionable results, (n&#160;=&#160;356, 64%) had lower gene-related distress (MICRA) (p&#160;&lt;&#160;0.001) and Impact of Events scores (p&#160;=&#160;0.039) than patients with non-actionable results. Those with actionable results offered ensured access to tailored treatment (n&#160;=&#160;151) reported lower anxiety (p&#160;=&#160;0.002) and depressive symptoms (p&#160;=&#160;0.01) and greater hope (p&#160;=&#160;0.002) than those not offered. Positive attitudes towards uncertainty and higher self-efficacy for coping with results were associated with lower psychological distress and uncertainty, and higher hope and satisfaction with the decision to have CTGP (ps=0.001-0.047). Those with higher knowledge reported greater anxiety (p&#160;=&#160;0.034).&lt;bold&gt;Conclusion: &lt;/bold&gt;Receiving a non-actionable CTGP result, or an actionable result without ensured access to treatment, may cause increased distress in advanced cancer patients. Coping style was also associated with distress.&lt;bold&gt;Practice Implications: &lt;/bold&gt;Pre-testing assessment and counseling addressing attitudes toward uncertainty and self-efficacy, and post-CTGP result support for patients receiving a non-actionable result or who receive an actionable results without ensured access to treatment, may benefit patients. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Patient Education &amp; Counseling is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.pec.2022.01.011
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        Type: general
      – SubjectFull: Tumor treatment
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              Text: Jul2022
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