Racial Discrimination and Alcohol Problems: Examining Interactions with Genetic Risk and Impulsivity among African American Young Adults.

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Title: Racial Discrimination and Alcohol Problems: Examining Interactions with Genetic Risk and Impulsivity among African American Young Adults.
Authors: Su, Jinni1 jinnisu1@asu.edu, Trevino, Angel D.1, Kuo, Sally I-Chun2, Aliev, Fazil3,4, Williams, Chelsea Derlan3, Guy, Mignonne C.5, The Spit for Science Working Group, Dick, Danielle4, Amstadter, Ananda4, Lilley, Emily4, Gelzinis, Renolda4, Morris, Anne4, Bountress, Katie4, Adkins, Amy4, Thomas, Nathaniel4, Neale, Zoe4, Pedersen, Kimberly4, Bannard, Thomas4, Cho, Seung4, Barr, Peter4
Source: Journal of Youth & Adolescence. Aug2022, Vol. 51 Issue 8, p1552-1567. 16p. 5 Charts, 2 Graphs.
Subject Terms: *Adults, Saliva analysis, Racism, Genetics, Alcohol-induced disorders, Impulsive personality, Multiple regression analysis, Risk assessment, Genotypes, African Americans, Disease risk factors
Abstract: Experiences of racial discrimination have been shown to increase risk for alcohol problems. Some individuals may be particularly vulnerable to the negative effects of racial discrimination. However, little research has examined interaction effects between racial discrimination and individual characteristics, such as genetic predispositions and personality, in relation to alcohol outcomes. This study examined whether genetic risk and dimensions of impulsivity moderate the association between racial discrimination and alcohol problems among African American young adults (n = 383, Mage = 20.65, SD = 2.28; 81% female). Participants completed online surveys and provided a saliva sample for genotyping. Results from multiple regression analyses indicated that both blatant and subtle forms of racial discrimination (i.e., experience of racist events and racial microaggressions) were associated with more alcohol problems. Racial microaggressions interacted with dimensions of impulsivity in relation to alcohol problems, such that racial microaggressions were associated with more alcohol problems when negative urgency was high or when sensation seeking was low. There was no significant interaction between alcohol use disorder genome-wide polygenic score and experience of racist events or racial microaggression in relation to alcohol problems, which may partly reflect low power due in part to limited representation of African-Americans in genetic research. The findings highlight the need to increase the representation of African Americans in genetically-informed research in order to better characterize genetic risk and understand gene-environment interaction in this understudied population, as well as the importance of examining impulsivity as a multidimensional construct that interacts with racial discrimination in relation to alcohol outcomes. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Youth & Adolescence is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Racial Discrimination and Alcohol Problems: Examining Interactions with Genetic Risk and Impulsivity among African American Young Adults.
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  Data: <searchLink fieldCode="AR" term="%22Su%2C+Jinni%22">Su, Jinni</searchLink><relatesTo>1</relatesTo><i> jinnisu1@asu.edu</i><br /><searchLink fieldCode="AR" term="%22Trevino%2C+Angel+D%2E%22">Trevino, Angel D.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Kuo%2C+Sally+I-Chun%22">Kuo, Sally I-Chun</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Aliev%2C+Fazil%22">Aliev, Fazil</searchLink><relatesTo>3,4</relatesTo><br /><searchLink fieldCode="AR" term="%22Williams%2C+Chelsea+Derlan%22">Williams, Chelsea Derlan</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Guy%2C+Mignonne+C%2E%22">Guy, Mignonne C.</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22The+Spit+for+Science+Working+Group%22">The Spit for Science Working Group</searchLink><br /><searchLink fieldCode="AR" term="%22Dick%2C+Danielle%22">Dick, Danielle</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Amstadter%2C+Ananda%22">Amstadter, Ananda</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Lilley%2C+Emily%22">Lilley, Emily</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Gelzinis%2C+Renolda%22">Gelzinis, Renolda</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Morris%2C+Anne%22">Morris, Anne</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Bountress%2C+Katie%22">Bountress, Katie</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Adkins%2C+Amy%22">Adkins, Amy</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Thomas%2C+Nathaniel%22">Thomas, Nathaniel</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Neale%2C+Zoe%22">Neale, Zoe</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Pedersen%2C+Kimberly%22">Pedersen, Kimberly</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Bannard%2C+Thomas%22">Bannard, Thomas</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Cho%2C+Seung%22">Cho, Seung</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Barr%2C+Peter%22">Barr, Peter</searchLink><relatesTo>4</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Youth+%26+Adolescence%22">Journal of Youth & Adolescence</searchLink>. Aug2022, Vol. 51 Issue 8, p1552-1567. 16p. 5 Charts, 2 Graphs.
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  Data: *<searchLink fieldCode="DE" term="%22Adults%22">Adults</searchLink><br /><searchLink fieldCode="DE" term="%22Saliva+analysis%22">Saliva analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Racism%22">Racism</searchLink><br /><searchLink fieldCode="DE" term="%22Genetics%22">Genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Alcohol-induced+disorders%22">Alcohol-induced disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Impulsive+personality%22">Impulsive personality</searchLink><br /><searchLink fieldCode="DE" term="%22Multiple+regression+analysis%22">Multiple regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Risk+assessment%22">Risk assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Genotypes%22">Genotypes</searchLink><br /><searchLink fieldCode="DE" term="%22African+Americans%22">African Americans</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+risk+factors%22">Disease risk factors</searchLink>
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  Data: Experiences of racial discrimination have been shown to increase risk for alcohol problems. Some individuals may be particularly vulnerable to the negative effects of racial discrimination. However, little research has examined interaction effects between racial discrimination and individual characteristics, such as genetic predispositions and personality, in relation to alcohol outcomes. This study examined whether genetic risk and dimensions of impulsivity moderate the association between racial discrimination and alcohol problems among African American young adults (n = 383, Mage = 20.65, SD = 2.28; 81% female). Participants completed online surveys and provided a saliva sample for genotyping. Results from multiple regression analyses indicated that both blatant and subtle forms of racial discrimination (i.e., experience of racist events and racial microaggressions) were associated with more alcohol problems. Racial microaggressions interacted with dimensions of impulsivity in relation to alcohol problems, such that racial microaggressions were associated with more alcohol problems when negative urgency was high or when sensation seeking was low. There was no significant interaction between alcohol use disorder genome-wide polygenic score and experience of racist events or racial microaggression in relation to alcohol problems, which may partly reflect low power due in part to limited representation of African-Americans in genetic research. The findings highlight the need to increase the representation of African Americans in genetically-informed research in order to better characterize genetic risk and understand gene-environment interaction in this understudied population, as well as the importance of examining impulsivity as a multidimensional construct that interacts with racial discrimination in relation to alcohol outcomes. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Journal of Youth & Adolescence is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10964-022-01609-1
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        Text: English
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        Type: general
      – SubjectFull: Saliva analysis
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      – SubjectFull: Racism
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      – SubjectFull: African Americans
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      – SubjectFull: Disease risk factors
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