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Precision Medicine as a New Frontier in Speech-Language Pathology: How Applying Insights From Behavior Genomics Can Improve Outcomes in Communication Disorders.

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Title: Precision Medicine as a New Frontier in Speech-Language Pathology: How Applying Insights From Behavior Genomics Can Improve Outcomes in Communication Disorders.
Authors: Peter, Beate1 Beate.Peter@asu.edu, Bruce, Laurel1, Finestack, Lizbeth2, Dinu, Valentin1, Wilson, Melissa3, Klein-Seetharaman, Judith1, Lewis, Candace R.4,5, Braden, B. Blair1, Yi-Yuan Tang1, Scherer, Nancy1, VanDam, Mark6, Potterf, Nancy6
Source: American Journal of Speech-Language Pathology. Jul2023, Vol. 32 Issue 4, p1397-1412. 16p.
Subject Terms: *Speech therapy, *Behavior disorders in children, *Learning strategies, *Hearing disorders, *Language disorders, *Evaluation, *Children, Treatment of communicative disorders, Evaluation of medical care, Lifestyles, Disease progression, DNA, Genetic counselors, Individualized medicine, Ecology, Genetic variation, Genetic disorders, Genetic testing, Disease relapse, Health behavior, Genomics, Genotypes, Early medical intervention, Epigenomics, Disease risk factors
Abstract: Purpose: Precision medicine is an emerging intervention paradigm that leverages knowledge of risk factors such as genotypes, lifestyle, and environment toward proactive and personalized interventions. Regarding genetic risk factors, examples of interventions informed by the field of medical genomics are pharmacological interventions tailored to an individual’s genotype and anticipatory guidance for children whose hearing impairment is predicted to be progressive. Here, we show how principles of precision medicine and insights from behavior genomics have relevance for novel management strategies of behaviorally expressed disorders, especially disorders of spoken language. Method: This tutorial presents an overview of precision medicine, medical genomics, and behavior genomics; case examples of improved outcomes; and strategic goals toward enhancing clinical practice. Results: Speech-language pathologists (SLPs) see individuals with various communication disorders due to genetic variants. Ways of using insights from behavior genomics and implementing principles of precision medicine include recognizing early signs of undiagnosed genetic disorders in an individual’s communication patterns, making appropriate referrals to genetics professionals, and incorporating genetic findings into management plans. Patients benefit from a genetics diagnosis by gaining a deeper and more prognostic understanding of their condition, obtaining more precisely targeted interventions, and learning about their recurrence risks. Conclusions: SLPs can achieve improved outcomes by expanding their purview to include genetics. To drive this new interdisciplinary framework forward, goals should include systematic training in clinical genetics for SLPs, enhanced understanding of genotype–phenotype associations, leveraging insights from animal models, optimizing interprofessional team efforts, and developing novel proactive and personalized interventions. [ABSTRACT FROM AUTHOR]
Copyright of American Journal of Speech-Language Pathology is the property of American Speech-Language-Hearing Association and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Education Research Complete
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  Data: Precision Medicine as a New Frontier in Speech-Language Pathology: How Applying Insights From Behavior Genomics Can Improve Outcomes in Communication Disorders.
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  Data: <searchLink fieldCode="AR" term="%22Peter%2C+Beate%22">Peter, Beate</searchLink><relatesTo>1</relatesTo><i> Beate.Peter@asu.edu</i><br /><searchLink fieldCode="AR" term="%22Bruce%2C+Laurel%22">Bruce, Laurel</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Finestack%2C+Lizbeth%22">Finestack, Lizbeth</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Dinu%2C+Valentin%22">Dinu, Valentin</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Wilson%2C+Melissa%22">Wilson, Melissa</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Klein-Seetharaman%2C+Judith%22">Klein-Seetharaman, Judith</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Lewis%2C+Candace+R%2E%22">Lewis, Candace R.</searchLink><relatesTo>4,5</relatesTo><br /><searchLink fieldCode="AR" term="%22Braden%2C+B%2E+Blair%22">Braden, B. Blair</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Yi-Yuan+Tang%22">Yi-Yuan Tang</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Scherer%2C+Nancy%22">Scherer, Nancy</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22VanDam%2C+Mark%22">VanDam, Mark</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Potterf%2C+Nancy%22">Potterf, Nancy</searchLink><relatesTo>6</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22American+Journal+of+Speech-Language+Pathology%22">American Journal of Speech-Language Pathology</searchLink>. Jul2023, Vol. 32 Issue 4, p1397-1412. 16p.
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  Data: *<searchLink fieldCode="DE" term="%22Speech+therapy%22">Speech therapy</searchLink><br />*<searchLink fieldCode="DE" term="%22Behavior+disorders+in+children%22">Behavior disorders in children</searchLink><br />*<searchLink fieldCode="DE" term="%22Learning+strategies%22">Learning strategies</searchLink><br />*<searchLink fieldCode="DE" term="%22Hearing+disorders%22">Hearing disorders</searchLink><br />*<searchLink fieldCode="DE" term="%22Language+disorders%22">Language disorders</searchLink><br />*<searchLink fieldCode="DE" term="%22Evaluation%22">Evaluation</searchLink><br />*<searchLink fieldCode="DE" term="%22Children%22">Children</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+of+communicative+disorders%22">Treatment of communicative disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Evaluation+of+medical+care%22">Evaluation of medical care</searchLink><br /><searchLink fieldCode="DE" term="%22Lifestyles%22">Lifestyles</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+progression%22">Disease progression</searchLink><br /><searchLink fieldCode="DE" term="%22DNA%22">DNA</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+counselors%22">Genetic counselors</searchLink><br /><searchLink fieldCode="DE" term="%22Individualized+medicine%22">Individualized medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Ecology%22">Ecology</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+variation%22">Genetic variation</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+disorders%22">Genetic disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+testing%22">Genetic testing</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+relapse%22">Disease relapse</searchLink><br /><searchLink fieldCode="DE" term="%22Health+behavior%22">Health behavior</searchLink><br /><searchLink fieldCode="DE" term="%22Genomics%22">Genomics</searchLink><br /><searchLink fieldCode="DE" term="%22Genotypes%22">Genotypes</searchLink><br /><searchLink fieldCode="DE" term="%22Early+medical+intervention%22">Early medical intervention</searchLink><br /><searchLink fieldCode="DE" term="%22Epigenomics%22">Epigenomics</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+risk+factors%22">Disease risk factors</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Purpose: Precision medicine is an emerging intervention paradigm that leverages knowledge of risk factors such as genotypes, lifestyle, and environment toward proactive and personalized interventions. Regarding genetic risk factors, examples of interventions informed by the field of medical genomics are pharmacological interventions tailored to an individual’s genotype and anticipatory guidance for children whose hearing impairment is predicted to be progressive. Here, we show how principles of precision medicine and insights from behavior genomics have relevance for novel management strategies of behaviorally expressed disorders, especially disorders of spoken language. Method: This tutorial presents an overview of precision medicine, medical genomics, and behavior genomics; case examples of improved outcomes; and strategic goals toward enhancing clinical practice. Results: Speech-language pathologists (SLPs) see individuals with various communication disorders due to genetic variants. Ways of using insights from behavior genomics and implementing principles of precision medicine include recognizing early signs of undiagnosed genetic disorders in an individual’s communication patterns, making appropriate referrals to genetics professionals, and incorporating genetic findings into management plans. Patients benefit from a genetics diagnosis by gaining a deeper and more prognostic understanding of their condition, obtaining more precisely targeted interventions, and learning about their recurrence risks. Conclusions: SLPs can achieve improved outcomes by expanding their purview to include genetics. To drive this new interdisciplinary framework forward, goals should include systematic training in clinical genetics for SLPs, enhanced understanding of genotype–phenotype associations, leveraging insights from animal models, optimizing interprofessional team efforts, and developing novel proactive and personalized interventions. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of American Journal of Speech-Language Pathology is the property of American Speech-Language-Hearing Association and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=ehh&AN=164802901
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      – Type: doi
        Value: 10.1044/2023_AJSLP-22-00205
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      – Code: eng
        Text: English
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        PageCount: 16
        StartPage: 1397
    Subjects:
      – SubjectFull: Speech therapy
        Type: general
      – SubjectFull: Behavior disorders in children
        Type: general
      – SubjectFull: Learning strategies
        Type: general
      – SubjectFull: Hearing disorders
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      – SubjectFull: Language disorders
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      – SubjectFull: Evaluation
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      – SubjectFull: Treatment of communicative disorders
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      – SubjectFull: Evaluation of medical care
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      – SubjectFull: Lifestyles
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      – SubjectFull: Disease progression
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      – SubjectFull: DNA
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      – SubjectFull: Genetic counselors
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      – SubjectFull: Individualized medicine
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      – SubjectFull: Ecology
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      – SubjectFull: Genetic variation
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      – SubjectFull: Genetic disorders
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      – SubjectFull: Genetic testing
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      – SubjectFull: Genomics
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      – SubjectFull: Epigenomics
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      – TitleFull: Precision Medicine as a New Frontier in Speech-Language Pathology: How Applying Insights From Behavior Genomics Can Improve Outcomes in Communication Disorders.
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              Text: Jul2023
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