Mechanisms and Impact of Aminoglycoside-Induced Vestibular Deficits.
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| Title: | Mechanisms and Impact of Aminoglycoside-Induced Vestibular Deficits. |
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| Authors: | Janky, Kristen1, Steyger, Peter S.2 petersteyger@creighton.edu |
| Source: | American Journal of Audiology. Nov2023, Vol. 32, p746-760. 15p. |
| Subject Terms: | *Hearing disorders, Hair cells, Vestibular apparatus diseases, Aminoglycosides, Patient monitoring, Functional assessment |
| Abstract: | Purpose: Acquired vestibulotoxicity from hospital-prescribed medications such as aminoglycoside antibiotics affects as many as 40,000 people each year in North America. However, there are no current federally approved drugs to prevent or treat the debilitating and permanent loss of vestibular function caused by bactericidal aminoglycoside antibiotics. This review will cover our current understanding of the impact of, and mechanisms underlying, aminoglycoside-induced vestibulotoxicity and highlight the gaps in our knowledge that remain. Conclusions: Aminoglycoside-induced vestibular deficits have long-term impacts on patients across the lifespan. Additionally, the prevalence of aminoglycoside-induced vestibulotoxicity appears to be greater than cochleotoxicity. Thus, monitoring for vestibulotoxicity should be independent of auditory monitoring and encompass patients of all ages from young children to older adults before, during, and after aminoglycoside therapy. [ABSTRACT FROM AUTHOR] |
| Copyright of American Journal of Audiology is the property of American Speech-Language-Hearing Association and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Education Research Complete |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: ehh DbLabel: Education Research Complete An: 173375155 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Mechanisms and Impact of Aminoglycoside-Induced Vestibular Deficits. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Janky%2C+Kristen%22">Janky, Kristen</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Steyger%2C+Peter+S%2E%22">Steyger, Peter S.</searchLink><relatesTo>2</relatesTo><i> petersteyger@creighton.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22American+Journal+of+Audiology%22">American Journal of Audiology</searchLink>. Nov2023, Vol. 32, p746-760. 15p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22Hearing+disorders%22">Hearing disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Hair+cells%22">Hair cells</searchLink><br /><searchLink fieldCode="DE" term="%22Vestibular+apparatus+diseases%22">Vestibular apparatus diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Aminoglycosides%22">Aminoglycosides</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+monitoring%22">Patient monitoring</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+assessment%22">Functional assessment</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: Acquired vestibulotoxicity from hospital-prescribed medications such as aminoglycoside antibiotics affects as many as 40,000 people each year in North America. However, there are no current federally approved drugs to prevent or treat the debilitating and permanent loss of vestibular function caused by bactericidal aminoglycoside antibiotics. This review will cover our current understanding of the impact of, and mechanisms underlying, aminoglycoside-induced vestibulotoxicity and highlight the gaps in our knowledge that remain. Conclusions: Aminoglycoside-induced vestibular deficits have long-term impacts on patients across the lifespan. Additionally, the prevalence of aminoglycoside-induced vestibulotoxicity appears to be greater than cochleotoxicity. Thus, monitoring for vestibulotoxicity should be independent of auditory monitoring and encompass patients of all ages from young children to older adults before, during, and after aminoglycoside therapy. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of American Journal of Audiology is the property of American Speech-Language-Hearing Association and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1044/2023_AJA-22-00199 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 15 StartPage: 746 Subjects: – SubjectFull: Hearing disorders Type: general – SubjectFull: Hair cells Type: general – SubjectFull: Vestibular apparatus diseases Type: general – SubjectFull: Aminoglycosides Type: general – SubjectFull: Patient monitoring Type: general – SubjectFull: Functional assessment Type: general Titles: – TitleFull: Mechanisms and Impact of Aminoglycoside-Induced Vestibular Deficits. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Janky, Kristen – PersonEntity: Name: NameFull: Steyger, Peter S. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 10590889 Numbering: – Type: volume Value: 32 Titles: – TitleFull: American Journal of Audiology Type: main |
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