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Clinical Observations in Patients With Cystic Fibrosis--Related Diabetes and Self-Reported Ototoxicity Symptoms.

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Title: Clinical Observations in Patients With Cystic Fibrosis--Related Diabetes and Self-Reported Ototoxicity Symptoms.
Authors: Nichols, Nicole1, Rubenstein, Ronald C.2, Kelly, Andrea3, Vachhani, Jay J.1,4, Echaluse, Ma Vida1, Garinis, Angela Constance1,4 garinis@ohsu.edu
Source: American Journal of Audiology. Mar2024, Vol. 33 Issue 1, p283-291. 9p.
Subject Terms: *Treatment of hearing disorders, *Academic medical centers, *Self-evaluation, *Benchmarking (Management), *Comparative studies, Diabetes complications, Tinnitus, Glycosylated hemoglobin, Aminoglycosides, Respiratory infections, Acquisition of data, Vestibular apparatus diseases, Cystic fibrosis, Risk assessment, Treatment effectiveness, Severity of illness index, Ototoxicity, Medical records, Questionnaires, Descriptive statistics, Research funding, Glucose tolerance tests, Antibiotics, Disease management, Comorbidity, Disease complications
Geographic Terms: Oregon
Abstract: Purpose: Persons with cystic fibrosis (PwCF) are at high risk for ototoxicity due to the routine use of intravenous aminoglycoside (IV-AG) antibiotics in respiratory infection management. Additionally, factors that contribute to ototoxicity-related symptom development and severity in PwCF are unknown. Given the increased risk of ototoxicity in people with diabetes, we explored the association between cystic fibrosis--related diabetes (CFRD) and self-reported ototoxicity symptoms (tinnitus and vestibular problems) in PwCF treated with aminoglycosides. Method: PwCF (N = 39; 25 females, 14 males; Mage = 30.1 years, SD = 10.3) were recruited from the Cystic Fibrosis Care Center at Oregon Health & Science University. Patients completed the validated questionnaires to ascertain their experiences with ototoxicity-related symptoms of tinnitus and balance function. The diagnosis of CFRD, including oral glucose tolerance testing (OGTT), insulin treatment, hemoglobin A1c, and cumulative IV-AG treatment history, was obtained through a medical chart review. Participants were classified into three groups based on their medical diagnoses via OGTT: normal glucose tolerance (NGT; control; n = 16), abnormal glucose tolerance (AGT; n = 9), and CFRD (n = 14). Participants in each group were further classified based on survey outcomes for ototoxicity-related symptoms. Results: There was a trend toward a higher proportion of patients with CFRD reporting tinnitus compared to the AGT and NGT groups, but did not meet statistical significance (§² = 2.24, p = .13). Approximately, 43% of patients with CFRD reported experiencing clinically significant tinnitus lasting > 3 min compared to 11% in the AGT group and 13% in the NGT group (§² = 3.751, p = .05). Cumulative IV-AG exposure tended to be higher in CFRD compared to other groups. High balance function was generally reported in all groups. Conclusions: Patients with CFRD have greater ototoxicity-related symptoms. Further investigation of the relationship between CF-related comorbidities and the risk of developing ototoxicity-related symptoms is warranted to improve the detection and management of ototoxicity in PwCF. [ABSTRACT FROM AUTHOR]
Copyright of American Journal of Audiology is the property of American Speech-Language-Hearing Association and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Education Research Complete
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  Data: Clinical Observations in Patients With Cystic Fibrosis--Related Diabetes and Self-Reported Ototoxicity Symptoms.
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  Data: <searchLink fieldCode="JN" term="%22American+Journal+of+Audiology%22">American Journal of Audiology</searchLink>. Mar2024, Vol. 33 Issue 1, p283-291. 9p.
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  Data: *<searchLink fieldCode="DE" term="%22Treatment+of+hearing+disorders%22">Treatment of hearing disorders</searchLink><br />*<searchLink fieldCode="DE" term="%22Academic+medical+centers%22">Academic medical centers</searchLink><br />*<searchLink fieldCode="DE" term="%22Self-evaluation%22">Self-evaluation</searchLink><br />*<searchLink fieldCode="DE" term="%22Benchmarking+%28Management%29%22">Benchmarking (Management)</searchLink><br />*<searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Diabetes+complications%22">Diabetes complications</searchLink><br /><searchLink fieldCode="DE" term="%22Tinnitus%22">Tinnitus</searchLink><br /><searchLink fieldCode="DE" term="%22Glycosylated+hemoglobin%22">Glycosylated hemoglobin</searchLink><br /><searchLink fieldCode="DE" term="%22Aminoglycosides%22">Aminoglycosides</searchLink><br /><searchLink fieldCode="DE" term="%22Respiratory+infections%22">Respiratory infections</searchLink><br /><searchLink fieldCode="DE" term="%22Acquisition+of+data%22">Acquisition of data</searchLink><br /><searchLink fieldCode="DE" term="%22Vestibular+apparatus+diseases%22">Vestibular apparatus diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Cystic+fibrosis%22">Cystic fibrosis</searchLink><br /><searchLink fieldCode="DE" term="%22Risk+assessment%22">Risk assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Severity+of+illness+index%22">Severity of illness index</searchLink><br /><searchLink fieldCode="DE" term="%22Ototoxicity%22">Ototoxicity</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+records%22">Medical records</searchLink><br /><searchLink fieldCode="DE" term="%22Questionnaires%22">Questionnaires</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Glucose+tolerance+tests%22">Glucose tolerance tests</searchLink><br /><searchLink fieldCode="DE" term="%22Antibiotics%22">Antibiotics</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+management%22">Disease management</searchLink><br /><searchLink fieldCode="DE" term="%22Comorbidity%22">Comorbidity</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+complications%22">Disease complications</searchLink>
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  Label: Geographic Terms
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  Data: <searchLink fieldCode="DE" term="%22Oregon%22">Oregon</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: Persons with cystic fibrosis (PwCF) are at high risk for ototoxicity due to the routine use of intravenous aminoglycoside (IV-AG) antibiotics in respiratory infection management. Additionally, factors that contribute to ototoxicity-related symptom development and severity in PwCF are unknown. Given the increased risk of ototoxicity in people with diabetes, we explored the association between cystic fibrosis--related diabetes (CFRD) and self-reported ototoxicity symptoms (tinnitus and vestibular problems) in PwCF treated with aminoglycosides. Method: PwCF (N = 39; 25 females, 14 males; Mage = 30.1 years, SD = 10.3) were recruited from the Cystic Fibrosis Care Center at Oregon Health & Science University. Patients completed the validated questionnaires to ascertain their experiences with ototoxicity-related symptoms of tinnitus and balance function. The diagnosis of CFRD, including oral glucose tolerance testing (OGTT), insulin treatment, hemoglobin A1c, and cumulative IV-AG treatment history, was obtained through a medical chart review. Participants were classified into three groups based on their medical diagnoses via OGTT: normal glucose tolerance (NGT; control; n = 16), abnormal glucose tolerance (AGT; n = 9), and CFRD (n = 14). Participants in each group were further classified based on survey outcomes for ototoxicity-related symptoms. Results: There was a trend toward a higher proportion of patients with CFRD reporting tinnitus compared to the AGT and NGT groups, but did not meet statistical significance (§² = 2.24, p = .13). Approximately, 43% of patients with CFRD reported experiencing clinically significant tinnitus lasting > 3 min compared to 11% in the AGT group and 13% in the NGT group (§² = 3.751, p = .05). Cumulative IV-AG exposure tended to be higher in CFRD compared to other groups. High balance function was generally reported in all groups. Conclusions: Patients with CFRD have greater ototoxicity-related symptoms. Further investigation of the relationship between CF-related comorbidities and the risk of developing ototoxicity-related symptoms is warranted to improve the detection and management of ototoxicity in PwCF. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of American Journal of Audiology is the property of American Speech-Language-Hearing Association and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1044/2023_AJA-22-00237
    Languages:
      – Code: eng
        Text: English
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      Pagination:
        PageCount: 9
        StartPage: 283
    Subjects:
      – SubjectFull: Treatment of hearing disorders
        Type: general
      – SubjectFull: Academic medical centers
        Type: general
      – SubjectFull: Self-evaluation
        Type: general
      – SubjectFull: Benchmarking (Management)
        Type: general
      – SubjectFull: Comparative studies
        Type: general
      – SubjectFull: Diabetes complications
        Type: general
      – SubjectFull: Tinnitus
        Type: general
      – SubjectFull: Glycosylated hemoglobin
        Type: general
      – SubjectFull: Aminoglycosides
        Type: general
      – SubjectFull: Respiratory infections
        Type: general
      – SubjectFull: Acquisition of data
        Type: general
      – SubjectFull: Vestibular apparatus diseases
        Type: general
      – SubjectFull: Cystic fibrosis
        Type: general
      – SubjectFull: Risk assessment
        Type: general
      – SubjectFull: Treatment effectiveness
        Type: general
      – SubjectFull: Severity of illness index
        Type: general
      – SubjectFull: Ototoxicity
        Type: general
      – SubjectFull: Medical records
        Type: general
      – SubjectFull: Questionnaires
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Glucose tolerance tests
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      – SubjectFull: Antibiotics
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      – SubjectFull: Disease management
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      – SubjectFull: Comorbidity
        Type: general
      – SubjectFull: Disease complications
        Type: general
      – SubjectFull: Oregon
        Type: general
    Titles:
      – TitleFull: Clinical Observations in Patients With Cystic Fibrosis--Related Diabetes and Self-Reported Ototoxicity Symptoms.
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              Text: Mar2024
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