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Adverse events and contradictory effects of benzodiazepine in a case with intellectual disability and challenging behaviour.

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Title: Adverse events and contradictory effects of benzodiazepine in a case with intellectual disability and challenging behaviour.
Authors: Elbing, Ulrich1 info@dr-u-elbing.de, Appelbaum, Sebastian1, Ostermann, Thomas1
Source: Journal of Intellectual Disabilities. Mar2024, Vol. 28 Issue 1, p216-224. 9p.
Subject Terms: *Intellectual disabilities, Benzodiazepines, Markov processes
Abstract: This study aims to contribute to the knowledge about lacking or contradictory effects of benzodiazepine on hyperaroused or aggressive behaviour in persons with intellectual disability (ID). We conducted a retrospective and natural case study in a person with mild ID and multiple adverse childhood experiences (ACE), using routine diary data consisting of 275 days including 113 consecutive days under benzodiazepine medication. The medication effects were documented as "calm / relaxed", "fretful / distressed" and "sleep / doze". Transitions between these were modelled using Markov chains. Differences in transitions were analysed using Chi-Square test for homogeneity. The results show a significantly reduced stability of mood and increased distressed behaviour under benzodiazepine. This is in line with reports about the effects of psychotropic medication in patients with ID and challenging behaviour. Besides other influences on unexpected medication effects, a possible dissociative identity disorder is discussed as an additional explanation. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Intellectual Disabilities is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Education Research Complete
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Header DbId: ehh
DbLabel: Education Research Complete
An: 175845561
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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Items – Name: Title
  Label: Title
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  Data: Adverse events and contradictory effects of benzodiazepine in a case with intellectual disability and challenging behaviour.
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  Data: <searchLink fieldCode="AR" term="%22Elbing%2C+Ulrich%22">Elbing, Ulrich</searchLink><relatesTo>1</relatesTo><i> info@dr-u-elbing.de</i><br /><searchLink fieldCode="AR" term="%22Appelbaum%2C+Sebastian%22">Appelbaum, Sebastian</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Ostermann%2C+Thomas%22">Ostermann, Thomas</searchLink><relatesTo>1</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Intellectual+Disabilities%22">Journal of Intellectual Disabilities</searchLink>. Mar2024, Vol. 28 Issue 1, p216-224. 9p.
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  Data: *<searchLink fieldCode="DE" term="%22Intellectual+disabilities%22">Intellectual disabilities</searchLink><br /><searchLink fieldCode="DE" term="%22Benzodiazepines%22">Benzodiazepines</searchLink><br /><searchLink fieldCode="DE" term="%22Markov+processes%22">Markov processes</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: This study aims to contribute to the knowledge about lacking or contradictory effects of benzodiazepine on hyperaroused or aggressive behaviour in persons with intellectual disability (ID). We conducted a retrospective and natural case study in a person with mild ID and multiple adverse childhood experiences (ACE), using routine diary data consisting of 275 days including 113 consecutive days under benzodiazepine medication. The medication effects were documented as "calm / relaxed", "fretful / distressed" and "sleep / doze". Transitions between these were modelled using Markov chains. Differences in transitions were analysed using Chi-Square test for homogeneity. The results show a significantly reduced stability of mood and increased distressed behaviour under benzodiazepine. This is in line with reports about the effects of psychotropic medication in patients with ID and challenging behaviour. Besides other influences on unexpected medication effects, a possible dissociative identity disorder is discussed as an additional explanation. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Intellectual Disabilities is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=ehh&AN=175845561
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      – Type: doi
        Value: 10.1177/17446295221134420
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      – Code: eng
        Text: English
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        PageCount: 9
        StartPage: 216
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      – SubjectFull: Intellectual disabilities
        Type: general
      – SubjectFull: Benzodiazepines
        Type: general
      – SubjectFull: Markov processes
        Type: general
    Titles:
      – TitleFull: Adverse events and contradictory effects of benzodiazepine in a case with intellectual disability and challenging behaviour.
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            NameFull: Elbing, Ulrich
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            NameFull: Appelbaum, Sebastian
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            – D: 01
              M: 03
              Text: Mar2024
              Type: published
              Y: 2024
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              Value: 28
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