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Decoding Age-Linked Masseter Vestibular Evoked Myogenic Potential Changes in Healthy, Aging Individuals.

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Title: Decoding Age-Linked Masseter Vestibular Evoked Myogenic Potential Changes in Healthy, Aging Individuals.
Authors: Ramesh, Karan1, Thirunavukkarasu, Kumaran1 kumaran.aslp@gmail.com
Source: American Journal of Audiology. Sep2024, Vol. 33 Issue 3, p838-849. 12p.
Subject Terms: *Academic medical centers, Pearson correlation (Statistics), Masseter muscle, Sex distribution, Parameters (Statistics), Age distribution, Descriptive statistics, Bioelectric impedance, Multivariate analysis, Electromyography, Mathematical statistics, One-way analysis of variance, Analysis of variance, Acoustic stimulation, Data analysis software, Auditory evoked response, Vestibular function tests, Active aging, Nonparametric statistics
Abstract: Purpose: The primary objective of this study was to assess how age influences masseter vestibular evoked myogenic potential (mVEMP) parameters by utilizing 500-Hz tone burst stimuli delivered through air conduction. Method: The study involved 110 participants ranging from 15 to 60 years of age, grouped into five categories, all of whom had no previous issues related to their vestibular system. The participants were exposed to 500-Hz tone burst stimuli at 125 dB SPL through ER-3A inserts. These stimuli were presented to one ear at a time, with alternating polarity. A Tukey's honestly significant difference test was conducted to compare rectified and unrectified amplitude, along with latencies (P11 and N21) and the asymmetric ratio across all age groups. Additionally, a multivariate analysis of variance was performed to assess the impact of sex on the study variables. Results: All 110 participants (220 ears) in the study provided mVEMP responses, encompassing 100% of the subjects. The results revealed a significant reduction in both amplitude and latency extension for the P11 and N21 peaks. Interestingly, P11 latency was also prolonged in the youngest participants (Group 1), suggesting ongoing maturation of the system even beyond the age of 16 years. Moreover, a significant sex difference was observed in the P11 latencies. However, there were no substantial sex differences (p >.05)inN1peaklatency,peak-to- peak amplitude, rectified amplitude, and asymmetric ratio. Conclusions: Changes in structure occur due to degeneration, and the quantity of vestibular sensory hair cells gradually diminishes with age. The rate of decline is faster in semicircular canals compared to end organs, as observed by Merchant et al. (2000). Following a linear degeneration starting at the age of 40 years, a continuous reduction in sensory cells and primary neurons takes place until approximately 40% of vestibular sensory cells are lost by the age of 75 years and insufficient maturation can lead to prolonged peaks and reduced amplitudes compared with those that are considered normal. Therefore, it is crucial to consider the age of the participants when making diagnoses and incorporate relevant correction factors based on age-related reference data. [ABSTRACT FROM AUTHOR]
Copyright of American Journal of Audiology is the property of American Speech-Language-Hearing Association and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Education Research Complete
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  Data: Decoding Age-Linked Masseter Vestibular Evoked Myogenic Potential Changes in Healthy, Aging Individuals.
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  Data: <searchLink fieldCode="AR" term="%22Ramesh%2C+Karan%22">Ramesh, Karan</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Thirunavukkarasu%2C+Kumaran%22">Thirunavukkarasu, Kumaran</searchLink><relatesTo>1</relatesTo><i> kumaran.aslp@gmail.com</i>
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  Data: <searchLink fieldCode="JN" term="%22American+Journal+of+Audiology%22">American Journal of Audiology</searchLink>. Sep2024, Vol. 33 Issue 3, p838-849. 12p.
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  Data: *<searchLink fieldCode="DE" term="%22Academic+medical+centers%22">Academic medical centers</searchLink><br /><searchLink fieldCode="DE" term="%22Pearson+correlation+%28Statistics%29%22">Pearson correlation (Statistics)</searchLink><br /><searchLink fieldCode="DE" term="%22Masseter+muscle%22">Masseter muscle</searchLink><br /><searchLink fieldCode="DE" term="%22Sex+distribution%22">Sex distribution</searchLink><br /><searchLink fieldCode="DE" term="%22Parameters+%28Statistics%29%22">Parameters (Statistics)</searchLink><br /><searchLink fieldCode="DE" term="%22Age+distribution%22">Age distribution</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Bioelectric+impedance%22">Bioelectric impedance</searchLink><br /><searchLink fieldCode="DE" term="%22Multivariate+analysis%22">Multivariate analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Electromyography%22">Electromyography</searchLink><br /><searchLink fieldCode="DE" term="%22Mathematical+statistics%22">Mathematical statistics</searchLink><br /><searchLink fieldCode="DE" term="%22One-way+analysis+of+variance%22">One-way analysis of variance</searchLink><br /><searchLink fieldCode="DE" term="%22Analysis+of+variance%22">Analysis of variance</searchLink><br /><searchLink fieldCode="DE" term="%22Acoustic+stimulation%22">Acoustic stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Auditory+evoked+response%22">Auditory evoked response</searchLink><br /><searchLink fieldCode="DE" term="%22Vestibular+function+tests%22">Vestibular function tests</searchLink><br /><searchLink fieldCode="DE" term="%22Active+aging%22">Active aging</searchLink><br /><searchLink fieldCode="DE" term="%22Nonparametric+statistics%22">Nonparametric statistics</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: The primary objective of this study was to assess how age influences masseter vestibular evoked myogenic potential (mVEMP) parameters by utilizing 500-Hz tone burst stimuli delivered through air conduction. Method: The study involved 110 participants ranging from 15 to 60 years of age, grouped into five categories, all of whom had no previous issues related to their vestibular system. The participants were exposed to 500-Hz tone burst stimuli at 125 dB SPL through ER-3A inserts. These stimuli were presented to one ear at a time, with alternating polarity. A Tukey's honestly significant difference test was conducted to compare rectified and unrectified amplitude, along with latencies (P11 and N21) and the asymmetric ratio across all age groups. Additionally, a multivariate analysis of variance was performed to assess the impact of sex on the study variables. Results: All 110 participants (220 ears) in the study provided mVEMP responses, encompassing 100% of the subjects. The results revealed a significant reduction in both amplitude and latency extension for the P11 and N21 peaks. Interestingly, P11 latency was also prolonged in the youngest participants (Group 1), suggesting ongoing maturation of the system even beyond the age of 16 years. Moreover, a significant sex difference was observed in the P11 latencies. However, there were no substantial sex differences (p >.05)inN1peaklatency,peak-to- peak amplitude, rectified amplitude, and asymmetric ratio. Conclusions: Changes in structure occur due to degeneration, and the quantity of vestibular sensory hair cells gradually diminishes with age. The rate of decline is faster in semicircular canals compared to end organs, as observed by Merchant et al. (2000). Following a linear degeneration starting at the age of 40 years, a continuous reduction in sensory cells and primary neurons takes place until approximately 40% of vestibular sensory cells are lost by the age of 75 years and insufficient maturation can lead to prolonged peaks and reduced amplitudes compared with those that are considered normal. Therefore, it is crucial to consider the age of the participants when making diagnoses and incorporate relevant correction factors based on age-related reference data. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Group: Ab
  Data: <i>Copyright of American Journal of Audiology is the property of American Speech-Language-Hearing Association and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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    Identifiers:
      – Type: doi
        Value: 10.1044/2024_AJA-23-00264
    Languages:
      – Code: eng
        Text: English
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        PageCount: 12
        StartPage: 838
    Subjects:
      – SubjectFull: Academic medical centers
        Type: general
      – SubjectFull: Pearson correlation (Statistics)
        Type: general
      – SubjectFull: Masseter muscle
        Type: general
      – SubjectFull: Sex distribution
        Type: general
      – SubjectFull: Parameters (Statistics)
        Type: general
      – SubjectFull: Age distribution
        Type: general
      – SubjectFull: Descriptive statistics
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      – SubjectFull: Bioelectric impedance
        Type: general
      – SubjectFull: Multivariate analysis
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      – SubjectFull: Electromyography
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      – SubjectFull: Mathematical statistics
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      – SubjectFull: One-way analysis of variance
        Type: general
      – SubjectFull: Analysis of variance
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      – SubjectFull: Acoustic stimulation
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      – SubjectFull: Data analysis software
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      – SubjectFull: Auditory evoked response
        Type: general
      – SubjectFull: Vestibular function tests
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      – SubjectFull: Active aging
        Type: general
      – SubjectFull: Nonparametric statistics
        Type: general
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      – TitleFull: Decoding Age-Linked Masseter Vestibular Evoked Myogenic Potential Changes in Healthy, Aging Individuals.
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            NameFull: Ramesh, Karan
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            NameFull: Thirunavukkarasu, Kumaran
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              Text: Sep2024
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              Y: 2024
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