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Feasibility and preliminary efficacy of behavioral activation for treatment of depression in autistic adolescents.

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Title: Feasibility and preliminary efficacy of behavioral activation for treatment of depression in autistic adolescents.
Authors: Menezes, Michelle1 michelle.menezes@yale.edu, Burroughs, Christina2, Pappagianopoulos, Jessica3, Sadikova, Eleonora2,3, Fuhrmann, Emily3, Bohac, Genevieve3, Cross, Robert3, Witte, Lauren3, Brinkmann, Gabrielle3, Lemley, Rachel3, Sukhodolsky, Denis G1, Mazurek, Micah O3
Source: Autism: The International Journal of Research & Practice. Dec2024, Vol. 28 Issue 12, p3021-3032. 12p.
Subject Terms: *Anxiety, *Psychoeducation, *Pre-tests & post-tests, *Longitudinal method, *Behavior therapy, *Mental depression, *Autism in adolescence, *Social skills education, Research funding, T-test (Statistics), Pilot projects, Clinical trials, Treatment effectiveness, Asperger's syndrome in adolescence, Telepsychology, Social skills, Comorbidity
Abstract: Depression is common among autistic youth and is associated with worse quality of life in this group. Despite significant need for high-quality efficacious treatments, there has been very limited research on interventions for depression in autistic youth. This single-arm pilot study examined the feasibility and preliminary efficacy of a novel, behavior-based approach for treatment of depression symptoms in autistic adolescents without intellectual disability (i.e. Behavioral Activation for Autistic Adolescents, BA-A). BA-A is an individually delivered manualized 12-session treatment that utilizes established BA strategies and incorporates common mental health treatment adaptations for autistic young people. Of the 18 youth (11–16 years old) who enrolled, 15 completed all 12 treatment sessions, as well as pre-treatment, post-treatment, and follow-up assessment visits. Clinician treatment fidelity was quite high. Paired sample t -tests found that depression symptoms decreased pre- to post-BA-A according to multiple informants (i.e. self, caregiver, and independent evaluator), and treatment gains were maintained at 1-month follow-up. Paired sample t -tests also found that caregiver-reported anxiety symptoms and social skills improved pre-treatment to post-treatment. The results, although preliminary, indicate that BA-A may improve depression symptoms in autistic youth without intellectual disability. Furthermore, these promising findings suggest that a randomized controlled trial of BA-A is warranted. This trial was pre-registered at ClinicalTrials.gov (NCT05018169). Depression is common among autistic youth and has a significant negative impact on quality of life and day-to-day functioning. Despite great need for efficacious treatments, there are currently limited research-supported interventions for depression symptoms in autistic young people. This study tested a novel, behavior-based approach or psychotherapy for treatment of depression symptoms in autistic adolescents without intellectual disability (i.e. Behavioral Activation for Autistic Adolescents, BA-A) with 15 youth (11–16 years old). BA-A is an individually delivered 12-session therapy that was developed for and to meet the needs of autistic youth with depression. Results found that autistic youth and their caregivers were able to participate in BA-A therapy sessions, and clinicians were able to deliver BA-A in accordance with the treatment manual. Notably, results demonstrated that autistic youth depression symptoms significantly improved after participating in BA-A. Furthermore, anxiety symptoms and social skills significantly improved following BA-A. [ABSTRACT FROM AUTHOR]
Copyright of Autism: The International Journal of Research & Practice is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Education Research Complete
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  Data: Feasibility and preliminary efficacy of behavioral activation for treatment of depression in autistic adolescents.
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  Data: <searchLink fieldCode="AR" term="%22Menezes%2C+Michelle%22">Menezes, Michelle</searchLink><relatesTo>1</relatesTo><i> michelle.menezes@yale.edu</i><br /><searchLink fieldCode="AR" term="%22Burroughs%2C+Christina%22">Burroughs, Christina</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Pappagianopoulos%2C+Jessica%22">Pappagianopoulos, Jessica</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Sadikova%2C+Eleonora%22">Sadikova, Eleonora</searchLink><relatesTo>2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Fuhrmann%2C+Emily%22">Fuhrmann, Emily</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Bohac%2C+Genevieve%22">Bohac, Genevieve</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Cross%2C+Robert%22">Cross, Robert</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Witte%2C+Lauren%22">Witte, Lauren</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Brinkmann%2C+Gabrielle%22">Brinkmann, Gabrielle</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Lemley%2C+Rachel%22">Lemley, Rachel</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Sukhodolsky%2C+Denis+G%22">Sukhodolsky, Denis G</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Mazurek%2C+Micah+O%22">Mazurek, Micah O</searchLink><relatesTo>3</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Autism%3A+The+International+Journal+of+Research+%26+Practice%22">Autism: The International Journal of Research & Practice</searchLink>. Dec2024, Vol. 28 Issue 12, p3021-3032. 12p.
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  Data: *<searchLink fieldCode="DE" term="%22Anxiety%22">Anxiety</searchLink><br />*<searchLink fieldCode="DE" term="%22Psychoeducation%22">Psychoeducation</searchLink><br />*<searchLink fieldCode="DE" term="%22Pre-tests+%26+post-tests%22">Pre-tests & post-tests</searchLink><br />*<searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br />*<searchLink fieldCode="DE" term="%22Behavior+therapy%22">Behavior therapy</searchLink><br />*<searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br />*<searchLink fieldCode="DE" term="%22Autism+in+adolescence%22">Autism in adolescence</searchLink><br />*<searchLink fieldCode="DE" term="%22Social+skills+education%22">Social skills education</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22T-test+%28Statistics%29%22">T-test (Statistics)</searchLink><br /><searchLink fieldCode="DE" term="%22Pilot+projects%22">Pilot projects</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+trials%22">Clinical trials</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Asperger's+syndrome+in+adolescence%22">Asperger's syndrome in adolescence</searchLink><br /><searchLink fieldCode="DE" term="%22Telepsychology%22">Telepsychology</searchLink><br /><searchLink fieldCode="DE" term="%22Social+skills%22">Social skills</searchLink><br /><searchLink fieldCode="DE" term="%22Comorbidity%22">Comorbidity</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Depression is common among autistic youth and is associated with worse quality of life in this group. Despite significant need for high-quality efficacious treatments, there has been very limited research on interventions for depression in autistic youth. This single-arm pilot study examined the feasibility and preliminary efficacy of a novel, behavior-based approach for treatment of depression symptoms in autistic adolescents without intellectual disability (i.e. Behavioral Activation for Autistic Adolescents, BA-A). BA-A is an individually delivered manualized 12-session treatment that utilizes established BA strategies and incorporates common mental health treatment adaptations for autistic young people. Of the 18 youth (11–16 years old) who enrolled, 15 completed all 12 treatment sessions, as well as pre-treatment, post-treatment, and follow-up assessment visits. Clinician treatment fidelity was quite high. Paired sample t -tests found that depression symptoms decreased pre- to post-BA-A according to multiple informants (i.e. self, caregiver, and independent evaluator), and treatment gains were maintained at 1-month follow-up. Paired sample t -tests also found that caregiver-reported anxiety symptoms and social skills improved pre-treatment to post-treatment. The results, although preliminary, indicate that BA-A may improve depression symptoms in autistic youth without intellectual disability. Furthermore, these promising findings suggest that a randomized controlled trial of BA-A is warranted. This trial was pre-registered at ClinicalTrials.gov (NCT05018169). Depression is common among autistic youth and has a significant negative impact on quality of life and day-to-day functioning. Despite great need for efficacious treatments, there are currently limited research-supported interventions for depression symptoms in autistic young people. This study tested a novel, behavior-based approach or psychotherapy for treatment of depression symptoms in autistic adolescents without intellectual disability (i.e. Behavioral Activation for Autistic Adolescents, BA-A) with 15 youth (11–16 years old). BA-A is an individually delivered 12-session therapy that was developed for and to meet the needs of autistic youth with depression. Results found that autistic youth and their caregivers were able to participate in BA-A therapy sessions, and clinicians were able to deliver BA-A in accordance with the treatment manual. Notably, results demonstrated that autistic youth depression symptoms significantly improved after participating in BA-A. Furthermore, anxiety symptoms and social skills significantly improved following BA-A. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Autism: The International Journal of Research & Practice is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=ehh&AN=180988100
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        Value: 10.1177/13623613241252470
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        Text: English
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      – SubjectFull: Anxiety
        Type: general
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      – SubjectFull: Pre-tests & post-tests
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      – SubjectFull: Longitudinal method
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      – SubjectFull: Mental depression
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      – SubjectFull: Autism in adolescence
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      – SubjectFull: T-test (Statistics)
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