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Impact of low-dose aspirin on the prevalence of anemia in elderly patients: a systematic review and meta-analysis.

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Title: Impact of low-dose aspirin on the prevalence of anemia in elderly patients: a systematic review and meta-analysis.
Authors: Martins Prizão, Vitória1 (AUTHOR) vitoriamprizao@gmail.com, de Moura de Souza, Mariana2 (AUTHOR), de Athayde De Hollanda Morais, Beatriz Austregésilo3 (AUTHOR), Ximenes Mendes, Beatriz4 (AUTHOR), Cosendey Martins, Otávio5 (AUTHOR), Defante, Maria Luiza Rodrigues6 (AUTHOR), Queiroz Vasconcelos Muniz, Juliana7 (AUTHOR), Francisco Buzetti Spinelli, Bruno8 (AUTHOR)
Source: Postgraduate Medicine. Mar2025, Vol. 137 Issue 2, p148-154. 7p.
Subject Terms: Older patients, Aspirin, Older people, Odds ratio, Hemoglobins
Abstract: Background: Aspirin is largely used for cardiovascular prevention. While its adverse effect on bleeding is well-documented, the prevalence of anemia remains uncertain. We conducted a meta-analysis on how low-dose aspirin affects hemoglobin and other hematologic parameters in the elderly. Methods: We systematically searched PubMed, Embase, and Cochrane for studies comparing the hematological parameters and the prevalence of anemia between low-dose aspirin (≤325 mg) and non-aspirin users in individuals aged older than 60 years. We pooled mean differences (MD) for continuous outcomes and odds ratio (OR) for binary outcomes, with 95% confidence intervals (CI), under a random-effects model for both. Results: Seven studies were included, including three randomized controlled trials (RCTs), totaling 19,792 participants. Among them, 9,771 (49.3%) were treated with aspirin; 55.4% were women and 44% had a history of smoking. There was no significant difference in anemia prevalence (OR 0.85; 95% CI 0.52–1.38; p = 0.50). Mean Corpuscular Hemoglobin (MD 0.06 pg; 95% CI −0.37 to 0.49; p = 0.79), Mean Corpuscular Volume (MD −0.31 fl; 95% CI −1.17 to 0.56; p = 0.49), and hemoglobin concentration (MD −0.02 g/dL; 95% CI −0.26 to 0.21; p = 0.85) between the two groups. However, hemoglobin decline from baseline was higher in aspirin users (MD −0.11 g/dL; 95% CI −0.17 to −0.05; p = 0.0002; I2 = 0%). Discussion: Our study employs rigorous methodology and a substantial patient cohort, marking the first quantitative meta-analysis in the past decade. Limitations include diverse study designs, short follow-up durations, gender-specific anemia criteria, and insufficient ferritin and iron levels data. Nonetheless, our findings suggest that while low-dose aspirin does not increase anemia prevalence, it is associated with declining hemoglobin levels over time. [ABSTRACT FROM AUTHOR]
Copyright of Postgraduate Medicine is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Impact of low-dose aspirin on the prevalence of anemia in elderly patients: a systematic review and meta-analysis.
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  Data: <searchLink fieldCode="AR" term="%22Martins+Prizão%2C+Vitória%22">Martins Prizão, Vitória</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> vitoriamprizao@gmail.com</i><br /><searchLink fieldCode="AR" term="%22de+Moura+de+Souza%2C+Mariana%22">de Moura de Souza, Mariana</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+Athayde+De+Hollanda+Morais%2C+Beatriz+Austregésilo%22">de Athayde De Hollanda Morais, Beatriz Austregésilo</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ximenes+Mendes%2C+Beatriz%22">Ximenes Mendes, Beatriz</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cosendey+Martins%2C+Otávio%22">Cosendey Martins, Otávio</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Defante%2C+Maria+Luiza+Rodrigues%22">Defante, Maria Luiza Rodrigues</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Queiroz+Vasconcelos+Muniz%2C+Juliana%22">Queiroz Vasconcelos Muniz, Juliana</searchLink><relatesTo>7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Francisco+Buzetti+Spinelli%2C+Bruno%22">Francisco Buzetti Spinelli, Bruno</searchLink><relatesTo>8</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Postgraduate+Medicine%22">Postgraduate Medicine</searchLink>. Mar2025, Vol. 137 Issue 2, p148-154. 7p.
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  Data: <searchLink fieldCode="DE" term="%22Older+patients%22">Older patients</searchLink><br /><searchLink fieldCode="DE" term="%22Aspirin%22">Aspirin</searchLink><br /><searchLink fieldCode="DE" term="%22Older+people%22">Older people</searchLink><br /><searchLink fieldCode="DE" term="%22Odds+ratio%22">Odds ratio</searchLink><br /><searchLink fieldCode="DE" term="%22Hemoglobins%22">Hemoglobins</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Aspirin is largely used for cardiovascular prevention. While its adverse effect on bleeding is well-documented, the prevalence of anemia remains uncertain. We conducted a meta-analysis on how low-dose aspirin affects hemoglobin and other hematologic parameters in the elderly. Methods: We systematically searched PubMed, Embase, and Cochrane for studies comparing the hematological parameters and the prevalence of anemia between low-dose aspirin (≤325 mg) and non-aspirin users in individuals aged older than 60 years. We pooled mean differences (MD) for continuous outcomes and odds ratio (OR) for binary outcomes, with 95% confidence intervals (CI), under a random-effects model for both. Results: Seven studies were included, including three randomized controlled trials (RCTs), totaling 19,792 participants. Among them, 9,771 (49.3%) were treated with aspirin; 55.4% were women and 44% had a history of smoking. There was no significant difference in anemia prevalence (OR 0.85; 95% CI 0.52–1.38; p = 0.50). Mean Corpuscular Hemoglobin (MD 0.06 pg; 95% CI −0.37 to 0.49; p = 0.79), Mean Corpuscular Volume (MD −0.31 fl; 95% CI −1.17 to 0.56; p = 0.49), and hemoglobin concentration (MD −0.02 g/dL; 95% CI −0.26 to 0.21; p = 0.85) between the two groups. However, hemoglobin decline from baseline was higher in aspirin users (MD −0.11 g/dL; 95% CI −0.17 to −0.05; p = 0.0002; I2 = 0%). Discussion: Our study employs rigorous methodology and a substantial patient cohort, marking the first quantitative meta-analysis in the past decade. Limitations include diverse study designs, short follow-up durations, gender-specific anemia criteria, and insufficient ferritin and iron levels data. Nonetheless, our findings suggest that while low-dose aspirin does not increase anemia prevalence, it is associated with declining hemoglobin levels over time. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Postgraduate Medicine is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1080/00325481.2024.2446010
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      – Code: eng
        Text: English
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        PageCount: 7
        StartPage: 148
    Subjects:
      – SubjectFull: Older patients
        Type: general
      – SubjectFull: Aspirin
        Type: general
      – SubjectFull: Older people
        Type: general
      – SubjectFull: Odds ratio
        Type: general
      – SubjectFull: Hemoglobins
        Type: general
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              M: 03
              Text: Mar2025
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