View in EDS HTML Full Text PDF Full Text

Sex-Dependent Effects of MAOA Genotypes on the Relations Between Childhood Sexual Abuse, Aggression, and Cannabis Use in Emerging Adults.

Saved in:
Bibliographic Details
Title: Sex-Dependent Effects of MAOA Genotypes on the Relations Between Childhood Sexual Abuse, Aggression, and Cannabis Use in Emerging Adults.
Authors: Fite, Paula J1 pfite@ku.edu, Ryder, Annie L1, Baca, Selena1, Hossain, Waheeda A.2, Manzardo, Ann2, Butler, Merlin G2, Bortolato, Marco3,4
Source: Journal of Child Sexual Abuse. May2025, Vol. 34 Issue 4, p386-403. 18p.
Subject Terms: *Academic medical centers, *Psychological adaptation, *Retrospective studies, *Child sexual abuse, *Aggression (Psychology), *Comparative studies, Adult child abuse victims, Research funding, Sex distribution, Questionnaires, Research evaluation, Multiple regression analysis, Descriptive statistics, Monoamine oxidase inhibitors, Surveys, Race, Medical records, Acquisition of data, Cannabis (Genus), Data analysis software, Genotypes, Psychosocial factors
Abstract: Cannabis use and aggression share common vulnerability factors, including childhood sexual abuse. While genetic predispositions likely shape the association between aggression and cannabis use, specific genes have not been conclusively identified. The underlying causal pathways connecting childhood sexual abuse to both cannabis use and aggression remain poorly understood. Prior research suggests that the MAOA (Monoamine oxidase A) gene interacts with childhood maltreatment to predispose young adults to aggression and substance use. Building on this premise, a preexisting dataset of 498 emerging adults was utilized to investigate whether different MAOA genotypes interact with sexual abuse during childhood to predispose to cannabis use as a means of coping with negative affect and impact aggression levels. Participants underwent genotyping for MAOA alleles associated with either low (MAOA-L) or high (MAOA-H) enzyme activity. They were also surveyed for childhood sex abuse, reactive and proactive aggression, and cannabis use. Among male carriers of MAOA-L variants who described experiencing childhood sexual abuse, those who used cannabis reported a higher likelihood of doing so for coping purposes compared to other males and all females. Surprisingly, MAOA-L genotypes in males appeared to buffer the impact of sexual abuse and high cannabis consumption on various measures of aggression. These findings underscore the complex role of MAOA in moderating the relationship between trauma, substance use, and aggression. If validated by further studies, these results could inform the development of targeted pharmacological and behavioral treatments for individuals with trauma histories and genetic predispositions to aggression. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Child Sexual Abuse is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Education Research Complete
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: ehh
DbLabel: Education Research Complete
An: 187280563
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Sex-Dependent Effects of MAOA Genotypes on the Relations Between Childhood Sexual Abuse, Aggression, and Cannabis Use in Emerging Adults.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Fite%2C+Paula+J%22">Fite, Paula J</searchLink><relatesTo>1</relatesTo><i> pfite@ku.edu</i><br /><searchLink fieldCode="AR" term="%22Ryder%2C+Annie+L%22">Ryder, Annie L</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Baca%2C+Selena%22">Baca, Selena</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Hossain%2C+Waheeda+A%2E%22">Hossain, Waheeda A.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Manzardo%2C+Ann%22">Manzardo, Ann</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Butler%2C+Merlin+G%22">Butler, Merlin G</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Bortolato%2C+Marco%22">Bortolato, Marco</searchLink><relatesTo>3,4</relatesTo>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Journal+of+Child+Sexual+Abuse%22">Journal of Child Sexual Abuse</searchLink>. May2025, Vol. 34 Issue 4, p386-403. 18p.
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: *<searchLink fieldCode="DE" term="%22Academic+medical+centers%22">Academic medical centers</searchLink><br />*<searchLink fieldCode="DE" term="%22Psychological+adaptation%22">Psychological adaptation</searchLink><br />*<searchLink fieldCode="DE" term="%22Retrospective+studies%22">Retrospective studies</searchLink><br />*<searchLink fieldCode="DE" term="%22Child+sexual+abuse%22">Child sexual abuse</searchLink><br />*<searchLink fieldCode="DE" term="%22Aggression+%28Psychology%29%22">Aggression (Psychology)</searchLink><br />*<searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Adult+child+abuse+victims%22">Adult child abuse victims</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Sex+distribution%22">Sex distribution</searchLink><br /><searchLink fieldCode="DE" term="%22Questionnaires%22">Questionnaires</searchLink><br /><searchLink fieldCode="DE" term="%22Research+evaluation%22">Research evaluation</searchLink><br /><searchLink fieldCode="DE" term="%22Multiple+regression+analysis%22">Multiple regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Monoamine+oxidase+inhibitors%22">Monoamine oxidase inhibitors</searchLink><br /><searchLink fieldCode="DE" term="%22Surveys%22">Surveys</searchLink><br /><searchLink fieldCode="DE" term="%22Race%22">Race</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+records%22">Medical records</searchLink><br /><searchLink fieldCode="DE" term="%22Acquisition+of+data%22">Acquisition of data</searchLink><br /><searchLink fieldCode="DE" term="%22Cannabis+%28Genus%29%22">Cannabis (Genus)</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Genotypes%22">Genotypes</searchLink><br /><searchLink fieldCode="DE" term="%22Psychosocial+factors%22">Psychosocial factors</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Cannabis use and aggression share common vulnerability factors, including childhood sexual abuse. While genetic predispositions likely shape the association between aggression and cannabis use, specific genes have not been conclusively identified. The underlying causal pathways connecting childhood sexual abuse to both cannabis use and aggression remain poorly understood. Prior research suggests that the MAOA (Monoamine oxidase A) gene interacts with childhood maltreatment to predispose young adults to aggression and substance use. Building on this premise, a preexisting dataset of 498 emerging adults was utilized to investigate whether different MAOA genotypes interact with sexual abuse during childhood to predispose to cannabis use as a means of coping with negative affect and impact aggression levels. Participants underwent genotyping for MAOA alleles associated with either low (MAOA-L) or high (MAOA-H) enzyme activity. They were also surveyed for childhood sex abuse, reactive and proactive aggression, and cannabis use. Among male carriers of MAOA-L variants who described experiencing childhood sexual abuse, those who used cannabis reported a higher likelihood of doing so for coping purposes compared to other males and all females. Surprisingly, MAOA-L genotypes in males appeared to buffer the impact of sexual abuse and high cannabis consumption on various measures of aggression. These findings underscore the complex role of MAOA in moderating the relationship between trauma, substance use, and aggression. If validated by further studies, these results could inform the development of targeted pharmacological and behavioral treatments for individuals with trauma histories and genetic predispositions to aggression. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Child Sexual Abuse is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=ehh&AN=187280563
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/10538712.2025.2519575
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 18
        StartPage: 386
    Subjects:
      – SubjectFull: Academic medical centers
        Type: general
      – SubjectFull: Psychological adaptation
        Type: general
      – SubjectFull: Retrospective studies
        Type: general
      – SubjectFull: Child sexual abuse
        Type: general
      – SubjectFull: Aggression (Psychology)
        Type: general
      – SubjectFull: Comparative studies
        Type: general
      – SubjectFull: Adult child abuse victims
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Sex distribution
        Type: general
      – SubjectFull: Questionnaires
        Type: general
      – SubjectFull: Research evaluation
        Type: general
      – SubjectFull: Multiple regression analysis
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Monoamine oxidase inhibitors
        Type: general
      – SubjectFull: Surveys
        Type: general
      – SubjectFull: Race
        Type: general
      – SubjectFull: Medical records
        Type: general
      – SubjectFull: Acquisition of data
        Type: general
      – SubjectFull: Cannabis (Genus)
        Type: general
      – SubjectFull: Data analysis software
        Type: general
      – SubjectFull: Genotypes
        Type: general
      – SubjectFull: Psychosocial factors
        Type: general
    Titles:
      – TitleFull: Sex-Dependent Effects of MAOA Genotypes on the Relations Between Childhood Sexual Abuse, Aggression, and Cannabis Use in Emerging Adults.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Fite, Paula J
      – PersonEntity:
          Name:
            NameFull: Ryder, Annie L
      – PersonEntity:
          Name:
            NameFull: Baca, Selena
      – PersonEntity:
          Name:
            NameFull: Hossain, Waheeda A.
      – PersonEntity:
          Name:
            NameFull: Manzardo, Ann
      – PersonEntity:
          Name:
            NameFull: Butler, Merlin G
      – PersonEntity:
          Name:
            NameFull: Bortolato, Marco
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: May2025
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-print
              Value: 10538712
          Numbering:
            – Type: volume
              Value: 34
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: Journal of Child Sexual Abuse
              Type: main
ResultId 1