Systematic review and meta-analysis of combined cognitive-behavioral therapy and physical activity and exercise interventions for pediatric chronic disease.

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Title: Systematic review and meta-analysis of combined cognitive-behavioral therapy and physical activity and exercise interventions for pediatric chronic disease.
Authors: Black, William R1,2 (AUTHOR), Klinggraeff, Lauren von3 (AUTHOR), White, David A4,5 (AUTHOR), Forseth, Bethany5,6 (AUTHOR), Jackson, Jamie L1,2 (AUTHOR), Bates, Carolyn R5,7 (AUTHOR), Pfledderer, Christopher D8,9 (AUTHOR), Dobbins, Sidney1 (AUTHOR), Hoskinson, Kristen R1,2 (AUTHOR), Gehred, Alison1 (AUTHOR), Davis, Ann M5,7 (AUTHOR)
Source: Journal of Pediatric Psychology. Jul2025, Vol. 50 Issue 7, p620-632. 13p.
Subject Terms: *Cognitive therapy, *Comparative studies, Physical activity, Exercise therapy, Juvenile diseases, Health outcome assessment, Clinical trials
Abstract: Objective Cognitive-behavioral (CBT) interventions combined with either a physical activity (CBT+PA) or exercise intervention (CBT+Ex) are becoming more common in pediatric populations. Considering the independent effects of PA and exercise on health and psychological outcomes, it is unclear whether CBT alone differs from CBT+PA or CBT+Ex in efficacy. The main objective of this systematic review and meta-analysis of randomized clinical trials (RCTs) was to assess the efficacy of CBT+PA and CBT+Ex interventions in pediatric chronic disease. Method This review included RCTs in children (≤18 years) with a chronic condition, a CBT+Ex or CBT+PA intervention, and an objective measure of PA&Ex. Seven databases were searched using MeSH terms and key terms and included studies published before July 1, 2023. Abstracts were reviewed for inclusion by two independent reviewers, data was extracted by three independent reviewers. Risk of bias (RoB 2) and study quality were coded. Random effect meta-analyses of differences in between-group change in PA&Ex were conducted. Results Eligible studies (k  = 5) reported outcomes for a combined 446 children. A small, nonsignificant overall effect was found (d =  0.10, 95% CI −0.16, 0.35) indicating intervention groups (CBT+PA or CBT+Ex) increased engagement in PA&Ex more than comparator groups (CBT). Additional analyses were inconclusive due to the small number of eligible studies. Discussion Additional RCTs are needed with integrated PA&Ex interventions targeting pediatric chronic disease. Future trials should report more detailed PA&Ex data. The full protocol for this analysis was prospectively registered in Open Science Framework (project ID: osf.io/m4wtc). [ABSTRACT FROM AUTHOR]
Copyright of Journal of Pediatric Psychology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Systematic review and meta-analysis of combined cognitive-behavioral therapy and physical activity and exercise interventions for pediatric chronic disease.
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  Data: <searchLink fieldCode="AR" term="%22Black%2C+William+R%22">Black, William R</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Klinggraeff%2C+Lauren+von%22">Klinggraeff, Lauren von</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22White%2C+David+A%22">White, David A</searchLink><relatesTo>4,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Forseth%2C+Bethany%22">Forseth, Bethany</searchLink><relatesTo>5,6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jackson%2C+Jamie+L%22">Jackson, Jamie L</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bates%2C+Carolyn+R%22">Bates, Carolyn R</searchLink><relatesTo>5,7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pfledderer%2C+Christopher+D%22">Pfledderer, Christopher D</searchLink><relatesTo>8,9</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dobbins%2C+Sidney%22">Dobbins, Sidney</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hoskinson%2C+Kristen+R%22">Hoskinson, Kristen R</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gehred%2C+Alison%22">Gehred, Alison</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Davis%2C+Ann+M%22">Davis, Ann M</searchLink><relatesTo>5,7</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Pediatric+Psychology%22">Journal of Pediatric Psychology</searchLink>. Jul2025, Vol. 50 Issue 7, p620-632. 13p.
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  Data: *<searchLink fieldCode="DE" term="%22Cognitive+therapy%22">Cognitive therapy</searchLink><br />*<searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Physical+activity%22">Physical activity</searchLink><br /><searchLink fieldCode="DE" term="%22Exercise+therapy%22">Exercise therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Juvenile+diseases%22">Juvenile diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Health+outcome+assessment%22">Health outcome assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+trials%22">Clinical trials</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Objective Cognitive-behavioral (CBT) interventions combined with either a physical activity (CBT+PA) or exercise intervention (CBT+Ex) are becoming more common in pediatric populations. Considering the independent effects of PA and exercise on health and psychological outcomes, it is unclear whether CBT alone differs from CBT+PA or CBT+Ex in efficacy. The main objective of this systematic review and meta-analysis of randomized clinical trials (RCTs) was to assess the efficacy of CBT+PA and CBT+Ex interventions in pediatric chronic disease. Method This review included RCTs in children (≤18 years) with a chronic condition, a CBT+Ex or CBT+PA intervention, and an objective measure of PA&Ex. Seven databases were searched using MeSH terms and key terms and included studies published before July 1, 2023. Abstracts were reviewed for inclusion by two independent reviewers, data was extracted by three independent reviewers. Risk of bias (RoB 2) and study quality were coded. Random effect meta-analyses of differences in between-group change in PA&Ex were conducted. Results Eligible studies (k  = 5) reported outcomes for a combined 446 children. A small, nonsignificant overall effect was found (d =  0.10, 95% CI −0.16, 0.35) indicating intervention groups (CBT+PA or CBT+Ex) increased engagement in PA&Ex more than comparator groups (CBT). Additional analyses were inconclusive due to the small number of eligible studies. Discussion Additional RCTs are needed with integrated PA&Ex interventions targeting pediatric chronic disease. Future trials should report more detailed PA&Ex data. The full protocol for this analysis was prospectively registered in Open Science Framework (project ID: osf.io/m4wtc). [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Journal of Pediatric Psychology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1093/jpepsy/jsae087
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      – Code: eng
        Text: English
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        PageCount: 13
        StartPage: 620
    Subjects:
      – SubjectFull: Cognitive therapy
        Type: general
      – SubjectFull: Comparative studies
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      – SubjectFull: Physical activity
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      – SubjectFull: Exercise therapy
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      – SubjectFull: Juvenile diseases
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      – SubjectFull: Health outcome assessment
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              Text: Jul2025
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