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Sleep in Infants with Down Syndrome or Familial Likelihood of Autism in the First Year of Life.

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Title: Sleep in Infants with Down Syndrome or Familial Likelihood of Autism in the First Year of Life.
Authors: Coco, Emma R.1 (AUTHOR), Munson, Jeffrey1,2 (AUTHOR), John, Tanya St.1,3 (AUTHOR), Dager, Stephen R.1,4 (AUTHOR), Botteron, Kelly5 (AUTHOR), Elison, Jed6 (AUTHOR), Garic, Dea7 (AUTHOR), Hazlett, Heather7 (AUTHOR), Lee, Chimei6 (AUTHOR), Marrus, Natasha5 (AUTHOR), Pruett Jr., John R.5 (AUTHOR), Schultz, Robert8 (AUTHOR), Shen, Mark7 (AUTHOR), Zwaigenbaum, Lonnie9 (AUTHOR), Piven, Joseph7 (AUTHOR), Estes, Annette1,3 (AUTHOR) estesa@uw.edu
Source: Journal of Autism & Developmental Disorders. Dec2025, Vol. 55 Issue 12, p4439-4449. 11p.
Subject Terms: *Down syndrome, *Academic medical centers, *Longitudinal method, *Research, *Asperger's syndrome, *Comparative studies, *Children, Genetics of autism, Risk assessment, Questionnaires, Neurological disorders, Sleep, Sleep disorders, Wakefulness, Genetic testing, Disease risk factors, Disease complications
Geographic Terms: United States
Abstract: Sleep problems have been associated with atypical development, but there is limited understanding of when sleep problems arise and how they differ across clinical populations. We aimed to evaluate sleep characteristics of infants with Down syndrome (DS), higher familial likelihood of autism (HL) and lower familial likelihood of autism (LL) at 6 and 12 months of age. Participants were from two longitudinal, multi-site, studies. Sleep was estimated by parent report on the Brief Infant Sleep Questionnaire at 6 months (59 DS, 173 HL, 54 LL); 12 months (58 DS, 129 HL, 30 LL); and in a longitudinal subset at both 6 and 12 months (100 HL; 23 LL; 33 DS). At 6-months, DS parents reported less concern about infant sleep and less night wakefulness than LL parents; HL parents reported longer sleep onset latency (SOL). At 12 months DS parents reported less night sleep and more night wakefulness; HL parents reported less night sleep, more night wakefulness and longer SOL compared to LL. Night wakefulness increased significantly in the DS and HL groups from 6 to 12 months of age. A higher proportion of DS and HL infants decreased Night Sleep and increased Night Wakefulness compared with the LL group. A higher proportion of DS infants increased SOL compared with the LL group. Sleep alterations are present in the first year of life and may differ in DS and HL infants. The mechanisms behind these sleep alterations may be an important early intervention target. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Autism & Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Education Research Complete
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  Data: Sleep in Infants with Down Syndrome or Familial Likelihood of Autism in the First Year of Life.
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  Data: <searchLink fieldCode="AR" term="%22Coco%2C+Emma+R%2E%22">Coco, Emma R.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Munson%2C+Jeffrey%22">Munson, Jeffrey</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22John%2C+Tanya+St%2E%22">John, Tanya St.</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dager%2C+Stephen+R%2E%22">Dager, Stephen R.</searchLink><relatesTo>1,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Botteron%2C+Kelly%22">Botteron, Kelly</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Elison%2C+Jed%22">Elison, Jed</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Garic%2C+Dea%22">Garic, Dea</searchLink><relatesTo>7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hazlett%2C+Heather%22">Hazlett, Heather</searchLink><relatesTo>7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Chimei%22">Lee, Chimei</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Marrus%2C+Natasha%22">Marrus, Natasha</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pruett+Jr%2E%2C+John+R%2E%22">Pruett Jr., John R.</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schultz%2C+Robert%22">Schultz, Robert</searchLink><relatesTo>8</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shen%2C+Mark%22">Shen, Mark</searchLink><relatesTo>7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zwaigenbaum%2C+Lonnie%22">Zwaigenbaum, Lonnie</searchLink><relatesTo>9</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Piven%2C+Joseph%22">Piven, Joseph</searchLink><relatesTo>7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Estes%2C+Annette%22">Estes, Annette</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> estesa@uw.edu</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Autism+%26+Developmental+Disorders%22">Journal of Autism & Developmental Disorders</searchLink>. Dec2025, Vol. 55 Issue 12, p4439-4449. 11p.
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  Data: *<searchLink fieldCode="DE" term="%22Down+syndrome%22">Down syndrome</searchLink><br />*<searchLink fieldCode="DE" term="%22Academic+medical+centers%22">Academic medical centers</searchLink><br />*<searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br />*<searchLink fieldCode="DE" term="%22Research%22">Research</searchLink><br />*<searchLink fieldCode="DE" term="%22Asperger's+syndrome%22">Asperger's syndrome</searchLink><br />*<searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br />*<searchLink fieldCode="DE" term="%22Children%22">Children</searchLink><br /><searchLink fieldCode="DE" term="%22Genetics+of+autism%22">Genetics of autism</searchLink><br /><searchLink fieldCode="DE" term="%22Risk+assessment%22">Risk assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Questionnaires%22">Questionnaires</searchLink><br /><searchLink fieldCode="DE" term="%22Neurological+disorders%22">Neurological disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Sleep%22">Sleep</searchLink><br /><searchLink fieldCode="DE" term="%22Sleep+disorders%22">Sleep disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Wakefulness%22">Wakefulness</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+testing%22">Genetic testing</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+risk+factors%22">Disease risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+complications%22">Disease complications</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22United+States%22">United States</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Sleep problems have been associated with atypical development, but there is limited understanding of when sleep problems arise and how they differ across clinical populations. We aimed to evaluate sleep characteristics of infants with Down syndrome (DS), higher familial likelihood of autism (HL) and lower familial likelihood of autism (LL) at 6 and 12 months of age. Participants were from two longitudinal, multi-site, studies. Sleep was estimated by parent report on the Brief Infant Sleep Questionnaire at 6 months (59 DS, 173 HL, 54 LL); 12 months (58 DS, 129 HL, 30 LL); and in a longitudinal subset at both 6 and 12 months (100 HL; 23 LL; 33 DS). At 6-months, DS parents reported less concern about infant sleep and less night wakefulness than LL parents; HL parents reported longer sleep onset latency (SOL). At 12 months DS parents reported less night sleep and more night wakefulness; HL parents reported less night sleep, more night wakefulness and longer SOL compared to LL. Night wakefulness increased significantly in the DS and HL groups from 6 to 12 months of age. A higher proportion of DS and HL infants decreased Night Sleep and increased Night Wakefulness compared with the LL group. A higher proportion of DS infants increased SOL compared with the LL group. Sleep alterations are present in the first year of life and may differ in DS and HL infants. The mechanisms behind these sleep alterations may be an important early intervention target. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Journal of Autism & Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=ehh&AN=189168320
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        Value: 10.1007/s10803-025-06927-4
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        Text: English
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      – SubjectFull: Down syndrome
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      – SubjectFull: Academic medical centers
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