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ANTIELASTASIC ACTIVITY OF ANTISTRESSANTS IN BONE TISSUE OF RATS AFTER STRESS.

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Title: ANTIELASTASIC ACTIVITY OF ANTISTRESSANTS IN BONE TISSUE OF RATS AFTER STRESS.
Authors: Pavlenko, K. V.1
Source: Journal of Education, Health & Sport. 2026, Vol. 89, p1-8. 8p.
Subject Terms: Elastases, Antioxidants, Bioflavonoids, Bone cells, Proteolytic enzymes, Oxidative stress, Rats, Psychological stress
Abstract: Background. Stress causes the development of post-stress pathological reactions, which culminate in dysmetabolic disorders, against the background of which most diseases of humans and animals develop. Bone tissue has been found to be one of the most sensitive organs and tissues to the effects of dysmetabolic syndrome. Aim. Study of the effect of stress on the activity of the proteolytic enzyme elastase in bone tissue and determination of the possibility of preventing elastase activation using antistress agents. Methods. Stress was induced in rats by holding the animals at −20 °C for 30 minutes and elastase activity was investigated on the 4th day after stress. Antioxidant preparations EkSoVit, Quercetin and ascorbic acid were used as anti-stressors, which were administered into the oral cavity 3 days before stress and 3 days after stress in the form of an oral gel in doses (mg/kg): EkSoVit 0.43 and 1.07, Quercetin 0.128 and 0.257 and ascorbic acid 0.257. Results. In rats without stress, the elastase activity in the femur was (μk-kat/kg) 6.66; in rats after stress 9.61; in rats with stress that received EkSoVit, 8.16 and 6.90; in rats with stress that received quercetin, 7.20 and 5.60; in rats with stress that received ascorbic acid, 7.20. The antielastase activity in vivo was: EkSoVit – 49.15 and 126.05; quercetin – 112.10 and 135.93 and ascorbic acid – 81.63. The antielastase efficacy of antistressants was after conversion of antielastase activity to a dose of 1 g/kg: for EkSoVit 114.3 and 117.8; for quercetin 875.8 and 528.9; for ascorbic acid 317.8. Conclusion. After stress, the activity of the proteolytic enzyme elastase increases in bone tissue. The use of anti-stress agents with antioxidant action significantly prevents the activation of elastase. The most effective anti-elastase drug was quercetin (vitamin P). [ABSTRACT FROM AUTHOR]
Copyright of Journal of Education, Health & Sport is the property of Nicolaus Copernicus University in Torun and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Education Research Complete
FullText Text:
  Availability: 0
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DbLabel: Education Research Complete
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: ANTIELASTASIC ACTIVITY OF ANTISTRESSANTS IN BONE TISSUE OF RATS AFTER STRESS.
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  Data: <searchLink fieldCode="AR" term="%22Pavlenko%2C+K%2E+V%2E%22">Pavlenko, K. V.</searchLink><relatesTo>1</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Education%2C+Health+%26+Sport%22">Journal of Education, Health & Sport</searchLink>. 2026, Vol. 89, p1-8. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Elastases%22">Elastases</searchLink><br /><searchLink fieldCode="DE" term="%22Antioxidants%22">Antioxidants</searchLink><br /><searchLink fieldCode="DE" term="%22Bioflavonoids%22">Bioflavonoids</searchLink><br /><searchLink fieldCode="DE" term="%22Bone+cells%22">Bone cells</searchLink><br /><searchLink fieldCode="DE" term="%22Proteolytic+enzymes%22">Proteolytic enzymes</searchLink><br /><searchLink fieldCode="DE" term="%22Oxidative+stress%22">Oxidative stress</searchLink><br /><searchLink fieldCode="DE" term="%22Rats%22">Rats</searchLink><br /><searchLink fieldCode="DE" term="%22Psychological+stress%22">Psychological stress</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background. Stress causes the development of post-stress pathological reactions, which culminate in dysmetabolic disorders, against the background of which most diseases of humans and animals develop. Bone tissue has been found to be one of the most sensitive organs and tissues to the effects of dysmetabolic syndrome. Aim. Study of the effect of stress on the activity of the proteolytic enzyme elastase in bone tissue and determination of the possibility of preventing elastase activation using antistress agents. Methods. Stress was induced in rats by holding the animals at −20 °C for 30 minutes and elastase activity was investigated on the 4th day after stress. Antioxidant preparations EkSoVit, Quercetin and ascorbic acid were used as anti-stressors, which were administered into the oral cavity 3 days before stress and 3 days after stress in the form of an oral gel in doses (mg/kg): EkSoVit 0.43 and 1.07, Quercetin 0.128 and 0.257 and ascorbic acid 0.257. Results. In rats without stress, the elastase activity in the femur was (μk-kat/kg) 6.66; in rats after stress 9.61; in rats with stress that received EkSoVit, 8.16 and 6.90; in rats with stress that received quercetin, 7.20 and 5.60; in rats with stress that received ascorbic acid, 7.20. The antielastase activity in vivo was: EkSoVit – 49.15 and 126.05; quercetin – 112.10 and 135.93 and ascorbic acid – 81.63. The antielastase efficacy of antistressants was after conversion of antielastase activity to a dose of 1 g/kg: for EkSoVit 114.3 and 117.8; for quercetin 875.8 and 528.9; for ascorbic acid 317.8. Conclusion. After stress, the activity of the proteolytic enzyme elastase increases in bone tissue. The use of anti-stress agents with antioxidant action significantly prevents the activation of elastase. The most effective anti-elastase drug was quercetin (vitamin P). [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Group: Ab
  Data: <i>Copyright of Journal of Education, Health & Sport is the property of Nicolaus Copernicus University in Torun and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.12775/JEHS.2026.89.70805
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      – Code: eng
        Text: English
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        PageCount: 8
        StartPage: 1
    Subjects:
      – SubjectFull: Elastases
        Type: general
      – SubjectFull: Antioxidants
        Type: general
      – SubjectFull: Bioflavonoids
        Type: general
      – SubjectFull: Bone cells
        Type: general
      – SubjectFull: Proteolytic enzymes
        Type: general
      – SubjectFull: Oxidative stress
        Type: general
      – SubjectFull: Rats
        Type: general
      – SubjectFull: Psychological stress
        Type: general
    Titles:
      – TitleFull: ANTIELASTASIC ACTIVITY OF ANTISTRESSANTS IN BONE TISSUE OF RATS AFTER STRESS.
        Type: main
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            NameFull: Pavlenko, K. V.
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              M: 02
              Text: 2026
              Type: published
              Y: 2026
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