Hyperandrogenemia and behavioural changes in a mare with equine metabolic syndrome.
Saved in:
| Title: | Hyperandrogenemia and behavioural changes in a mare with equine metabolic syndrome. |
|---|---|
| Authors: | Shell, K.1 (AUTHOR) katja.faquet@gmx.de, Rijkenhuizen, A. B. M.2 (AUTHOR), Vervuert, I.3 (AUTHOR) |
| Source: | Equine Veterinary Education. Jul2026, Vol. 38 Issue 7, pe374-e379. 6p. |
| Subject Terms: | *Behavior disorders, Metabolic syndrome, Insulin regulation, Mares, Anti-Müllerian hormone, Hyperandrogenism, Granulosa cell tumors, Thyroid cancer |
| Abstract: | Summary: Hyperandrogenemia and elevated serum anti‐Mullerian hormone (AMH), as well as an increased risk to develop cancer, are well described in women with metabolic syndrome (MS). This case report describes a mare presenting with a 1‐year history of behavioural changes making her unable to be ridden, lack of signs of oestrus, hyperandrogenemia, increased AMH concentration and an enlarged right thyroid gland. Granulosa theca cell tumour (GCT) was suspected by the referring veterinarian due to behavioural changes and inability to work under the saddle, which commonly are associated with GCT in mares. Only mild elevation of AMH levels in the serum, unremarkable findings upon ovarian palpation and ultrasonography made the diagnosis of GCT questionable. At referral in mid‐April, body condition score (BCS) of six out of nine and regional fat deposits were suggestive of equine metabolic syndrome (EMS). Insulin dysregulation (ID) was confirmed by an oral sugar test (OST). A diet considering adequate energy and nutrient intake and exercise regime improved behaviour, work under saddle and insulin levels. Furthermore, the mare showed signs of oestrus again and serum AMH and testosterone were within normal limits. Due to ultrasonographic changes of the thyroid gland, it was excised and thyroid carcinoma confirmed. This case describes the occurrence of EMS, behavioural changes, hyperandrogenemia and concurrent neoplasia in a mare. While there is no proof of a causative link between neoplasia and EMS, the observation of the concurrent pathologies is interesting and warrants further investigation. [ABSTRACT FROM AUTHOR] |
| Copyright of Equine Veterinary Education is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Education Research Complete |
| FullText | Text: Availability: 0 |
|---|---|
| Header | DbId: ehh DbLabel: Education Research Complete An: 194361971 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Hyperandrogenemia and behavioural changes in a mare with equine metabolic syndrome. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Shell%2C+K%2E%22">Shell, K.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> katja.faquet@gmx.de</i><br /><searchLink fieldCode="AR" term="%22Rijkenhuizen%2C+A%2E+B%2E+M%2E%22">Rijkenhuizen, A. B. M.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vervuert%2C+I%2E%22">Vervuert, I.</searchLink><relatesTo>3</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Equine+Veterinary+Education%22">Equine Veterinary Education</searchLink>. Jul2026, Vol. 38 Issue 7, pe374-e379. 6p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22Behavior+disorders%22">Behavior disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Metabolic+syndrome%22">Metabolic syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Insulin+regulation%22">Insulin regulation</searchLink><br /><searchLink fieldCode="DE" term="%22Mares%22">Mares</searchLink><br /><searchLink fieldCode="DE" term="%22Anti-Müllerian+hormone%22">Anti-Müllerian hormone</searchLink><br /><searchLink fieldCode="DE" term="%22Hyperandrogenism%22">Hyperandrogenism</searchLink><br /><searchLink fieldCode="DE" term="%22Granulosa+cell+tumors%22">Granulosa cell tumors</searchLink><br /><searchLink fieldCode="DE" term="%22Thyroid+cancer%22">Thyroid cancer</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Summary: Hyperandrogenemia and elevated serum anti‐Mullerian hormone (AMH), as well as an increased risk to develop cancer, are well described in women with metabolic syndrome (MS). This case report describes a mare presenting with a 1‐year history of behavioural changes making her unable to be ridden, lack of signs of oestrus, hyperandrogenemia, increased AMH concentration and an enlarged right thyroid gland. Granulosa theca cell tumour (GCT) was suspected by the referring veterinarian due to behavioural changes and inability to work under the saddle, which commonly are associated with GCT in mares. Only mild elevation of AMH levels in the serum, unremarkable findings upon ovarian palpation and ultrasonography made the diagnosis of GCT questionable. At referral in mid‐April, body condition score (BCS) of six out of nine and regional fat deposits were suggestive of equine metabolic syndrome (EMS). Insulin dysregulation (ID) was confirmed by an oral sugar test (OST). A diet considering adequate energy and nutrient intake and exercise regime improved behaviour, work under saddle and insulin levels. Furthermore, the mare showed signs of oestrus again and serum AMH and testosterone were within normal limits. Due to ultrasonographic changes of the thyroid gland, it was excised and thyroid carcinoma confirmed. This case describes the occurrence of EMS, behavioural changes, hyperandrogenemia and concurrent neoplasia in a mare. While there is no proof of a causative link between neoplasia and EMS, the observation of the concurrent pathologies is interesting and warrants further investigation. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Equine Veterinary Education is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=ehh&AN=194361971 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/eve.70048 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: e374 Subjects: – SubjectFull: Behavior disorders Type: general – SubjectFull: Metabolic syndrome Type: general – SubjectFull: Insulin regulation Type: general – SubjectFull: Mares Type: general – SubjectFull: Anti-Müllerian hormone Type: general – SubjectFull: Hyperandrogenism Type: general – SubjectFull: Granulosa cell tumors Type: general – SubjectFull: Thyroid cancer Type: general Titles: – TitleFull: Hyperandrogenemia and behavioural changes in a mare with equine metabolic syndrome. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Shell, K. – PersonEntity: Name: NameFull: Rijkenhuizen, A. B. M. – PersonEntity: Name: NameFull: Vervuert, I. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 09577734 Numbering: – Type: volume Value: 38 – Type: issue Value: 7 Titles: – TitleFull: Equine Veterinary Education Type: main |
| ResultId | 1 |
