Neural Indicators of Inhibition in Tinnitus: Onset-Offset and Sensory Gating Auditory Evoked Potentials Vary by Stimulus Frequency and Tinnitus Severity.
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| Title: | Neural Indicators of Inhibition in Tinnitus: Onset-Offset and Sensory Gating Auditory Evoked Potentials Vary by Stimulus Frequency and Tinnitus Severity. |
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| Authors: | Morse, Kenneth V.1 kenneth.morse@hsc.wvu.edu, Morse, Leah R.1 |
| Source: | Journal of Speech, Language & Hearing Research. Sep2026, Vol. 69 Issue 9, p4543-4561. 19p. |
| Subject Terms: | *Data analysis, *Neurophysiology, *Comparative studies, Auditory cortex, T-test (Statistics), Research funding, Severity of illness index, Musical perception, Descriptive statistics, Tinnitus, Case-control method, Analysis of variance, Statistics, Acoustic stimulation, Data analysis software, Auditory evoked response, Musical pitch |
| Geographic Terms: | West Virginia |
| Abstract: | Purpose: The purpose of this study was to evaluate the effect of stimulus frequency and tinnitus severity on measurements indicative of inhibition called onset-offset and sensory gating auditory evoked potentials (AEPs). The specific aims were to (a) determine the effect of stimulus frequency on AEPs in people with and without tinnitus; (b) determine if people with high-frequency tinnitus demonstrate abnormal AEPs in response to high-frequency stimuli; and (c) compare AEPs in people with tinnitus of varying severity. Method: A total of 26 people with tinnitus and 26 age-, sex-, and hearing-matched no-tinnitus controls participated. AEPs were recorded in response to stimuli of varying frequency (broadband noise [BBN], 0.25, 2, 8 kHz). AEPs were quantified by measuring difference wave amplitudes and latencies. For Aims 1 and 2, mixed-model ANOVAs were calculated to determine the main effect of and interaction between stimulus frequency and tinnitus presence. For Aim 3, participants were divided into subgroups based on median tinnitus severity and f tests were used to compare AEPs between subgroups. Results: (1) BBN evoked the largest amplitude onset-offset and sensory gating difference waves. As stimulus frequency increased, amplitude decreased. (2) Individuals who perceived high-frequency tinnitus did not demonstrate the most abnormal onset-offset and sensory gating AEPs in response to high-frequency stimuli. (3) Individuals with moderate and severe tinnitus demonstrated abnormal sensory gating AEPs compared to age-, hearing-, and sex-matched no-tinnitus controls and compared to individuals with milder tinnitus who were of similar age and hearing status. Conclusions: Stimulus frequency does influence onset-offset and sensory gating AEPs. People with moderate and severe tinnitus demonstrated reduced inhibition compared to people with milder tinnitus, indicated by abnormal sensory gating AEPs. This suggests that a person's psychological reaction to their tinnitus may be linked to unconscious physiological mechanisms underlying tinnitus, including reduced inhibition. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Speech, Language & Hearing Research is the property of American Speech-Language-Hearing Association and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Education Research Complete |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: ehh DbLabel: Education Research Complete An: 197210499 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Neural Indicators of Inhibition in Tinnitus: Onset-Offset and Sensory Gating Auditory Evoked Potentials Vary by Stimulus Frequency and Tinnitus Severity. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Morse%2C+Kenneth+V%2E%22">Morse, Kenneth V.</searchLink><relatesTo>1</relatesTo><i> kenneth.morse@hsc.wvu.edu</i><br /><searchLink fieldCode="AR" term="%22Morse%2C+Leah+R%2E%22">Morse, Leah R.</searchLink><relatesTo>1</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Speech%2C+Language+%26+Hearing+Research%22">Journal of Speech, Language & Hearing Research</searchLink>. Sep2026, Vol. 69 Issue 9, p4543-4561. 19p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22Data+analysis%22">Data analysis</searchLink><br />*<searchLink fieldCode="DE" term="%22Neurophysiology%22">Neurophysiology</searchLink><br />*<searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Auditory+cortex%22">Auditory cortex</searchLink><br /><searchLink fieldCode="DE" term="%22T-test+%28Statistics%29%22">T-test (Statistics)</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Severity+of+illness+index%22">Severity of illness index</searchLink><br /><searchLink fieldCode="DE" term="%22Musical+perception%22">Musical perception</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Tinnitus%22">Tinnitus</searchLink><br /><searchLink fieldCode="DE" term="%22Case-control+method%22">Case-control method</searchLink><br /><searchLink fieldCode="DE" term="%22Analysis+of+variance%22">Analysis of variance</searchLink><br /><searchLink fieldCode="DE" term="%22Statistics%22">Statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Acoustic+stimulation%22">Acoustic stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Auditory+evoked+response%22">Auditory evoked response</searchLink><br /><searchLink fieldCode="DE" term="%22Musical+pitch%22">Musical pitch</searchLink> – Name: SubjectGeographic Label: Geographic Terms Group: Su Data: <searchLink fieldCode="DE" term="%22West+Virginia%22">West Virginia</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: The purpose of this study was to evaluate the effect of stimulus frequency and tinnitus severity on measurements indicative of inhibition called onset-offset and sensory gating auditory evoked potentials (AEPs). The specific aims were to (a) determine the effect of stimulus frequency on AEPs in people with and without tinnitus; (b) determine if people with high-frequency tinnitus demonstrate abnormal AEPs in response to high-frequency stimuli; and (c) compare AEPs in people with tinnitus of varying severity. Method: A total of 26 people with tinnitus and 26 age-, sex-, and hearing-matched no-tinnitus controls participated. AEPs were recorded in response to stimuli of varying frequency (broadband noise [BBN], 0.25, 2, 8 kHz). AEPs were quantified by measuring difference wave amplitudes and latencies. For Aims 1 and 2, mixed-model ANOVAs were calculated to determine the main effect of and interaction between stimulus frequency and tinnitus presence. For Aim 3, participants were divided into subgroups based on median tinnitus severity and f tests were used to compare AEPs between subgroups. Results: (1) BBN evoked the largest amplitude onset-offset and sensory gating difference waves. As stimulus frequency increased, amplitude decreased. (2) Individuals who perceived high-frequency tinnitus did not demonstrate the most abnormal onset-offset and sensory gating AEPs in response to high-frequency stimuli. (3) Individuals with moderate and severe tinnitus demonstrated abnormal sensory gating AEPs compared to age-, hearing-, and sex-matched no-tinnitus controls and compared to individuals with milder tinnitus who were of similar age and hearing status. Conclusions: Stimulus frequency does influence onset-offset and sensory gating AEPs. People with moderate and severe tinnitus demonstrated reduced inhibition compared to people with milder tinnitus, indicated by abnormal sensory gating AEPs. This suggests that a person's psychological reaction to their tinnitus may be linked to unconscious physiological mechanisms underlying tinnitus, including reduced inhibition. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Speech, Language & Hearing Research is the property of American Speech-Language-Hearing Association and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1044/2026_JSLHR-25-00470 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 19 StartPage: 4543 Subjects: – SubjectFull: Data analysis Type: general – SubjectFull: Neurophysiology Type: general – SubjectFull: Comparative studies Type: general – SubjectFull: Auditory cortex Type: general – SubjectFull: T-test (Statistics) Type: general – SubjectFull: Research funding Type: general – SubjectFull: Severity of illness index Type: general – SubjectFull: Musical perception Type: general – SubjectFull: Descriptive statistics Type: general – SubjectFull: Tinnitus Type: general – SubjectFull: Case-control method Type: general – SubjectFull: Analysis of variance Type: general – SubjectFull: Statistics Type: general – SubjectFull: Acoustic stimulation Type: general – SubjectFull: Data analysis software Type: general – SubjectFull: Auditory evoked response Type: general – SubjectFull: Musical pitch Type: general – SubjectFull: West Virginia Type: general Titles: – TitleFull: Neural Indicators of Inhibition in Tinnitus: Onset-Offset and Sensory Gating Auditory Evoked Potentials Vary by Stimulus Frequency and Tinnitus Severity. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Morse, Kenneth V. – PersonEntity: Name: NameFull: Morse, Leah R. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 10924388 Numbering: – Type: volume Value: 69 – Type: issue Value: 9 Titles: – TitleFull: Journal of Speech, Language & Hearing Research Type: main |
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