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Dose Considerations and Generalization Following Script Training for Poststroke Aphasia: A Randomized Factorial Clinical Trial.

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Title: Dose Considerations and Generalization Following Script Training for Poststroke Aphasia: A Randomized Factorial Clinical Trial.
Authors: Cherney, Leora R.1,2,3 Lcherney@sralab.org, Kinsey, Laura E.1, Blaze, Erin E.1, Gray, Elizabeth L.4,5, Kwasny, Mary J.4,5, Van Vuuren, Sarel6
Source: Journal of Speech, Language & Hearing Research. Oct2026, Vol. 69 Issue 10, p4567-4586. 20p.
Subject Terms: *Chronic diseases, *Speech therapy, *Evaluation, Statistical hypothesis testing, Research funding, Rehabilitation of aphasic persons, Factorial experiment designs, Statistical sampling, Blind experiment, Treatment effectiveness, Randomized controlled trials, Descriptive statistics, Stroke rehabilitation, Stroke, Data analysis software, Stroke patients, Regression analysis, Disease complications
Geographic Terms: Illinois
Abstract: Purpose: Using script training as an intervention, this study modulated the dose parameters of stimulus repetition (i.e., long vs. short scripts) and session frequency (i.e., distributed vs. massed practice) and assessed their impact on maintenance and generalization in people with chronic poststroke aphasia. Method: The study was a single-site, factorial, single-blind randomized controlled trial. Participants were randomized in a 2 × 2 factorial design into one of four study arms, stratified by pretreatment aphasia severity: (a) distributed/short script, (b) distributed/long script, (c) massed/short script, and (d) massed/long script. Participants completed 10, 1-hr sessions of computer-based script training. Participants were assigned to one of four levels of script complexity with levels determined by aphasia severity. The primary generalization outcome measured performance on the trained script in a simulated conversation with a familiar speech-language pathologist posttreatment. Secondary outcomes included evaluating (a) maintenance of the primary outcome at 3 and 6 weeks posttreatment and (b) generalization of the trained script content to an unstructured conversation with an unfamiliar, naive partner at baseline, posttreatment, and 6 weeks posttreatment. Results: Eighty-five participants with aphasia enrolled in the study. There was no significant difference between groups from baseline to posttreatment and followup for stimulus repetition, but there was a significant difference for session frequency with massed performing better than distributed. Factor interactions over time indicated that long scripts showed greater improvements with distributed versus massed session frequency, whereas short scripts were better maintained than long scripts at 6-week follow-up. Within groups, there was significant improvement from baseline to posttreatment, which was generally maintained at 6 weeks posttreatment. Conclusions: Results provide further evidence supporting the efficacy of script training. Dose parameters such as session frequency and stimulus repetition may impact the maintenance and generalization of treatment and should be considered when delivering this and other aphasia treatments. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Speech, Language & Hearing Research is the property of American Speech-Language-Hearing Association and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Education Research Complete
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  Data: Dose Considerations and Generalization Following Script Training for Poststroke Aphasia: A Randomized Factorial Clinical Trial.
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Speech%2C+Language+%26+Hearing+Research%22">Journal of Speech, Language & Hearing Research</searchLink>. Oct2026, Vol. 69 Issue 10, p4567-4586. 20p.
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  Data: *<searchLink fieldCode="DE" term="%22Chronic+diseases%22">Chronic diseases</searchLink><br />*<searchLink fieldCode="DE" term="%22Speech+therapy%22">Speech therapy</searchLink><br />*<searchLink fieldCode="DE" term="%22Evaluation%22">Evaluation</searchLink><br /><searchLink fieldCode="DE" term="%22Statistical+hypothesis+testing%22">Statistical hypothesis testing</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Rehabilitation+of+aphasic+persons%22">Rehabilitation of aphasic persons</searchLink><br /><searchLink fieldCode="DE" term="%22Factorial+experiment+designs%22">Factorial experiment designs</searchLink><br /><searchLink fieldCode="DE" term="%22Statistical+sampling%22">Statistical sampling</searchLink><br /><searchLink fieldCode="DE" term="%22Blind+experiment%22">Blind experiment</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Randomized+controlled+trials%22">Randomized controlled trials</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Stroke+rehabilitation%22">Stroke rehabilitation</searchLink><br /><searchLink fieldCode="DE" term="%22Stroke%22">Stroke</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Stroke+patients%22">Stroke patients</searchLink><br /><searchLink fieldCode="DE" term="%22Regression+analysis%22">Regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+complications%22">Disease complications</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Illinois%22">Illinois</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Purpose: Using script training as an intervention, this study modulated the dose parameters of stimulus repetition (i.e., long vs. short scripts) and session frequency (i.e., distributed vs. massed practice) and assessed their impact on maintenance and generalization in people with chronic poststroke aphasia. Method: The study was a single-site, factorial, single-blind randomized controlled trial. Participants were randomized in a 2 × 2 factorial design into one of four study arms, stratified by pretreatment aphasia severity: (a) distributed/short script, (b) distributed/long script, (c) massed/short script, and (d) massed/long script. Participants completed 10, 1-hr sessions of computer-based script training. Participants were assigned to one of four levels of script complexity with levels determined by aphasia severity. The primary generalization outcome measured performance on the trained script in a simulated conversation with a familiar speech-language pathologist posttreatment. Secondary outcomes included evaluating (a) maintenance of the primary outcome at 3 and 6 weeks posttreatment and (b) generalization of the trained script content to an unstructured conversation with an unfamiliar, naive partner at baseline, posttreatment, and 6 weeks posttreatment. Results: Eighty-five participants with aphasia enrolled in the study. There was no significant difference between groups from baseline to posttreatment and followup for stimulus repetition, but there was a significant difference for session frequency with massed performing better than distributed. Factor interactions over time indicated that long scripts showed greater improvements with distributed versus massed session frequency, whereas short scripts were better maintained than long scripts at 6-week follow-up. Within groups, there was significant improvement from baseline to posttreatment, which was generally maintained at 6 weeks posttreatment. Conclusions: Results provide further evidence supporting the efficacy of script training. Dose parameters such as session frequency and stimulus repetition may impact the maintenance and generalization of treatment and should be considered when delivering this and other aphasia treatments. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Journal of Speech, Language & Hearing Research is the property of American Speech-Language-Hearing Association and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=ehh&AN=197829250
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        Value: 10.1044/2026_JSLHR-26-00120
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        Text: English
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      – SubjectFull: Evaluation
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      – SubjectFull: Statistical hypothesis testing
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      – SubjectFull: Stroke rehabilitation
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      – SubjectFull: Illinois
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              Text: Oct2026
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