View in EDS PDF Full Text

A Noninvasive Imaging Approach to Understanding Speech Changes Following Deep Brain Stimulation in Parkinson's Disease.

Saved in:
Bibliographic Details
Title: A Noninvasive Imaging Approach to Understanding Speech Changes Following Deep Brain Stimulation in Parkinson's Disease.
Authors: Narayana, Shalini1 narayana@uthscsa.edu, Jacks, Adam1,2, Robin, Donald A.1,3, Poizner, Howard4, Wei Zhang1, Franklin, Crystal1, Liotti, Mario5, Vogel, Deanie6, Fox, Peter T.1,7
Source: American Journal of Speech-Language Pathology. May2009, Vol. 18 Issue 2, p146-161. 16p. 2 Color Photographs, 1 Diagram, 4 Charts, 4 Graphs.
Subject Terms: *Brain stimulation, *Speech disorders, *Voice disorders, Speech, Psycholinguistics, Brain imaging, Diagnostic imaging
Abstract: Purpose: To explore the use of noninvasive functional imaging and "virtual" lesion techniques to study the neural mechanisms underlying motor speech disorders in Parkinson's disease. Here, we report the use of positron emission tomography (PET) and transcranial magnetic stimulation (TMS) to explain exacerbated speech impairment following subthalamic nucleus deep brain stimulation (STN-DBS) in a patient with Parkinson's disease. Method: Perceptual and acoustic speech measures, as well as cerebral blood flow during speech as measured by PET, were obtained with STN-DBS on and off. TMS was applied to a region in the speech motor network found to be abnormally active during DBS. Speech disruption by TMS was compared both perceptually and acoustically with speech produced with DBS on. Results: Speech production was perceptually inferior and acoustically less contrastive during left STN stimulation compared to no stimulation. Increased neural activity in left dorsal premotor cortex (PMd) was observed during DBS on. "Virtual" lesioning of this region resulted in speech characterized by decreased speech segment duration, increased pause duration, and decreased intelligibility. Conclusions: This case report provides evidence that impaired speech production accompanying STN-DBSmay result from unintended activation of PMd. Clinical application of functional imaging and TMS may lead to optimizing the delivery of STN- DBS to improve outcomes for speech production as well as general motor abilities. [ABSTRACT FROM AUTHOR]
Copyright of American Journal of Speech-Language Pathology is the property of American Speech-Language-Hearing Association and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Education Research Complete
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: ehh
DbLabel: Education Research Complete
An: 38994926
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: A Noninvasive Imaging Approach to Understanding Speech Changes Following Deep Brain Stimulation in Parkinson's Disease.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Narayana%2C+Shalini%22">Narayana, Shalini</searchLink><relatesTo>1</relatesTo><i> narayana@uthscsa.edu</i><br /><searchLink fieldCode="AR" term="%22Jacks%2C+Adam%22">Jacks, Adam</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Robin%2C+Donald+A%2E%22">Robin, Donald A.</searchLink><relatesTo>1,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Poizner%2C+Howard%22">Poizner, Howard</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Wei+Zhang%22">Wei Zhang</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Franklin%2C+Crystal%22">Franklin, Crystal</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Liotti%2C+Mario%22">Liotti, Mario</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Vogel%2C+Deanie%22">Vogel, Deanie</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Fox%2C+Peter+T%2E%22">Fox, Peter T.</searchLink><relatesTo>1,7</relatesTo>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22American+Journal+of+Speech-Language+Pathology%22">American Journal of Speech-Language Pathology</searchLink>. May2009, Vol. 18 Issue 2, p146-161. 16p. 2 Color Photographs, 1 Diagram, 4 Charts, 4 Graphs.
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: *<searchLink fieldCode="DE" term="%22Brain+stimulation%22">Brain stimulation</searchLink><br />*<searchLink fieldCode="DE" term="%22Speech+disorders%22">Speech disorders</searchLink><br />*<searchLink fieldCode="DE" term="%22Voice+disorders%22">Voice disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Speech%22">Speech</searchLink><br /><searchLink fieldCode="DE" term="%22Psycholinguistics%22">Psycholinguistics</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+imaging%22">Brain imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnostic+imaging%22">Diagnostic imaging</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: To explore the use of noninvasive functional imaging and "virtual" lesion techniques to study the neural mechanisms underlying motor speech disorders in Parkinson's disease. Here, we report the use of positron emission tomography (PET) and transcranial magnetic stimulation (TMS) to explain exacerbated speech impairment following subthalamic nucleus deep brain stimulation (STN-DBS) in a patient with Parkinson's disease. Method: Perceptual and acoustic speech measures, as well as cerebral blood flow during speech as measured by PET, were obtained with STN-DBS on and off. TMS was applied to a region in the speech motor network found to be abnormally active during DBS. Speech disruption by TMS was compared both perceptually and acoustically with speech produced with DBS on. Results: Speech production was perceptually inferior and acoustically less contrastive during left STN stimulation compared to no stimulation. Increased neural activity in left dorsal premotor cortex (PMd) was observed during DBS on. "Virtual" lesioning of this region resulted in speech characterized by decreased speech segment duration, increased pause duration, and decreased intelligibility. Conclusions: This case report provides evidence that impaired speech production accompanying STN-DBSmay result from unintended activation of PMd. Clinical application of functional imaging and TMS may lead to optimizing the delivery of STN- DBS to improve outcomes for speech production as well as general motor abilities. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of American Journal of Speech-Language Pathology is the property of American Speech-Language-Hearing Association and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=ehh&AN=38994926
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1044/1058-0360(2008/08-0004)
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 16
        StartPage: 146
    Subjects:
      – SubjectFull: Brain stimulation
        Type: general
      – SubjectFull: Speech disorders
        Type: general
      – SubjectFull: Voice disorders
        Type: general
      – SubjectFull: Speech
        Type: general
      – SubjectFull: Psycholinguistics
        Type: general
      – SubjectFull: Brain imaging
        Type: general
      – SubjectFull: Diagnostic imaging
        Type: general
    Titles:
      – TitleFull: A Noninvasive Imaging Approach to Understanding Speech Changes Following Deep Brain Stimulation in Parkinson's Disease.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Narayana, Shalini
      – PersonEntity:
          Name:
            NameFull: Jacks, Adam
      – PersonEntity:
          Name:
            NameFull: Robin, Donald A.
      – PersonEntity:
          Name:
            NameFull: Poizner, Howard
      – PersonEntity:
          Name:
            NameFull: Wei Zhang
      – PersonEntity:
          Name:
            NameFull: Franklin, Crystal
      – PersonEntity:
          Name:
            NameFull: Liotti, Mario
      – PersonEntity:
          Name:
            NameFull: Vogel, Deanie
      – PersonEntity:
          Name:
            NameFull: Fox, Peter T.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: May2009
              Type: published
              Y: 2009
          Identifiers:
            – Type: issn-print
              Value: 10580360
          Numbering:
            – Type: volume
              Value: 18
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: American Journal of Speech-Language Pathology
              Type: main
ResultId 1