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β-Blockers for Infantile Hemangiomas: A Single-Institution Experience.

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Title: β-Blockers for Infantile Hemangiomas: A Single-Institution Experience.
Authors: Blatt, Julie1, Morrell, Dean S.2, Buck, Scott2, Zdanski, Carlton2, Gold, Stuart2, Stavas, Joseph2, Powell, Cynthia2, Burkhart, Craig N.2
Source: Clinical Pediatrics. Aug2011, Vol. 50 Issue 8, p757-763. 7p.
Subject Terms: *Academic medical centers, *Children, Hemangiomas, Propranolol, Therapeutics
Geographic Terms: North Carolina
Abstract: Propranolol has become first-line therapy for the treatment of infantile hemangiomas in many centers. Of 302 children with hemangiomas seen at the University of North Carolina from 2008 through 2010, 15.6% were treated with oral propranolol alone, 5.6% with topical timolol (a propranolol derivative) alone, and 2.3% with both. The use of these agents increased over time from 7% of patients seen in 2008 to 54% of patients first seen in 2010. Starting doses of propranolol ranged from 0.25 to 1 mg/kg/d, with target doses of 1 to 4 mg/kg/d. Serious side effects, noted in 6/54 (10.9%) patients, included somnolence, bradycardia, hypotension, hypoglycemia, and mottling of extremities.The authors confirm the variation in use of propranolol for vascular lesions and extend experience with timolol. They suggest daily home monitoring of patients for the first 2 weeks of initiating or increasing doses. Frequent feeding of infants and young children on this drug is recommended. [ABSTRACT FROM PUBLISHER]
Copyright of Clinical Pediatrics is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Education Research Complete
FullText Text:
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DbLabel: Education Research Complete
An: 62249411
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
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  Data: β-Blockers for Infantile Hemangiomas: A Single-Institution Experience.
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  Data: <searchLink fieldCode="JN" term="%22Clinical+Pediatrics%22">Clinical Pediatrics</searchLink>. Aug2011, Vol. 50 Issue 8, p757-763. 7p.
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  Data: *<searchLink fieldCode="DE" term="%22Academic+medical+centers%22">Academic medical centers</searchLink><br />*<searchLink fieldCode="DE" term="%22Children%22">Children</searchLink><br /><searchLink fieldCode="DE" term="%22Hemangiomas%22">Hemangiomas</searchLink><br /><searchLink fieldCode="DE" term="%22Propranolol%22">Propranolol</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink>
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  Data: Propranolol has become first-line therapy for the treatment of infantile hemangiomas in many centers. Of 302 children with hemangiomas seen at the University of North Carolina from 2008 through 2010, 15.6% were treated with oral propranolol alone, 5.6% with topical timolol (a propranolol derivative) alone, and 2.3% with both. The use of these agents increased over time from 7% of patients seen in 2008 to 54% of patients first seen in 2010. Starting doses of propranolol ranged from 0.25 to 1 mg/kg/d, with target doses of 1 to 4 mg/kg/d. Serious side effects, noted in 6/54 (10.9%) patients, included somnolence, bradycardia, hypotension, hypoglycemia, and mottling of extremities.The authors confirm the variation in use of propranolol for vascular lesions and extend experience with timolol. They suggest daily home monitoring of patients for the first 2 weeks of initiating or increasing doses. Frequent feeding of infants and young children on this drug is recommended. [ABSTRACT FROM PUBLISHER]
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  Data: <i>Copyright of Clinical Pediatrics is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – SubjectFull: Hemangiomas
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              Text: Aug2011
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