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Effect of Acute Aerobic Exercise on Vaccine Efficacy in Older Adults.

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Title: Effect of Acute Aerobic Exercise on Vaccine Efficacy in Older Adults.
Authors: RANADIVE, SUSHANT MOHAN1,2 (AUTHOR) Ranadive.Sushant@mayo.edu, COOK, MARC1 (AUTHOR), KAPPUS, REBECCA MARIE3 (AUTHOR), HUIMIN YAN1 (AUTHOR), LANE, ABBI DANIELLE3 (AUTHOR), WOODS, JEFFERY A.1 (AUTHOR), WILUND, KENNETH R.1 (AUTHOR), IWAMOTO, GARY1 (AUTHOR), VANAR, VISHWAS1 (AUTHOR), TANDON, RUDHIR1 (AUTHOR), FERNHALL, BO1,3 (AUTHOR)
Source: Medicine & Science in Sports & Exercise. Mar2014, Vol. 46 Issue 3, p455-461. 7p. 2 Charts, 3 Graphs.
Subject Terms: *Body composition, *Statistical correlation, *Immunization, Influenza prevention, Aerobic exercises, Analysis of covariance, Analysis of variance, Blood pressure, C-reactive protein, Immunoglobulins, Influenza vaccines, Interleukins, Research funding, Randomized controlled trials, Repeated measures design, Data analysis software, Descriptive statistics
Abstract: The most effective way of avoiding influenza is through influenza vaccination. However, the vaccine is ineffective in about 25% of the older population. Immunosenescence with advancing age results in inadequate protection from disease because of ineffective responses to vaccination. Recently, a number of strategies have been tested to improve the efficacy of a vaccine in older adults. An acute bout of moderate aerobic exercise may increase the efficacy of the vaccine in young individuals, but there are limited efficacy data in older adults who would benefit most. Purpose: This study sought to evaluate whether acute moderate-intensity endurance exercise immediately before influenza vaccination would increase the efficacy of the vaccine. Methods: Fifty-nine healthy volunteers between 55 and 75 yr of age were randomly allocated to an exercise or control group. Antibody titers were measured at baseline before exercise and 4 wk after vaccination. C-reactive protein (CRP) and interleukin-6 (IL-6) were measured at 24 and 48 h after vaccination. Results: Delta CRP and IL-6 at 24 and 48 h were significantly higher after vaccination as compared to the sham injection. There were no differences in the levels of antibody titers against the H3N2 influenza strain between groups. However, women in the exercise group had a significantly higher antibody response against the H1N1 influenza strain as compared to the men, probably because of lower prevaccine titers. There were no significant differences in seroprotection between groups. Conclusions: Acute moderate aerobic exercise was not immunostimulatory in healthy older men but may serve as a vaccine adjuvant in older women. [ABSTRACT FROM AUTHOR]
Copyright of Medicine & Science in Sports & Exercise is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Effect of Acute Aerobic Exercise on Vaccine Efficacy in Older Adults.
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  Data: <searchLink fieldCode="AR" term="%22RANADIVE%2C+SUSHANT+MOHAN%22">RANADIVE, SUSHANT MOHAN</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> Ranadive.Sushant@mayo.edu</i><br /><searchLink fieldCode="AR" term="%22COOK%2C+MARC%22">COOK, MARC</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22KAPPUS%2C+REBECCA+MARIE%22">KAPPUS, REBECCA MARIE</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22HUIMIN+YAN%22">HUIMIN YAN</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22LANE%2C+ABBI+DANIELLE%22">LANE, ABBI DANIELLE</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22WOODS%2C+JEFFERY+A%2E%22">WOODS, JEFFERY A.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22WILUND%2C+KENNETH+R%2E%22">WILUND, KENNETH R.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22IWAMOTO%2C+GARY%22">IWAMOTO, GARY</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22VANAR%2C+VISHWAS%22">VANAR, VISHWAS</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22TANDON%2C+RUDHIR%22">TANDON, RUDHIR</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22FERNHALL%2C+BO%22">FERNHALL, BO</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Medicine+%26+Science+in+Sports+%26+Exercise%22">Medicine & Science in Sports & Exercise</searchLink>. Mar2014, Vol. 46 Issue 3, p455-461. 7p. 2 Charts, 3 Graphs.
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  Data: *<searchLink fieldCode="DE" term="%22Body+composition%22">Body composition</searchLink><br />*<searchLink fieldCode="DE" term="%22Statistical+correlation%22">Statistical correlation</searchLink><br />*<searchLink fieldCode="DE" term="%22Immunization%22">Immunization</searchLink><br /><searchLink fieldCode="DE" term="%22Influenza+prevention%22">Influenza prevention</searchLink><br /><searchLink fieldCode="DE" term="%22Aerobic+exercises%22">Aerobic exercises</searchLink><br /><searchLink fieldCode="DE" term="%22Analysis+of+covariance%22">Analysis of covariance</searchLink><br /><searchLink fieldCode="DE" term="%22Analysis+of+variance%22">Analysis of variance</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+pressure%22">Blood pressure</searchLink><br /><searchLink fieldCode="DE" term="%22C-reactive+protein%22">C-reactive protein</searchLink><br /><searchLink fieldCode="DE" term="%22Immunoglobulins%22">Immunoglobulins</searchLink><br /><searchLink fieldCode="DE" term="%22Influenza+vaccines%22">Influenza vaccines</searchLink><br /><searchLink fieldCode="DE" term="%22Interleukins%22">Interleukins</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Randomized+controlled+trials%22">Randomized controlled trials</searchLink><br /><searchLink fieldCode="DE" term="%22Repeated+measures+design%22">Repeated measures design</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The most effective way of avoiding influenza is through influenza vaccination. However, the vaccine is ineffective in about 25% of the older population. Immunosenescence with advancing age results in inadequate protection from disease because of ineffective responses to vaccination. Recently, a number of strategies have been tested to improve the efficacy of a vaccine in older adults. An acute bout of moderate aerobic exercise may increase the efficacy of the vaccine in young individuals, but there are limited efficacy data in older adults who would benefit most. Purpose: This study sought to evaluate whether acute moderate-intensity endurance exercise immediately before influenza vaccination would increase the efficacy of the vaccine. Methods: Fifty-nine healthy volunteers between 55 and 75 yr of age were randomly allocated to an exercise or control group. Antibody titers were measured at baseline before exercise and 4 wk after vaccination. C-reactive protein (CRP) and interleukin-6 (IL-6) were measured at 24 and 48 h after vaccination. Results: Delta CRP and IL-6 at 24 and 48 h were significantly higher after vaccination as compared to the sham injection. There were no differences in the levels of antibody titers against the H3N2 influenza strain between groups. However, women in the exercise group had a significantly higher antibody response against the H1N1 influenza strain as compared to the men, probably because of lower prevaccine titers. There were no significant differences in seroprotection between groups. Conclusions: Acute moderate aerobic exercise was not immunostimulatory in healthy older men but may serve as a vaccine adjuvant in older women. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Medicine & Science in Sports & Exercise is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1249/MSS.0b013e3182a75ff2
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      – Code: eng
        Text: English
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        StartPage: 455
    Subjects:
      – SubjectFull: Body composition
        Type: general
      – SubjectFull: Statistical correlation
        Type: general
      – SubjectFull: Immunization
        Type: general
      – SubjectFull: Influenza prevention
        Type: general
      – SubjectFull: Aerobic exercises
        Type: general
      – SubjectFull: Analysis of covariance
        Type: general
      – SubjectFull: Analysis of variance
        Type: general
      – SubjectFull: Blood pressure
        Type: general
      – SubjectFull: C-reactive protein
        Type: general
      – SubjectFull: Immunoglobulins
        Type: general
      – SubjectFull: Influenza vaccines
        Type: general
      – SubjectFull: Interleukins
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Randomized controlled trials
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      – SubjectFull: Repeated measures design
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      – SubjectFull: Descriptive statistics
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      – TitleFull: Effect of Acute Aerobic Exercise on Vaccine Efficacy in Older Adults.
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              Text: Mar2014
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