Endogenous anandamide and self-reported pain are significantly reduced after a 2-week multimodal treatment with and without radon therapy in patients with knee osteoarthritis: a pilot study.
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| Title: | Endogenous anandamide and self-reported pain are significantly reduced after a 2-week multimodal treatment with and without radon therapy in patients with knee osteoarthritis: a pilot study. |
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| Authors: | Gaisberger, M.1,2,3 (AUTHOR) martin.gaisberger@pmu.ac.at, Fuchs, J.1,2 (AUTHOR), Riedl, M.4 (AUTHOR), Edtinger, S.5 (AUTHOR), Reischl, R.6 (AUTHOR), Grasmann, G.6 (AUTHOR), Hölzl, B.7 (AUTHOR), Landauer, F.4 (AUTHOR), Dobias, H.1,2 (AUTHOR), Eckstein, F.3,8,9 (AUTHOR), Offenbächer, M.10 (AUTHOR), Ritter, M.1,2,3 (AUTHOR), Winklmayr, M.1,3 (AUTHOR) |
| Source: | International Journal of Biometeorology. Jul2021, Vol. 65 Issue 7, p1151-1160. 10p. |
| Subject Terms: | *Knee, *Radon, *Anandamide, *Combined modality therapy, *Pilot projects, *Knee osteoarthritis, *Self-efficacy |
| Geographic Terms: | Tripoli (Libya) |
| Abstract: | Multimodal therapies comprising spa applications are widely used as non-pharmaceutical treatment options for musculoskeletal diseases. The purpose of this randomized, controlled, open pilot study was to elucidate the involvement of the endocannabinoid system in a multimodal therapy approach. Twenty-five elderly patients with knee osteoarthritis (OA) received a 2-week spa therapy with or without combination of low-dose radon therapy in the Bad Gastein radon gallery. A 10-point numerical rating scale (pain in motion and at rest), WOMAC questionnaire, and the EuroQol-5D (EQ-5D) questionnaire were recorded at baseline, and during treatment period at weeks one and two, and at 3-month and 6-month follow-ups. Plasma levels of the endocannabinoid anandamide (AEA) were determined at baseline and at 2 weeks, and serum levels of several cartilage metabolism markers at all five time-points. A significant and sustained reduction of self-reported knee pain was observed in the study population, but no further significant effect of the additional radon therapy up and above base therapy. This pain reduction was accompanied by a significant reduction of AEA plasma levels during treatment in both groups. No significant differences were seen in serum marker concentrations between the groups treated with or without radon, but a small reduction of serum cartilage degradation markers was observed during treatment in both groups. This is the first study investigating AEA levels in the context of a non-pharmacological OA treatment. Since the endocannabinoid system represents a potential target for the development of new therapeutics, further studies will have to elucidate its involvement in OA pain. [ABSTRACT FROM AUTHOR] |
| Database: | Energy & Power Source |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: enr DbLabel: Energy & Power Source An: 150974562 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Endogenous anandamide and self-reported pain are significantly reduced after a 2-week multimodal treatment with and without radon therapy in patients with knee osteoarthritis: a pilot study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Gaisberger%2C+M%2E%22">Gaisberger, M.</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<i> martin.gaisberger@pmu.ac.at</i><br /><searchLink fieldCode="AR" term="%22Fuchs%2C+J%2E%22">Fuchs, J.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Riedl%2C+M%2E%22">Riedl, M.</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Edtinger%2C+S%2E%22">Edtinger, S.</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Reischl%2C+R%2E%22">Reischl, R.</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Grasmann%2C+G%2E%22">Grasmann, G.</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hölzl%2C+B%2E%22">Hölzl, B.</searchLink><relatesTo>7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Landauer%2C+F%2E%22">Landauer, F.</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dobias%2C+H%2E%22">Dobias, H.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Eckstein%2C+F%2E%22">Eckstein, F.</searchLink><relatesTo>3,8,9</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Offenbächer%2C+M%2E%22">Offenbächer, M.</searchLink><relatesTo>10</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ritter%2C+M%2E%22">Ritter, M.</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Winklmayr%2C+M%2E%22">Winklmayr, M.</searchLink><relatesTo>1,3</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Biometeorology%22">International Journal of Biometeorology</searchLink>. Jul2021, Vol. 65 Issue 7, p1151-1160. 10p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22Knee%22">Knee</searchLink><br />*<searchLink fieldCode="DE" term="%22Radon%22">Radon</searchLink><br />*<searchLink fieldCode="DE" term="%22Anandamide%22">Anandamide</searchLink><br />*<searchLink fieldCode="DE" term="%22Combined+modality+therapy%22">Combined modality therapy</searchLink><br />*<searchLink fieldCode="DE" term="%22Pilot+projects%22">Pilot projects</searchLink><br />*<searchLink fieldCode="DE" term="%22Knee+osteoarthritis%22">Knee osteoarthritis</searchLink><br />*<searchLink fieldCode="DE" term="%22Self-efficacy%22">Self-efficacy</searchLink> – Name: SubjectGeographic Label: Geographic Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Tripoli+%28Libya%29%22">Tripoli (Libya)</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Multimodal therapies comprising spa applications are widely used as non-pharmaceutical treatment options for musculoskeletal diseases. The purpose of this randomized, controlled, open pilot study was to elucidate the involvement of the endocannabinoid system in a multimodal therapy approach. Twenty-five elderly patients with knee osteoarthritis (OA) received a 2-week spa therapy with or without combination of low-dose radon therapy in the Bad Gastein radon gallery. A 10-point numerical rating scale (pain in motion and at rest), WOMAC questionnaire, and the EuroQol-5D (EQ-5D) questionnaire were recorded at baseline, and during treatment period at weeks one and two, and at 3-month and 6-month follow-ups. Plasma levels of the endocannabinoid anandamide (AEA) were determined at baseline and at 2 weeks, and serum levels of several cartilage metabolism markers at all five time-points. A significant and sustained reduction of self-reported knee pain was observed in the study population, but no further significant effect of the additional radon therapy up and above base therapy. This pain reduction was accompanied by a significant reduction of AEA plasma levels during treatment in both groups. No significant differences were seen in serum marker concentrations between the groups treated with or without radon, but a small reduction of serum cartilage degradation markers was observed during treatment in both groups. This is the first study investigating AEA levels in the context of a non-pharmacological OA treatment. Since the endocannabinoid system represents a potential target for the development of new therapeutics, further studies will have to elucidate its involvement in OA pain. [ABSTRACT FROM AUTHOR] |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00484-021-02095-z Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 1151 Subjects: – SubjectFull: Knee Type: general – SubjectFull: Radon Type: general – SubjectFull: Anandamide Type: general – SubjectFull: Combined modality therapy Type: general – SubjectFull: Pilot projects Type: general – SubjectFull: Knee osteoarthritis Type: general – SubjectFull: Self-efficacy Type: general – SubjectFull: Tripoli (Libya) Type: general Titles: – TitleFull: Endogenous anandamide and self-reported pain are significantly reduced after a 2-week multimodal treatment with and without radon therapy in patients with knee osteoarthritis: a pilot study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Gaisberger, M. – PersonEntity: Name: NameFull: Fuchs, J. – PersonEntity: Name: NameFull: Riedl, M. – PersonEntity: Name: NameFull: Edtinger, S. – PersonEntity: Name: NameFull: Reischl, R. – PersonEntity: Name: NameFull: Grasmann, G. – PersonEntity: Name: NameFull: Hölzl, B. – PersonEntity: Name: NameFull: Landauer, F. – PersonEntity: Name: NameFull: Dobias, H. – PersonEntity: Name: NameFull: Eckstein, F. – PersonEntity: Name: NameFull: Offenbächer, M. – PersonEntity: Name: NameFull: Ritter, M. – PersonEntity: Name: NameFull: Winklmayr, M. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2021 Type: published Y: 2021 Identifiers: – Type: issn-print Value: 00207128 Numbering: – Type: volume Value: 65 – Type: issue Value: 7 Titles: – TitleFull: International Journal of Biometeorology Type: main |
| ResultId | 1 |
