Association of transient mitochondrial functional impairment with acute heat exposure in children from Muzaffarpur region of Bihar, India.
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| Title: | Association of transient mitochondrial functional impairment with acute heat exposure in children from Muzaffarpur region of Bihar, India. |
|---|---|
| Authors: | Singh, Kanika1 (AUTHOR), Kumari, Swati1,2 (AUTHOR), Ali, Manzoor1,2 (AUTHOR), Das, Manoja K.3 (AUTHOR), Mishra, Aastha1,2 (AUTHOR) aastha.mishra@igib.res.in, Singh, Arun K.4 (AUTHOR) drarunsingh61@yahoo.co.in |
| Source: | International Journal of Biometeorology. Dec2023, Vol. 67 Issue 12, p1975-1989. 15p. |
| Subject Terms: | *Mononuclear leukocytes, *Mitochondria, *Viral encephalitis |
| Geographic Terms: | Bihar (India) |
| Abstract: | Over the past several years, the Muzaffarpur district of Bihar (India) has witnessed recurrent outbreaks of acute encephalitis illness of unknown etiology, called acute encephalitis syndrome (AES) among young children, especially during the peak-summer season. Pesticide exposure, viral encephalitis, and litchi toxin intake have all been postulated as potential sources of the ailment. However, no conclusive etiology for AES has been identified in the affected children. During recent rounds of the outbreak, metabolic abnormalities have been documented in these children, and a direct correlation was observed between higher environmental temperature during the peak-summer month and AES caseload. The clinical and metabolic profiles of these children suggested the possible involvement of mitochondrial dysfunction during heat stress as one of the several contributory factors leading to multisystem metabolic derangement. The present study observed that mitochondrial function parameters such as cell death, mitochondrial membrane potential, oxidative stress, and mitochondrial pathway-related gene expression in peripheral blood mononuclear cells (PBMCs) isolated from children were affected in peak-summer when compared to post-summer months. Similar observations of mitochondrial function parameters along with impaired bioenergetic parameters were demonstrated in the heat-exposed model of PBMCs isolated from healthy adult individuals. In conclusion, the results suggested that there is an association of transient mitochondrial dysfunction when exposed to sustained heat during the summer months. One may consider mitochondrial dysfunction as one of the important factors leading to an outbreak of AES among the children from affected regions though this needs to be substantiated with further studies. [ABSTRACT FROM AUTHOR] |
| Database: | Energy & Power Source |
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| Header | DbId: enr DbLabel: Energy & Power Source An: 173585557 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Association of transient mitochondrial functional impairment with acute heat exposure in children from Muzaffarpur region of Bihar, India. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Singh%2C+Kanika%22">Singh, Kanika</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kumari%2C+Swati%22">Kumari, Swati</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ali%2C+Manzoor%22">Ali, Manzoor</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Das%2C+Manoja+K%2E%22">Das, Manoja K.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mishra%2C+Aastha%22">Mishra, Aastha</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> aastha.mishra@igib.res.in</i><br /><searchLink fieldCode="AR" term="%22Singh%2C+Arun+K%2E%22">Singh, Arun K.</searchLink><relatesTo>4</relatesTo> (AUTHOR)<i> drarunsingh61@yahoo.co.in</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Biometeorology%22">International Journal of Biometeorology</searchLink>. Dec2023, Vol. 67 Issue 12, p1975-1989. 15p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22Mononuclear+leukocytes%22">Mononuclear leukocytes</searchLink><br />*<searchLink fieldCode="DE" term="%22Mitochondria%22">Mitochondria</searchLink><br />*<searchLink fieldCode="DE" term="%22Viral+encephalitis%22">Viral encephalitis</searchLink> – Name: SubjectGeographic Label: Geographic Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Bihar+%28India%29%22">Bihar (India)</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Over the past several years, the Muzaffarpur district of Bihar (India) has witnessed recurrent outbreaks of acute encephalitis illness of unknown etiology, called acute encephalitis syndrome (AES) among young children, especially during the peak-summer season. Pesticide exposure, viral encephalitis, and litchi toxin intake have all been postulated as potential sources of the ailment. However, no conclusive etiology for AES has been identified in the affected children. During recent rounds of the outbreak, metabolic abnormalities have been documented in these children, and a direct correlation was observed between higher environmental temperature during the peak-summer month and AES caseload. The clinical and metabolic profiles of these children suggested the possible involvement of mitochondrial dysfunction during heat stress as one of the several contributory factors leading to multisystem metabolic derangement. The present study observed that mitochondrial function parameters such as cell death, mitochondrial membrane potential, oxidative stress, and mitochondrial pathway-related gene expression in peripheral blood mononuclear cells (PBMCs) isolated from children were affected in peak-summer when compared to post-summer months. Similar observations of mitochondrial function parameters along with impaired bioenergetic parameters were demonstrated in the heat-exposed model of PBMCs isolated from healthy adult individuals. In conclusion, the results suggested that there is an association of transient mitochondrial dysfunction when exposed to sustained heat during the summer months. One may consider mitochondrial dysfunction as one of the important factors leading to an outbreak of AES among the children from affected regions though this needs to be substantiated with further studies. [ABSTRACT FROM AUTHOR] |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=enr&AN=173585557 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00484-023-02555-8 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 15 StartPage: 1975 Subjects: – SubjectFull: Mononuclear leukocytes Type: general – SubjectFull: Mitochondria Type: general – SubjectFull: Viral encephalitis Type: general – SubjectFull: Bihar (India) Type: general Titles: – TitleFull: Association of transient mitochondrial functional impairment with acute heat exposure in children from Muzaffarpur region of Bihar, India. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Singh, Kanika – PersonEntity: Name: NameFull: Kumari, Swati – PersonEntity: Name: NameFull: Ali, Manzoor – PersonEntity: Name: NameFull: Das, Manoja K. – PersonEntity: Name: NameFull: Mishra, Aastha – PersonEntity: Name: NameFull: Singh, Arun K. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2023 Type: published Y: 2023 Identifiers: – Type: issn-print Value: 00207128 Numbering: – Type: volume Value: 67 – Type: issue Value: 12 Titles: – TitleFull: International Journal of Biometeorology Type: main |
| ResultId | 1 |
