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Contrasting toxicity response to a mixture of azithromycin and ivermectin between a freshwater and a euryhaline rotifer.

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Title: Contrasting toxicity response to a mixture of azithromycin and ivermectin between a freshwater and a euryhaline rotifer.
Authors: Arreguin-Rebolledo, Uriel1,2 (AUTHOR), Morales-Romero, Levi Asher1 (AUTHOR), Arzate-Cárdenas, Mario Alberto3 (AUTHOR), Páez-Osuna, Federico2 (AUTHOR), Betancourt-Lozano, Miguel4 (AUTHOR), Rico-Martínez, Roberto1 (AUTHOR) rrico@correo.uaa.mx
Source: Environmental Science & Pollution Research. Aug2024, Vol. 31 Issue 37, p49905-49915. 11p.
Subject Terms: *Emerging contaminants, *Azidothymidine, *Ivermectin, *Pharmacodynamics, *Fresh water
Abstract: Organisms are usually exposed to mixtures of emerging pollutants in aquatic environments. Due to their widespread use and environmental relevance, the individual and combined effects of the drugs azithromycin (AZT) and ivermectin (IVM) on the freshwater rotifer Lecane papuana and the euryhaline rotifer Proales similis were investigated. Rotifers showed greater sensitivity to IVM compared to AZT. The LC50 values of IVM and AZT for L. papuana and P. similis were 0.163 and 0.172 mg/L, and 13.52 and 20.00 mg/L, respectively. Population growth rates, assessed in chronic toxicity assays, responded negatively to increasing concentrations of both toxicants, either individually or in combination. Our results revealed two distinct combined toxicity responses: a strong synergistic effect in the freshwater rotifer and a marked antagonistic impact of the AZT-IVM mixtures in the euryhaline rotifer. [ABSTRACT FROM AUTHOR]
Database: Energy & Power Source
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DbLabel: Energy & Power Source
An: 179038843
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  Data: Contrasting toxicity response to a mixture of azithromycin and ivermectin between a freshwater and a euryhaline rotifer.
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  Data: <searchLink fieldCode="AR" term="%22Arreguin-Rebolledo%2C+Uriel%22">Arreguin-Rebolledo, Uriel</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Morales-Romero%2C+Levi+Asher%22">Morales-Romero, Levi Asher</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Arzate-Cárdenas%2C+Mario+Alberto%22">Arzate-Cárdenas, Mario Alberto</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Páez-Osuna%2C+Federico%22">Páez-Osuna, Federico</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Betancourt-Lozano%2C+Miguel%22">Betancourt-Lozano, Miguel</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rico-Martínez%2C+Roberto%22">Rico-Martínez, Roberto</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> rrico@correo.uaa.mx</i>
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  Data: <searchLink fieldCode="JN" term="%22Environmental+Science+%26+Pollution+Research%22">Environmental Science & Pollution Research</searchLink>. Aug2024, Vol. 31 Issue 37, p49905-49915. 11p.
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: *<searchLink fieldCode="DE" term="%22Emerging+contaminants%22">Emerging contaminants</searchLink><br />*<searchLink fieldCode="DE" term="%22Azidothymidine%22">Azidothymidine</searchLink><br />*<searchLink fieldCode="DE" term="%22Ivermectin%22">Ivermectin</searchLink><br />*<searchLink fieldCode="DE" term="%22Pharmacodynamics%22">Pharmacodynamics</searchLink><br />*<searchLink fieldCode="DE" term="%22Fresh+water%22">Fresh water</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Organisms are usually exposed to mixtures of emerging pollutants in aquatic environments. Due to their widespread use and environmental relevance, the individual and combined effects of the drugs azithromycin (AZT) and ivermectin (IVM) on the freshwater rotifer Lecane papuana and the euryhaline rotifer Proales similis were investigated. Rotifers showed greater sensitivity to IVM compared to AZT. The LC50 values of IVM and AZT for L. papuana and P. similis were 0.163 and 0.172 mg/L, and 13.52 and 20.00 mg/L, respectively. Population growth rates, assessed in chronic toxicity assays, responded negatively to increasing concentrations of both toxicants, either individually or in combination. Our results revealed two distinct combined toxicity responses: a strong synergistic effect in the freshwater rotifer and a marked antagonistic impact of the AZT-IVM mixtures in the euryhaline rotifer. [ABSTRACT FROM AUTHOR]
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=enr&AN=179038843
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        Value: 10.1007/s11356-024-34406-3
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        Text: English
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        Type: general
      – SubjectFull: Azidothymidine
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      – SubjectFull: Ivermectin
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      – SubjectFull: Pharmacodynamics
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      – SubjectFull: Fresh water
        Type: general
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            NameFull: Morales-Romero, Levi Asher
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            NameFull: Arzate-Cárdenas, Mario Alberto
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            NameFull: Betancourt-Lozano, Miguel
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            – D: 06
              M: 08
              Text: Aug2024
              Type: published
              Y: 2024
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              Value: 31
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              Value: 37
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