Bioconcentration and toxicity of perfluoroalkyl substances (PFAS) in embryonic stages of the ecologically and commercially relevant Olive Flounder (Paralichthys olivaceus), and the zebrafish (Danio rerio) embryo model system.
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| Title: | Bioconcentration and toxicity of perfluoroalkyl substances (PFAS) in embryonic stages of the ecologically and commercially relevant Olive Flounder (Paralichthys olivaceus), and the zebrafish (Danio rerio) embryo model system. |
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| Authors: | Gebreab, Kiflom1 (AUTHOR), Lawson, Ariel1 (AUTHOR), Garcia, Giancarlos1 (AUTHOR), Fox, Jessica1 (AUTHOR), Benetti, Daniel2 (AUTHOR), Stieglitz, John D.2 (AUTHOR), Quinete, Natalia Soares1,3 (AUTHOR), Berry, John P.1,3 (AUTHOR) berryj@fiu.edu |
| Source: | Ecotoxicology. Aug2025, Vol. 34 Issue 6, p973-987. 15p. |
| Subject Terms: | *Bioconcentration, *Laboratory zebrafish, *Flatfishes, *Fluoroalkyl compounds, *Embryology, *Aquatic ecology, *Poisons |
| Abstract: | Polyfluoroalkyl substances (PFAS) are ubiquitous in aquatic habitats, and there are emerging concerns that these chemicals may pose risks to organisms in these ecosystems. The present study investigated bioconcentration and toxicity of PFAS including the "legacy" congener, perfluorooctanoic acid (PFOA), and seven long- and short-chain perfluoroether carboxylic acids (PFECA) in embryonic stages of both zebrafish (Danio rerio), as an established laboratory model, and Olive Flounder (Paralichthys olivaceus), as a relevant marine fish species. Bioconcentration factors were determined for both species with BCF values ranging from 22 to 1741 L kg−1. At high exposure concentrations (i.e., 1 mg L−1), BCF values were significantly higher for zebrafish compared to flounder. Notably, however, PFAS were also measured in untreated media used for both species, and at these lower concentrations (0.2 to 29 ng L−1 and 0.4 to 9 ng L−1, respectively) approaching environmentally relevant levels, calculated BCF values were significantly higher for flounder (215–1741 L kg−1) compared to zebrafish (120–327 L kg−1) embryos. At low exposure concentration (i.e., 1 µg L−1), as well as in exposure to control media, BCF values were significantly correlated with chain length and octanol/water partition coefficients (i.e., log KOW), suggesting a role of relative lipophilicity in uptake in both species. Median lethal concentrations (LC50), and corresponding critical body residues (CBR), in the zebrafish embryo model, ranged from 0.05 to 50 mg L−1, and 0.005 to 25 µmol g−1, respectively, and significantly correlated with PFAS chain length. However, while acute toxicity for PFOA was similar between zebrafish and flounder (20 and 21 mg L−1, respectively), no significant acute toxicity was observed for flounder embryos, over the same concentration range, and corresponding CBR values were, thus, significantly higher, for all PFECA. These findings suggest differences in both uptake and relative toxicity of PFAS in these two species. Phylogenetic differences with respect to molecular targets, as well as physicochemical factors (i.e., freshwater versus saltwater), in relation to uptake and toxicity, are discussed. [ABSTRACT FROM AUTHOR] |
| Database: | Energy & Power Source |
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| Header | DbId: enr DbLabel: Energy & Power Source An: 187141781 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Bioconcentration and toxicity of perfluoroalkyl substances (PFAS) in embryonic stages of the ecologically and commercially relevant Olive Flounder (Paralichthys olivaceus), and the zebrafish (Danio rerio) embryo model system. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Gebreab%2C+Kiflom%22">Gebreab, Kiflom</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lawson%2C+Ariel%22">Lawson, Ariel</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Garcia%2C+Giancarlos%22">Garcia, Giancarlos</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fox%2C+Jessica%22">Fox, Jessica</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Benetti%2C+Daniel%22">Benetti, Daniel</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Stieglitz%2C+John+D%2E%22">Stieglitz, John D.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Quinete%2C+Natalia+Soares%22">Quinete, Natalia Soares</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Berry%2C+John+P%2E%22">Berry, John P.</searchLink><relatesTo>1,3</relatesTo> (AUTHOR)<i> berryj@fiu.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Ecotoxicology%22">Ecotoxicology</searchLink>. Aug2025, Vol. 34 Issue 6, p973-987. 15p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22Bioconcentration%22">Bioconcentration</searchLink><br />*<searchLink fieldCode="DE" term="%22Laboratory+zebrafish%22">Laboratory zebrafish</searchLink><br />*<searchLink fieldCode="DE" term="%22Flatfishes%22">Flatfishes</searchLink><br />*<searchLink fieldCode="DE" term="%22Fluoroalkyl+compounds%22">Fluoroalkyl compounds</searchLink><br />*<searchLink fieldCode="DE" term="%22Embryology%22">Embryology</searchLink><br />*<searchLink fieldCode="DE" term="%22Aquatic+ecology%22">Aquatic ecology</searchLink><br />*<searchLink fieldCode="DE" term="%22Poisons%22">Poisons</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Polyfluoroalkyl substances (PFAS) are ubiquitous in aquatic habitats, and there are emerging concerns that these chemicals may pose risks to organisms in these ecosystems. The present study investigated bioconcentration and toxicity of PFAS including the "legacy" congener, perfluorooctanoic acid (PFOA), and seven long- and short-chain perfluoroether carboxylic acids (PFECA) in embryonic stages of both zebrafish (Danio rerio), as an established laboratory model, and Olive Flounder (Paralichthys olivaceus), as a relevant marine fish species. Bioconcentration factors were determined for both species with BCF values ranging from 22 to 1741 L kg−1. At high exposure concentrations (i.e., 1 mg L−1), BCF values were significantly higher for zebrafish compared to flounder. Notably, however, PFAS were also measured in untreated media used for both species, and at these lower concentrations (0.2 to 29 ng L−1 and 0.4 to 9 ng L−1, respectively) approaching environmentally relevant levels, calculated BCF values were significantly higher for flounder (215–1741 L kg−1) compared to zebrafish (120–327 L kg−1) embryos. At low exposure concentration (i.e., 1 µg L−1), as well as in exposure to control media, BCF values were significantly correlated with chain length and octanol/water partition coefficients (i.e., log KOW), suggesting a role of relative lipophilicity in uptake in both species. Median lethal concentrations (LC50), and corresponding critical body residues (CBR), in the zebrafish embryo model, ranged from 0.05 to 50 mg L−1, and 0.005 to 25 µmol g−1, respectively, and significantly correlated with PFAS chain length. However, while acute toxicity for PFOA was similar between zebrafish and flounder (20 and 21 mg L−1, respectively), no significant acute toxicity was observed for flounder embryos, over the same concentration range, and corresponding CBR values were, thus, significantly higher, for all PFECA. These findings suggest differences in both uptake and relative toxicity of PFAS in these two species. Phylogenetic differences with respect to molecular targets, as well as physicochemical factors (i.e., freshwater versus saltwater), in relation to uptake and toxicity, are discussed. [ABSTRACT FROM AUTHOR] |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=enr&AN=187141781 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10646-025-02891-y Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 15 StartPage: 973 Subjects: – SubjectFull: Bioconcentration Type: general – SubjectFull: Laboratory zebrafish Type: general – SubjectFull: Flatfishes Type: general – SubjectFull: Fluoroalkyl compounds Type: general – SubjectFull: Embryology Type: general – SubjectFull: Aquatic ecology Type: general – SubjectFull: Poisons Type: general Titles: – TitleFull: Bioconcentration and toxicity of perfluoroalkyl substances (PFAS) in embryonic stages of the ecologically and commercially relevant Olive Flounder (Paralichthys olivaceus), and the zebrafish (Danio rerio) embryo model system. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Gebreab, Kiflom – PersonEntity: Name: NameFull: Lawson, Ariel – PersonEntity: Name: NameFull: Garcia, Giancarlos – PersonEntity: Name: NameFull: Fox, Jessica – PersonEntity: Name: NameFull: Benetti, Daniel – PersonEntity: Name: NameFull: Stieglitz, John D. – PersonEntity: Name: NameFull: Quinete, Natalia Soares – PersonEntity: Name: NameFull: Berry, John P. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 09639292 Numbering: – Type: volume Value: 34 – Type: issue Value: 6 Titles: – TitleFull: Ecotoxicology Type: main |
| ResultId | 1 |
