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Formulation of Surface-Modified Quercetin-Loaded Chitosan-Hyaluronic Acid Nanoparticles for Targeted Hepatic Cancer Therapy.

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Title: Formulation of Surface-Modified Quercetin-Loaded Chitosan-Hyaluronic Acid Nanoparticles for Targeted Hepatic Cancer Therapy.
Authors: Sahdev, Anil Kumar1 (AUTHOR), Sana, Siva Sankar2 (AUTHOR), Gupta, Priya1 (AUTHOR), Chandrakanta1 (AUTHOR), Saadaoui, S.3 (AUTHOR), Raorane, Chaitany Jayprakash2 (AUTHOR) chaitanyaraorane22@ynu.ac.kr, Kim, Seong-Cheol2 (AUTHOR), Singh, Anita1 (AUTHOR) dranitaku@gmail.com
Source: Journal of Polymers & the Environment. Jan2026, Vol. 34 Issue 1, p1-15. 15p.
Abstract: Hepatic cancer remains one of the most difficult conditions to cure, particularly when it comes to detecting and eliminating malignant metastases. To overcome hepatic cancer, various strategies have been implemented in respect to targetability and safety concern. In this study, the anticancer agent quercetin (QU) was effectively encapsulated with biocompatible polymer chitosan (CS)-hyaluronic acid (HA) to improve its poor water solubility as well as dual targetability. The resulting QU-loaded nanoparticles (QU-NPs) were formulated using CS, and HA were employed as a capping and targeting agent, and lactoferrin was added to improve drug bioavailability and targetability as well. The synthesized NPs were characterized using zeta potential analysis, particle size analysis, HR-TEM spectroscopy. The in vitro safety of QCHL-NPs was confirmed through toxicity assays on HepG2 cells. In vitro cytotoxicity data showed that QCHL-NPs required significantly lower concentrations than free QU to achieve significant inhibition 50% (IC50 − 10µM in 24 h and 1 µM in 48 h) of proliferation of HepG2 Cells (p < 0.01). In vivo animal study treatment with QCHL-NPs also significantly reduced antioxidant levels like TBARs (p < 0.01) and PC (p < 0.01) levels, while treatment with QCHL-NPs by increase caspase-3 (p < 0.001) analysis revealed apoptosis at the molecular level. Notably, this study successfully was synthesized QU-loaded CS nanoparticles with enhanced QU loading. The final formulation, Lf-coated, HA-capped CS NPs loaded with QU (QCHL-NPs), showed the dual targetability and antitumor efficacy compared to free QU. [ABSTRACT FROM AUTHOR]
Database: Energy & Power Source
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Header DbId: enr
DbLabel: Energy & Power Source
An: 190837710
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
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  Label: Title
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  Data: Formulation of Surface-Modified Quercetin-Loaded Chitosan-Hyaluronic Acid Nanoparticles for Targeted Hepatic Cancer Therapy.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Sahdev%2C+Anil+Kumar%22&quot;&gt;Sahdev, Anil Kumar&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Sana%2C+Siva+Sankar%22&quot;&gt;Sana, Siva Sankar&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gupta%2C+Priya%22&quot;&gt;Gupta, Priya&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Chandrakanta%22&quot;&gt;Chandrakanta&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Saadaoui%2C+S%2E%22&quot;&gt;Saadaoui, S.&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Raorane%2C+Chaitany+Jayprakash%22&quot;&gt;Raorane, Chaitany Jayprakash&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; chaitanyaraorane22@ynu.ac.kr&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kim%2C+Seong-Cheol%22&quot;&gt;Kim, Seong-Cheol&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Singh%2C+Anita%22&quot;&gt;Singh, Anita&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; dranitaku@gmail.com&lt;/i&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Journal+of+Polymers+%26+the+Environment%22&quot;&gt;Journal of Polymers &amp; the Environment&lt;/searchLink&gt;. Jan2026, Vol. 34 Issue 1, p1-15. 15p.
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Hepatic cancer remains one of the most difficult conditions to cure, particularly when it comes to detecting and eliminating malignant metastases. To overcome hepatic cancer, various strategies have been implemented in respect to targetability and safety concern. In this study, the anticancer agent quercetin (QU) was effectively encapsulated with biocompatible polymer chitosan (CS)-hyaluronic acid (HA) to improve its poor water solubility as well as dual targetability. The resulting QU-loaded nanoparticles (QU-NPs) were formulated using CS, and HA were employed as a capping and targeting agent, and lactoferrin was added to improve drug bioavailability and targetability as well. The synthesized NPs were characterized using zeta potential analysis, particle size analysis, HR-TEM spectroscopy. The in vitro safety of QCHL-NPs was confirmed through toxicity assays on HepG2 cells. In vitro cytotoxicity data showed that QCHL-NPs required significantly lower concentrations than free QU to achieve significant inhibition 50% (IC50 − 10&#181;M in 24 h and 1 &#181;M in 48 h) of proliferation of HepG2 Cells (p &lt; 0.01). In vivo animal study treatment with QCHL-NPs also significantly reduced antioxidant levels like TBARs (p &lt; 0.01) and PC (p &lt; 0.01) levels, while treatment with QCHL-NPs by increase caspase-3 (p &lt; 0.001) analysis revealed apoptosis at the molecular level. Notably, this study successfully was synthesized QU-loaded CS nanoparticles with enhanced QU loading. The final formulation, Lf-coated, HA-capped CS NPs loaded with QU (QCHL-NPs), showed the dual targetability and antitumor efficacy compared to free QU. [ABSTRACT FROM AUTHOR]
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=enr&AN=190837710
RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1007/s10924-025-03738-7
    Languages:
      – Code: eng
        Text: English
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      Pagination:
        PageCount: 15
        StartPage: 1
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      – TitleFull: Formulation of Surface-Modified Quercetin-Loaded Chitosan-Hyaluronic Acid Nanoparticles for Targeted Hepatic Cancer Therapy.
        Type: main
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          Name:
            NameFull: Sahdev, Anil Kumar
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            NameFull: Sana, Siva Sankar
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            NameFull: Gupta, Priya
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            NameFull: Chandrakanta
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            NameFull: Saadaoui, S.
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            NameFull: Raorane, Chaitany Jayprakash
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            NameFull: Kim, Seong-Cheol
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            NameFull: Singh, Anita
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          Dates:
            – D: 01
              M: 01
              Text: Jan2026
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 15662543
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              Value: 34
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              Value: 1
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            – TitleFull: Journal of Polymers & the Environment
              Type: main
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