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Bio-Derived Chitosan-Based ZnO/SnO₂ Nanocomposites: Evaluation of Cytotoxic and Biomedical Potential.

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Title: Bio-Derived Chitosan-Based ZnO/SnO₂ Nanocomposites: Evaluation of Cytotoxic and Biomedical Potential.
Authors: Devi, N. Ambika1 (AUTHOR), Mohan, R.1 (AUTHOR) rp.physics16@gmail.com, Raja, T. William2,3 (AUTHOR), Sundari, M. Meenakshi1 (AUTHOR), Ayyanar, M.4 (AUTHOR), Ravikumar, P.5 (AUTHOR), Perumal, Elumalai6 (AUTHOR), Ravichandran, K.7 (AUTHOR), Pillay, Michael2 (AUTHOR)
Source: Journal of Polymers & the Environment. Apr2026, Vol. 34 Issue 4, p1-18. 18p.
Abstract: The present study aims to synthesize a multifunctional nanocomposite, ZnO/SnO2/CS comprising zinc oxide (ZnO), tin oxide (SnO2), and crab shell-derived biopolymer chitosan (CS), and evaluate its abilities in antioxidant, antidiabetic, anti-inflammatory, and cytotoxic applications. Cancer is a group of illnesses caused by the uncontrolled growth and proliferation of abnormal cells, is a leading cause of death worldwide, responsible for nearly one in six deaths. The treatment of cancer becomes more complicated when a patient has several comorbidities. There is a need to develop anti-cancer agents with multiple health benefits. The structural, optical, and morphological properties of the synthesized nanocomposite were carried out by XRD, FTIR, FESEM, EDS with mapping, HR-TEM, XPS, and PL spectroscopy. The biomedical potential of the nanocomposite was evaluated by antioxidants (DPPH and superoxide), antidiabetic (α-glucosidase), anti-inflammatory (protein denaturation), and cytotoxicity (MTT) assays. The nanocomposite ZnO/SnO2/CS revealed 93.86 % and 93.28 % inhibition of free radicals in the DPPH and superoxide radical scavenging assays, with IC50 values of 107.07 ± 0.41 µg/mL and 140.66 ± 1.32 µg/mL, respectively. Similarly, the nanocomposite revealed better antioxidant and anti-inflammatory capability against α-glucosidase and protein denaturation assays with IC50 values of 102.68 ± 0.82 and 131.32 ± 0.97 µg/mL, respectively. The cytotoxicity assay showed an IC50 value of 15.197 ± 1.960 µg/mL for lung cancer cells (A-549) and 18.607 ± 2.641 µg/mL for breast cancer cells (MDA-MB-231). The cell morphological analyses and EtBr fluorescence staining demonstrated the apoptosis induced cell death. The multiple health benefits of the ZnO/SnO2/CS nanocomposite make it a favourable candidate for further anticancer research. [ABSTRACT FROM AUTHOR]
Database: Energy & Power Source
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Header DbId: enr
DbLabel: Energy & Power Source
An: 192580397
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Bio-Derived Chitosan-Based ZnO/SnO₂ Nanocomposites: Evaluation of Cytotoxic and Biomedical Potential.
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Polymers+%26+the+Environment%22">Journal of Polymers & the Environment</searchLink>. Apr2026, Vol. 34 Issue 4, p1-18. 18p.
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The present study aims to synthesize a multifunctional nanocomposite, ZnO/SnO2/CS comprising zinc oxide (ZnO), tin oxide (SnO2), and crab shell-derived biopolymer chitosan (CS), and evaluate its abilities in antioxidant, antidiabetic, anti-inflammatory, and cytotoxic applications. Cancer is a group of illnesses caused by the uncontrolled growth and proliferation of abnormal cells, is a leading cause of death worldwide, responsible for nearly one in six deaths. The treatment of cancer becomes more complicated when a patient has several comorbidities. There is a need to develop anti-cancer agents with multiple health benefits. The structural, optical, and morphological properties of the synthesized nanocomposite were carried out by XRD, FTIR, FESEM, EDS with mapping, HR-TEM, XPS, and PL spectroscopy. The biomedical potential of the nanocomposite was evaluated by antioxidants (DPPH and superoxide), antidiabetic (α-glucosidase), anti-inflammatory (protein denaturation), and cytotoxicity (MTT) assays. The nanocomposite ZnO/SnO2/CS revealed 93.86 % and 93.28 % inhibition of free radicals in the DPPH and superoxide radical scavenging assays, with IC50 values of 107.07 ± 0.41 µg/mL and 140.66 ± 1.32 µg/mL, respectively. Similarly, the nanocomposite revealed better antioxidant and anti-inflammatory capability against α-glucosidase and protein denaturation assays with IC50 values of 102.68 ± 0.82 and 131.32 ± 0.97 µg/mL, respectively. The cytotoxicity assay showed an IC50 value of 15.197 ± 1.960 µg/mL for lung cancer cells (A-549) and 18.607 ± 2.641 µg/mL for breast cancer cells (MDA-MB-231). The cell morphological analyses and EtBr fluorescence staining demonstrated the apoptosis induced cell death. The multiple health benefits of the ZnO/SnO2/CS nanocomposite make it a favourable candidate for further anticancer research. [ABSTRACT FROM AUTHOR]
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        Value: 10.1007/s10924-026-03811-9
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        Text: English
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      – TitleFull: Bio-Derived Chitosan-Based ZnO/SnO₂ Nanocomposites: Evaluation of Cytotoxic and Biomedical Potential.
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              Text: Apr2026
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              Y: 2026
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