Utilizing Juglans regia leaf extract for the production of uniform copper oxide nanoparticles: investigating antimicrobial characteristics.
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| Title: | Utilizing Juglans regia leaf extract for the production of uniform copper oxide nanoparticles: investigating antimicrobial characteristics. |
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| Authors: | Gürkaynak Altınçekiç, Tuba1 (AUTHOR) tubag@iuc.edu.tr, Akınan Oktay, Buse Simge1 (AUTHOR), Demirel, Rasime2 (AUTHOR) |
| Source: | Journal of Dispersion Science & Technology. 2026, Vol. 47 Issue 6, p1018-1034. 17p. |
| Subject Terms: | *Copper oxide, *English walnut, *Nanoparticles analysis, *Antifungal agents, *Mathematical optimization, *Experimental design, *Anti-infective agents, *Sustainable chemistry |
| Abstract: | Copper oxide nanoparticles (CuO NPs) are promising biologically active materials due to their broad-spectrum antimicrobial, antifungal, and antiviral properties. In this study, CuO NPs were synthesized using a green synthesis method employing Juglans regia L. (walnut) leaf extract under ambient conditions. A Box-Behnken design (BBD) was applied within the framework of response surface methodology to optimize the synthesis process, focusing on three critical parameters: copper salt concentration, extract volume, and calcination temperature. The structural and morphological characteristics of the synthesized CuO NPs were systematically investigated using X-ray diffraction (XRD), scanning electron microscopy (SEM-EDS), Fourier transform infrared spectrometry (FT-IR), ultraviolet–visible (UV–Vis) spectroscopy, and thermogravimetric analysis (TGA). The antimicrobial efficacy of the CuO NPs was also assessed by determining the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) against a range of bacterial strains, yeasts, and filamentous fungi. The findings demonstrated the successful formation of highly dispersed crystalline CuO NPs, with average crystallite sizes ranging from 13.39 to 25.26 nm. SEM analysis confirmed the presence of spherical, homogeneous NPs with an average diameter of 14 µm. The optimized synthesis conditions (0.125 M copper salt, 5% Juglans regia L. extract, and a calcination temperature of 300 °C) yielded CuO NPs with a mean crystallite size of 24.51 nm and an MFC of 113.051 µg/mL. Notably, the synthesized CuO NPs exhibited broad-spectrum antimicrobial activity, with some samples demonstrating superior antifungal efficacy compared to the control antifungal antibiotic at a concentration of 125 µg/mL. [ABSTRACT FROM AUTHOR] |
| Database: | Energy & Power Source |
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| Header | DbId: enr DbLabel: Energy & Power Source An: 193490280 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Utilizing Juglans regia leaf extract for the production of uniform copper oxide nanoparticles: investigating antimicrobial characteristics. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Gürkaynak+Altınçekiç%2C+Tuba%22">Gürkaynak Altınçekiç, Tuba</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> tubag@iuc.edu.tr</i><br /><searchLink fieldCode="AR" term="%22Akınan+Oktay%2C+Buse+Simge%22">Akınan Oktay, Buse Simge</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Demirel%2C+Rasime%22">Demirel, Rasime</searchLink><relatesTo>2</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Dispersion+Science+%26+Technology%22">Journal of Dispersion Science & Technology</searchLink>. 2026, Vol. 47 Issue 6, p1018-1034. 17p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22Copper+oxide%22">Copper oxide</searchLink><br />*<searchLink fieldCode="DE" term="%22English+walnut%22">English walnut</searchLink><br />*<searchLink fieldCode="DE" term="%22Nanoparticles+analysis%22">Nanoparticles analysis</searchLink><br />*<searchLink fieldCode="DE" term="%22Antifungal+agents%22">Antifungal agents</searchLink><br />*<searchLink fieldCode="DE" term="%22Mathematical+optimization%22">Mathematical optimization</searchLink><br />*<searchLink fieldCode="DE" term="%22Experimental+design%22">Experimental design</searchLink><br />*<searchLink fieldCode="DE" term="%22Anti-infective+agents%22">Anti-infective agents</searchLink><br />*<searchLink fieldCode="DE" term="%22Sustainable+chemistry%22">Sustainable chemistry</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Copper oxide nanoparticles (CuO NPs) are promising biologically active materials due to their broad-spectrum antimicrobial, antifungal, and antiviral properties. In this study, CuO NPs were synthesized using a green synthesis method employing Juglans regia L. (walnut) leaf extract under ambient conditions. A Box-Behnken design (BBD) was applied within the framework of response surface methodology to optimize the synthesis process, focusing on three critical parameters: copper salt concentration, extract volume, and calcination temperature. The structural and morphological characteristics of the synthesized CuO NPs were systematically investigated using X-ray diffraction (XRD), scanning electron microscopy (SEM-EDS), Fourier transform infrared spectrometry (FT-IR), ultraviolet–visible (UV–Vis) spectroscopy, and thermogravimetric analysis (TGA). The antimicrobial efficacy of the CuO NPs was also assessed by determining the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) against a range of bacterial strains, yeasts, and filamentous fungi. The findings demonstrated the successful formation of highly dispersed crystalline CuO NPs, with average crystallite sizes ranging from 13.39 to 25.26 nm. SEM analysis confirmed the presence of spherical, homogeneous NPs with an average diameter of 14 µm. The optimized synthesis conditions (0.125 M copper salt, 5% Juglans regia L. extract, and a calcination temperature of 300 °C) yielded CuO NPs with a mean crystallite size of 24.51 nm and an MFC of 113.051 µg/mL. Notably, the synthesized CuO NPs exhibited broad-spectrum antimicrobial activity, with some samples demonstrating superior antifungal efficacy compared to the control antifungal antibiotic at a concentration of 125 µg/mL. [ABSTRACT FROM AUTHOR] |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/01932691.2024.2428354 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 17 StartPage: 1018 Subjects: – SubjectFull: Copper oxide Type: general – SubjectFull: English walnut Type: general – SubjectFull: Nanoparticles analysis Type: general – SubjectFull: Antifungal agents Type: general – SubjectFull: Mathematical optimization Type: general – SubjectFull: Experimental design Type: general – SubjectFull: Anti-infective agents Type: general – SubjectFull: Sustainable chemistry Type: general Titles: – TitleFull: Utilizing Juglans regia leaf extract for the production of uniform copper oxide nanoparticles: investigating antimicrobial characteristics. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Gürkaynak Altınçekiç, Tuba – PersonEntity: Name: NameFull: Akınan Oktay, Buse Simge – PersonEntity: Name: NameFull: Demirel, Rasime IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: 2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 01932691 Numbering: – Type: volume Value: 47 – Type: issue Value: 6 Titles: – TitleFull: Journal of Dispersion Science & Technology Type: main |
| ResultId | 1 |
