Tailoring cilnidipine nanostructured lipid carriers loaded transdermal patch for the treatment of hypertension: optimization, ex vivo and in vivo studies.
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| Title: | Tailoring cilnidipine nanostructured lipid carriers loaded transdermal patch for the treatment of hypertension: optimization, ex vivo and in vivo studies. |
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| Authors: | Jaiswal, Ramankit1,2 (AUTHOR) ramankitjaiswal@gmail.com, Wadetwar, Rita2 (AUTHOR) |
| Source: | Journal of Dispersion Science & Technology. 2026, Vol. 47 Issue 6, p1060-1072. 13p. |
| Subject Terms: | *Drug delivery systems, *Bioavailability, *Skin absorption, *Pharmacokinetics, *Hypertension, *Transdermal medication, *Antihypertensive agents |
| Abstract: | The current investigation aimed to develop nanostructured lipid carriers (NLCs) as a potential transdermal drug delivery system for the improvement of cilnidipine (CIL) bioavailability. The high-pressure homogenization (HPH) method was utilized for the formulation of NLCs. Box-Behnken Design (BBD) was utilized to optimize CIL NLCs for entrapment efficiency, particle size and zeta potential. The resultant NLCs had a mean particle size of 98.2 ± 05.08 nm, a zeta potential of −16.1 ± 2.05 mV and an entrapment efficiency of 92.51 ± 4.18%. Transmission electron microscopy (TEM) revealed spherical or elongated particles for CIL-NLCs. The optimized NLCs were embedded in the transdermal patch and were formulated utilizing the solvent casting method and investigated for CIL content, physical characteristics, skin permeation and in vivo pharmacokinetics study. In vivo pharmacokinetics experiments with an NLCs-embedded transdermal patch show, an increase in Cmax and Tmax, 1305.66 ± 7.96 ng/mL and 4 h, respectively, when compared to the oral CIL dose. The flux values for ex vivo permeation studies for the CIL NLCs patch were determined to be 82.54 ± 4.80 µg/cm2/h. The bioavailability of CIL-loaded NLCs transdermal patch was found to be 2.9-fold greater than that of oral drug suspension, thus confirming the improvement of bioavailability of CIL by NLCs loaded transdermal patch. [ABSTRACT FROM AUTHOR] |
| Database: | Energy & Power Source |
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| Header | DbId: enr DbLabel: Energy & Power Source An: 193490282 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Tailoring cilnidipine nanostructured lipid carriers loaded transdermal patch for the treatment of hypertension: optimization, ex vivo and in vivo studies. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Jaiswal%2C+Ramankit%22">Jaiswal, Ramankit</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> ramankitjaiswal@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Wadetwar%2C+Rita%22">Wadetwar, Rita</searchLink><relatesTo>2</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Dispersion+Science+%26+Technology%22">Journal of Dispersion Science & Technology</searchLink>. 2026, Vol. 47 Issue 6, p1060-1072. 13p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22Drug+delivery+systems%22">Drug delivery systems</searchLink><br />*<searchLink fieldCode="DE" term="%22Bioavailability%22">Bioavailability</searchLink><br />*<searchLink fieldCode="DE" term="%22Skin+absorption%22">Skin absorption</searchLink><br />*<searchLink fieldCode="DE" term="%22Pharmacokinetics%22">Pharmacokinetics</searchLink><br />*<searchLink fieldCode="DE" term="%22Hypertension%22">Hypertension</searchLink><br />*<searchLink fieldCode="DE" term="%22Transdermal+medication%22">Transdermal medication</searchLink><br />*<searchLink fieldCode="DE" term="%22Antihypertensive+agents%22">Antihypertensive agents</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The current investigation aimed to develop nanostructured lipid carriers (NLCs) as a potential transdermal drug delivery system for the improvement of cilnidipine (CIL) bioavailability. The high-pressure homogenization (HPH) method was utilized for the formulation of NLCs. Box-Behnken Design (BBD) was utilized to optimize CIL NLCs for entrapment efficiency, particle size and zeta potential. The resultant NLCs had a mean particle size of 98.2 ± 05.08 nm, a zeta potential of −16.1 ± 2.05 mV and an entrapment efficiency of 92.51 ± 4.18%. Transmission electron microscopy (TEM) revealed spherical or elongated particles for CIL-NLCs. The optimized NLCs were embedded in the transdermal patch and were formulated utilizing the solvent casting method and investigated for CIL content, physical characteristics, skin permeation and in vivo pharmacokinetics study. In vivo pharmacokinetics experiments with an NLCs-embedded transdermal patch show, an increase in Cmax and Tmax, 1305.66 ± 7.96 ng/mL and 4 h, respectively, when compared to the oral CIL dose. The flux values for ex vivo permeation studies for the CIL NLCs patch were determined to be 82.54 ± 4.80 µg/cm2/h. The bioavailability of CIL-loaded NLCs transdermal patch was found to be 2.9-fold greater than that of oral drug suspension, thus confirming the improvement of bioavailability of CIL by NLCs loaded transdermal patch. [ABSTRACT FROM AUTHOR] |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=enr&AN=193490282 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/01932691.2024.2431085 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 1060 Subjects: – SubjectFull: Drug delivery systems Type: general – SubjectFull: Bioavailability Type: general – SubjectFull: Skin absorption Type: general – SubjectFull: Pharmacokinetics Type: general – SubjectFull: Hypertension Type: general – SubjectFull: Transdermal medication Type: general – SubjectFull: Antihypertensive agents Type: general Titles: – TitleFull: Tailoring cilnidipine nanostructured lipid carriers loaded transdermal patch for the treatment of hypertension: optimization, ex vivo and in vivo studies. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Jaiswal, Ramankit – PersonEntity: Name: NameFull: Wadetwar, Rita IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: 2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 01932691 Numbering: – Type: volume Value: 47 – Type: issue Value: 6 Titles: – TitleFull: Journal of Dispersion Science & Technology Type: main |
| ResultId | 1 |
