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Promethium-149 (149Pm) as a potential theranostic radioisotope: a feasibility study of 149Pm production at the Bandung TRIGA research reactor.

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Title: Promethium-149 (149Pm) as a potential theranostic radioisotope: a feasibility study of 149Pm production at the Bandung TRIGA research reactor.
Authors: Aziz, Azmairit1 (AUTHOR), Umar, Efrizon2 (AUTHOR), Basuki, Prasetyo3 (AUTHOR), Ratnawati, Neni3 (AUTHOR), Fathadina, Almira4 (AUTHOR), Permana, Sidik5 (AUTHOR), Ramadhan, Anwar Ilmar6 (AUTHOR) anwar.ilmar@umj.ac.id
Source: Journal of Radioanalytical & Nuclear Chemistry. May2026, Vol. 335 Issue 5, p3781-3796. 16p.
Subject Terms: *Radioisotopes, *Research reactors, *Nuclear medicine, *Nuclear activation analysis, *Radiopharmaceuticals, *Cancer treatment
Geographic Terms: Bandung (Indonesia)
Abstract: Promethium-149 (149Pm) is a no carrier added radiolanthanide that emits moderate-energy beta particles and has high potential as a novel theranostic radioisotope for nuclear medicine applications. This study describes the production of the 149Pm radioisotope from enriched neodymium oxide (Nd2O3) targets at the Bandung TRIGA research reactor and its supporting facilities, including theoretical calculations using computer codes, target preparation, neutron activation, separation of 149Pm radionuclide from Nd/Pm matrix, purification, and physicochemical characterization. The obtained 149Pm was in the form of a 149PmCl3 solution, which remained stable at room temperature for up to 8 days after preparation with high radiochemical and radionuclide purities, thereby fulfilling the requirements for use as a precursor in the preparation of various targeted radiopharmaceuticals for cancer therapy. [ABSTRACT FROM AUTHOR]
Database: Energy & Power Source
FullText Text:
  Availability: 0
Header DbId: enr
DbLabel: Energy & Power Source
An: 194006681
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Promethium-149 (<superscript>149</superscript>Pm) as a potential theranostic radioisotope: a feasibility study of <superscript>149</superscript>Pm production at the Bandung TRIGA research reactor.
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  Data: <searchLink fieldCode="AR" term="%22Aziz%2C+Azmairit%22">Aziz, Azmairit</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Umar%2C+Efrizon%22">Umar, Efrizon</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Basuki%2C+Prasetyo%22">Basuki, Prasetyo</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ratnawati%2C+Neni%22">Ratnawati, Neni</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fathadina%2C+Almira%22">Fathadina, Almira</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Permana%2C+Sidik%22">Permana, Sidik</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ramadhan%2C+Anwar+Ilmar%22">Ramadhan, Anwar Ilmar</searchLink><relatesTo>6</relatesTo> (AUTHOR)<i> anwar.ilmar@umj.ac.id</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Radioanalytical+%26+Nuclear+Chemistry%22">Journal of Radioanalytical & Nuclear Chemistry</searchLink>. May2026, Vol. 335 Issue 5, p3781-3796. 16p.
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  Data: *<searchLink fieldCode="DE" term="%22Radioisotopes%22">Radioisotopes</searchLink><br />*<searchLink fieldCode="DE" term="%22Research+reactors%22">Research reactors</searchLink><br />*<searchLink fieldCode="DE" term="%22Nuclear+medicine%22">Nuclear medicine</searchLink><br />*<searchLink fieldCode="DE" term="%22Nuclear+activation+analysis%22">Nuclear activation analysis</searchLink><br />*<searchLink fieldCode="DE" term="%22Radiopharmaceuticals%22">Radiopharmaceuticals</searchLink><br />*<searchLink fieldCode="DE" term="%22Cancer+treatment%22">Cancer treatment</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Bandung+%28Indonesia%29%22">Bandung (Indonesia)</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Promethium-149 (149Pm) is a no carrier added radiolanthanide that emits moderate-energy beta particles and has high potential as a novel theranostic radioisotope for nuclear medicine applications. This study describes the production of the 149Pm radioisotope from enriched neodymium oxide (Nd2O3) targets at the Bandung TRIGA research reactor and its supporting facilities, including theoretical calculations using computer codes, target preparation, neutron activation, separation of 149Pm radionuclide from Nd/Pm matrix, purification, and physicochemical characterization. The obtained 149Pm was in the form of a 149PmCl3 solution, which remained stable at room temperature for up to 8 days after preparation with high radiochemical and radionuclide purities, thereby fulfilling the requirements for use as a precursor in the preparation of various targeted radiopharmaceuticals for cancer therapy. [ABSTRACT FROM AUTHOR]
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=enr&AN=194006681
RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1007/s10967-026-10894-0
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 16
        StartPage: 3781
    Subjects:
      – SubjectFull: Radioisotopes
        Type: general
      – SubjectFull: Research reactors
        Type: general
      – SubjectFull: Nuclear medicine
        Type: general
      – SubjectFull: Nuclear activation analysis
        Type: general
      – SubjectFull: Radiopharmaceuticals
        Type: general
      – SubjectFull: Cancer treatment
        Type: general
      – SubjectFull: Bandung (Indonesia)
        Type: general
    Titles:
      – TitleFull: Promethium-149 (149Pm) as a potential theranostic radioisotope: a feasibility study of 149Pm production at the Bandung TRIGA research reactor.
        Type: main
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            NameFull: Aziz, Azmairit
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            NameFull: Umar, Efrizon
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            NameFull: Basuki, Prasetyo
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            NameFull: Ratnawati, Neni
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            NameFull: Fathadina, Almira
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            NameFull: Permana, Sidik
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            NameFull: Ramadhan, Anwar Ilmar
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            – D: 01
              M: 05
              Text: May2026
              Type: published
              Y: 2026
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              Value: 02365731
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              Value: 335
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              Value: 5
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            – TitleFull: Journal of Radioanalytical & Nuclear Chemistry
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