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Enhanced stability, permeability, and bioavailability of hydrophobic compounds in cosmetics through a time-efficient and convenient prenanoemulsion technology.

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Title: Enhanced stability, permeability, and bioavailability of hydrophobic compounds in cosmetics through a time-efficient and convenient prenanoemulsion technology.
Authors: Meng, Hong1 (AUTHOR), He, Huanfan1 (AUTHOR), He, Yifan1 (AUTHOR), Pei, Xiaojing1 (AUTHOR), Dong, Yinmao1 (AUTHOR), Li, Shujing1 (AUTHOR), Zhang, Ze1 (AUTHOR) zhangze@btbu.edu.cn
Source: Journal of Dispersion Science & Technology. 2026, Vol. 47 Issue 8, p1435-1443. 9p.
Subject Terms: *Permeability, *Bioavailability, *Microencapsulation, *Microemulsions, *Nanostructured materials, *Cosmetics, *Chemical stability, *Hydrophobic compounds
Abstract: While some cosmetic hydrophobic compounds have superior physiological activities, their formulation applications are limited due to low water solubility, stability, and bioavailability. This study employed pre-cationic nanoemulsion (PCNE) as a matrix to directly encapsulate fat-soluble raw materials through one-step high-pressure homogenization to simplify the nanoemulsion preparation process and reduce preparation time. The PCNE exhibited a spherical structure with small particle size (<100 nm) and high encapsulation efficiency (mostly > 90%), demonstrating excellent stability before and after encapsulating the raw materials. The antioxidant activity, in vitro release, and in vitro permeation of glabridin pre-cationic nanoemulsion (GLA-PCNE) were investigated. The experimental results revealed that GLA-PCNE possessed significantly enhanced DPPH radical scavenging ability compared to the free compound while exhibiting improved skin permeation properties; furthermore, it demonstrated controlled release characteristics. Based on these findings, PCNE hold promise as potential nanocarriers for expedited and convenient delivery of hydrophobic ingredients in cosmetic applications. [ABSTRACT FROM AUTHOR]
Database: Energy & Power Source
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Header DbId: enr
DbLabel: Energy & Power Source
An: 194165976
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PubTypeId: academicJournal
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  Label: Title
  Group: Ti
  Data: Enhanced stability, permeability, and bioavailability of hydrophobic compounds in cosmetics through a time-efficient and convenient prenanoemulsion technology.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Meng%2C+Hong%22&quot;&gt;Meng, Hong&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22He%2C+Huanfan%22&quot;&gt;He, Huanfan&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22He%2C+Yifan%22&quot;&gt;He, Yifan&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Pei%2C+Xiaojing%22&quot;&gt;Pei, Xiaojing&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Dong%2C+Yinmao%22&quot;&gt;Dong, Yinmao&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Li%2C+Shujing%22&quot;&gt;Li, Shujing&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zhang%2C+Ze%22&quot;&gt;Zhang, Ze&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; zhangze@btbu.edu.cn&lt;/i&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Journal+of+Dispersion+Science+%26+Technology%22&quot;&gt;Journal of Dispersion Science &amp; Technology&lt;/searchLink&gt;. 2026, Vol. 47 Issue 8, p1435-1443. 9p.
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: *&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Permeability%22&quot;&gt;Permeability&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Bioavailability%22&quot;&gt;Bioavailability&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Microencapsulation%22&quot;&gt;Microencapsulation&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Microemulsions%22&quot;&gt;Microemulsions&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Nanostructured+materials%22&quot;&gt;Nanostructured materials&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cosmetics%22&quot;&gt;Cosmetics&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Chemical+stability%22&quot;&gt;Chemical stability&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Hydrophobic+compounds%22&quot;&gt;Hydrophobic compounds&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: While some cosmetic hydrophobic compounds have superior physiological activities, their formulation applications are limited due to low water solubility, stability, and bioavailability. This study employed pre-cationic nanoemulsion (PCNE) as a matrix to directly encapsulate fat-soluble raw materials through one-step high-pressure homogenization to simplify the nanoemulsion preparation process and reduce preparation time. The PCNE exhibited a spherical structure with small particle size (&lt;100 nm) and high encapsulation efficiency (mostly &gt; 90%), demonstrating excellent stability before and after encapsulating the raw materials. The antioxidant activity, in vitro release, and in vitro permeation of glabridin pre-cationic nanoemulsion (GLA-PCNE) were investigated. The experimental results revealed that GLA-PCNE possessed significantly enhanced DPPH radical scavenging ability compared to the free compound while exhibiting improved skin permeation properties; furthermore, it demonstrated controlled release characteristics. Based on these findings, PCNE hold promise as potential nanocarriers for expedited and convenient delivery of hydrophobic ingredients in cosmetic applications. [ABSTRACT FROM AUTHOR]
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=enr&AN=194165976
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/01932691.2024.2444985
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 1435
    Subjects:
      – SubjectFull: Permeability
        Type: general
      – SubjectFull: Bioavailability
        Type: general
      – SubjectFull: Microencapsulation
        Type: general
      – SubjectFull: Microemulsions
        Type: general
      – SubjectFull: Nanostructured materials
        Type: general
      – SubjectFull: Cosmetics
        Type: general
      – SubjectFull: Chemical stability
        Type: general
      – SubjectFull: Hydrophobic compounds
        Type: general
    Titles:
      – TitleFull: Enhanced stability, permeability, and bioavailability of hydrophobic compounds in cosmetics through a time-efficient and convenient prenanoemulsion technology.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Meng, Hong
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          Name:
            NameFull: He, Huanfan
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            NameFull: He, Yifan
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            NameFull: Pei, Xiaojing
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            NameFull: Dong, Yinmao
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            NameFull: Li, Shujing
      – PersonEntity:
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            NameFull: Zhang, Ze
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          Dates:
            – D: 01
              M: 07
              Text: 2026
              Type: published
              Y: 2026
          Identifiers:
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              Value: 01932691
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              Value: 47
            – Type: issue
              Value: 8
          Titles:
            – TitleFull: Journal of Dispersion Science & Technology
              Type: main
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