Enhanced stability, permeability, and bioavailability of hydrophobic compounds in cosmetics through a time-efficient and convenient prenanoemulsion technology.
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| Title: | Enhanced stability, permeability, and bioavailability of hydrophobic compounds in cosmetics through a time-efficient and convenient prenanoemulsion technology. |
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| Authors: | Meng, Hong1 (AUTHOR), He, Huanfan1 (AUTHOR), He, Yifan1 (AUTHOR), Pei, Xiaojing1 (AUTHOR), Dong, Yinmao1 (AUTHOR), Li, Shujing1 (AUTHOR), Zhang, Ze1 (AUTHOR) zhangze@btbu.edu.cn |
| Source: | Journal of Dispersion Science & Technology. 2026, Vol. 47 Issue 8, p1435-1443. 9p. |
| Subject Terms: | *Permeability, *Bioavailability, *Microencapsulation, *Microemulsions, *Nanostructured materials, *Cosmetics, *Chemical stability, *Hydrophobic compounds |
| Abstract: | While some cosmetic hydrophobic compounds have superior physiological activities, their formulation applications are limited due to low water solubility, stability, and bioavailability. This study employed pre-cationic nanoemulsion (PCNE) as a matrix to directly encapsulate fat-soluble raw materials through one-step high-pressure homogenization to simplify the nanoemulsion preparation process and reduce preparation time. The PCNE exhibited a spherical structure with small particle size (<100 nm) and high encapsulation efficiency (mostly > 90%), demonstrating excellent stability before and after encapsulating the raw materials. The antioxidant activity, in vitro release, and in vitro permeation of glabridin pre-cationic nanoemulsion (GLA-PCNE) were investigated. The experimental results revealed that GLA-PCNE possessed significantly enhanced DPPH radical scavenging ability compared to the free compound while exhibiting improved skin permeation properties; furthermore, it demonstrated controlled release characteristics. Based on these findings, PCNE hold promise as potential nanocarriers for expedited and convenient delivery of hydrophobic ingredients in cosmetic applications. [ABSTRACT FROM AUTHOR] |
| Database: | Energy & Power Source |
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| Abstract: | While some cosmetic hydrophobic compounds have superior physiological activities, their formulation applications are limited due to low water solubility, stability, and bioavailability. This study employed pre-cationic nanoemulsion (PCNE) as a matrix to directly encapsulate fat-soluble raw materials through one-step high-pressure homogenization to simplify the nanoemulsion preparation process and reduce preparation time. The PCNE exhibited a spherical structure with small particle size (<100 nm) and high encapsulation efficiency (mostly > 90%), demonstrating excellent stability before and after encapsulating the raw materials. The antioxidant activity, in vitro release, and in vitro permeation of glabridin pre-cationic nanoemulsion (GLA-PCNE) were investigated. The experimental results revealed that GLA-PCNE possessed significantly enhanced DPPH radical scavenging ability compared to the free compound while exhibiting improved skin permeation properties; furthermore, it demonstrated controlled release characteristics. Based on these findings, PCNE hold promise as potential nanocarriers for expedited and convenient delivery of hydrophobic ingredients in cosmetic applications. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 01932691 |
| DOI: | 10.1080/01932691.2024.2444985 |
