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Multi-Class Pharmaceutical Profiling Along an Urbanization Gradient in a Tropical Megacity River: Evidence for Cumulative Loading and Limited Attenuation.

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Title: Multi-Class Pharmaceutical Profiling Along an Urbanization Gradient in a Tropical Megacity River: Evidence for Cumulative Loading and Limited Attenuation.
Authors: Koagouw, Wulan1 (AUTHOR) wulan.koagouw@brin.go.id, Subandi, Riyana2 (AUTHOR), Adriany, Rina3 (AUTHOR), Hazell, Richard J.4 (AUTHOR) r.j.hazell@sussex.ac.uk
Source: Bulletin of Environmental Contamination & Toxicology. Jul2026, Vol. 117 Issue 1, p1-8. 8p.
Subject Terms: *Pollution, *Wastewater treatment, *Riparian areas, *Antibiotics, *Cardiovascular agents, *Watersheds, *Analgesics
Geographic Terms: Jakarta (Indonesia)
Abstract: Urban pharmaceutical pollution threatens aquatic ecosystems and human health, yet tropical watersheds remain understudied compared to temperate systems. Here we demonstrate a gradient-based approach to diagnose cumulative pharmaceutical loading in Jakarta's Ciliwung River. We analyzed 53 compounds across eight sites and detected 13 pharmaceuticals spanning antibiotics, analgesics, cardiovascular agents, and iodinated contrast media (ICMs). Downstream concentrations of the pooled contaminants increased significantly (R2 = 0.209, p < 0.001), with gabapentin showing the strongest cumulative gradient (R2 = 0.895, p < 0.001). Eleven compounds displayed monotonic downstream increases, indicating cumulative loading and limited attenuation. Localized spikes for diclofenac and metronidazole suggest point-source inputs from healthcare or residential discharge. The study establishes a baseline for a highly urbanized watershed while illustrating monitoring and source-control priorities relevant to tropical megacities with limited wastewater treatment capacity. It identifies gabapentin as a candidate sentinel indicator for future studies. The findings of this study can aid in development of effective strategies for managing emerging contaminants in the Ciliwung River and other urban rivers facing similar challenges. [ABSTRACT FROM AUTHOR]
Database: Energy & Power Source
FullText Text:
  Availability: 0
Header DbId: enr
DbLabel: Energy & Power Source
An: 194611952
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
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  Data: Multi-Class Pharmaceutical Profiling Along an Urbanization Gradient in a Tropical Megacity River: Evidence for Cumulative Loading and Limited Attenuation.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Koagouw%2C+Wulan%22&quot;&gt;Koagouw, Wulan&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; wulan.koagouw@brin.go.id&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Subandi%2C+Riyana%22&quot;&gt;Subandi, Riyana&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Adriany%2C+Rina%22&quot;&gt;Adriany, Rina&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hazell%2C+Richard+J%2E%22&quot;&gt;Hazell, Richard J.&lt;/searchLink&gt;&lt;relatesTo&gt;4&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; r.j.hazell@sussex.ac.uk&lt;/i&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Bulletin+of+Environmental+Contamination+%26+Toxicology%22&quot;&gt;Bulletin of Environmental Contamination &amp; Toxicology&lt;/searchLink&gt;. Jul2026, Vol. 117 Issue 1, p1-8. 8p.
– Name: Subject
  Label: Subject Terms
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  Data: *&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Pollution%22&quot;&gt;Pollution&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Wastewater+treatment%22&quot;&gt;Wastewater treatment&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Riparian+areas%22&quot;&gt;Riparian areas&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Antibiotics%22&quot;&gt;Antibiotics&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cardiovascular+agents%22&quot;&gt;Cardiovascular agents&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Watersheds%22&quot;&gt;Watersheds&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Analgesics%22&quot;&gt;Analgesics&lt;/searchLink&gt;
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Jakarta+%28Indonesia%29%22&quot;&gt;Jakarta (Indonesia)&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Urban pharmaceutical pollution threatens aquatic ecosystems and human health, yet tropical watersheds remain understudied compared to temperate systems. Here we demonstrate a gradient-based approach to diagnose cumulative pharmaceutical loading in Jakarta&#39;s Ciliwung River. We analyzed 53 compounds across eight sites and detected 13 pharmaceuticals spanning antibiotics, analgesics, cardiovascular agents, and iodinated contrast media (ICMs). Downstream concentrations of the pooled contaminants increased significantly (R2 = 0.209, p &lt; 0.001), with gabapentin showing the strongest cumulative gradient (R2 = 0.895, p &lt; 0.001). Eleven compounds displayed monotonic downstream increases, indicating cumulative loading and limited attenuation. Localized spikes for diclofenac and metronidazole suggest point-source inputs from healthcare or residential discharge. The study establishes a baseline for a highly urbanized watershed while illustrating monitoring and source-control priorities relevant to tropical megacities with limited wastewater treatment capacity. It identifies gabapentin as a candidate sentinel indicator for future studies. The findings of this study can aid in development of effective strategies for managing emerging contaminants in the Ciliwung River and other urban rivers facing similar challenges. [ABSTRACT FROM AUTHOR]
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=enr&AN=194611952
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s00128-026-04271-6
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 1
    Subjects:
      – SubjectFull: Pollution
        Type: general
      – SubjectFull: Wastewater treatment
        Type: general
      – SubjectFull: Riparian areas
        Type: general
      – SubjectFull: Antibiotics
        Type: general
      – SubjectFull: Cardiovascular agents
        Type: general
      – SubjectFull: Watersheds
        Type: general
      – SubjectFull: Analgesics
        Type: general
      – SubjectFull: Jakarta (Indonesia)
        Type: general
    Titles:
      – TitleFull: Multi-Class Pharmaceutical Profiling Along an Urbanization Gradient in a Tropical Megacity River: Evidence for Cumulative Loading and Limited Attenuation.
        Type: main
  BibRelationships:
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      – PersonEntity:
          Name:
            NameFull: Koagouw, Wulan
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          Name:
            NameFull: Subandi, Riyana
      – PersonEntity:
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            NameFull: Adriany, Rina
      – PersonEntity:
          Name:
            NameFull: Hazell, Richard J.
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          Dates:
            – D: 01
              M: 07
              Text: Jul2026
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 00074861
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            – Type: volume
              Value: 117
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Bulletin of Environmental Contamination & Toxicology
              Type: main
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