View in EDS

Synthesis of Bioactive Scaffold BC-co-CMCs-HAp Incorporated with ZnO@GO for Bone Tissue Engineering.

Saved in:
Bibliographic Details
Title: Synthesis of Bioactive Scaffold BC-co-CMCs-HAp Incorporated with ZnO@GO for Bone Tissue Engineering.
Authors: Khan, Muhammad Umar Aslam1,2 (AUTHOR) umar007khan@gmail.com, Munir, Talha3 (AUTHOR), Yousaf, Saiqa4 (AUTHOR), Abdal-Hay, Abdalla5 (AUTHOR), Fouad, Hassan6 (AUTHOR), Xu, Yichi7 (AUTHOR) mrxuyichi@163.com, Hashem, Mohamed8 (AUTHOR) mihashem@ksu.edu.sa
Source: Journal of Polymers & the Environment. Jul2026, Vol. 34 Issue 7, p1-18. 18p.
Abstract: Therapeutically, repair and efficient healing of bone injuries are challenging and bone tissue engineering (BTE) is an emerging filed to resolve bone defects. It is performed without the typical complications associated with conventional autologous or allogeneic bone transplantation. A cost-effective bioactive polymeric nanocomposite was synthesised from nanocomposite (ZnO@GO) bacterial cellulose, carboxymethyl chitosan and acrylic acid by free radical polymerisation. Porous scaffolds were freeze-dried and the structure, surface morphology, elemental composition and mechanical properties were investigated by FTIR, XRD, SEM-EDX and UTM. Then, the physicochemical characteristics of scaffolds were determined by swelling in multiple media (Aqueous, PBS, and NaCl at 37 °C) and degradation in PBS media (pH 7.4 at 37 °C) to evaluate pH-responsive swelling and degradation of bioactive scaffolds. Antimicrobial and hemocompatibility investigations were carried out and these scaffolds exhibited excellent antibacterial activity and hemocompatibility. All scaffolds demonstrated significant biomineralization and promise for bone regeneration. The cytocompatibility was examined using preosteoblast (MC3T3-E1) cells by analysing cell viability, proliferation and morphology at different time periods. All scaffolds were evaluated for their structural, morphological, mechanical, and physicochemical properties, and BCGZ1.5 was found to be the most suitable scaffold formulation. Thus, the results show that these scaffolds would be a potential material for repair and regeneration of defective bone by providing regulated, and desirable physicochemical and biomechanical characteristics. [ABSTRACT FROM AUTHOR]
Database: Energy & Power Source
FullText Text:
  Availability: 0
Header DbId: enr
DbLabel: Energy & Power Source
An: 194710420
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Synthesis of Bioactive Scaffold BC-co-CMCs-HAp Incorporated with ZnO@GO for Bone Tissue Engineering.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Khan%2C+Muhammad+Umar+Aslam%22">Khan, Muhammad Umar Aslam</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> umar007khan@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Munir%2C+Talha%22">Munir, Talha</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yousaf%2C+Saiqa%22">Yousaf, Saiqa</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Abdal-Hay%2C+Abdalla%22">Abdal-Hay, Abdalla</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fouad%2C+Hassan%22">Fouad, Hassan</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xu%2C+Yichi%22">Xu, Yichi</searchLink><relatesTo>7</relatesTo> (AUTHOR)<i> mrxuyichi@163.com</i><br /><searchLink fieldCode="AR" term="%22Hashem%2C+Mohamed%22">Hashem, Mohamed</searchLink><relatesTo>8</relatesTo> (AUTHOR)<i> mihashem@ksu.edu.sa</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Journal+of+Polymers+%26+the+Environment%22">Journal of Polymers & the Environment</searchLink>. Jul2026, Vol. 34 Issue 7, p1-18. 18p.
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Therapeutically, repair and efficient healing of bone injuries are challenging and bone tissue engineering (BTE) is an emerging filed to resolve bone defects. It is performed without the typical complications associated with conventional autologous or allogeneic bone transplantation. A cost-effective bioactive polymeric nanocomposite was synthesised from nanocomposite (ZnO@GO) bacterial cellulose, carboxymethyl chitosan and acrylic acid by free radical polymerisation. Porous scaffolds were freeze-dried and the structure, surface morphology, elemental composition and mechanical properties were investigated by FTIR, XRD, SEM-EDX and UTM. Then, the physicochemical characteristics of scaffolds were determined by swelling in multiple media (Aqueous, PBS, and NaCl at 37 °C) and degradation in PBS media (pH 7.4 at 37 °C) to evaluate pH-responsive swelling and degradation of bioactive scaffolds. Antimicrobial and hemocompatibility investigations were carried out and these scaffolds exhibited excellent antibacterial activity and hemocompatibility. All scaffolds demonstrated significant biomineralization and promise for bone regeneration. The cytocompatibility was examined using preosteoblast (MC3T3-E1) cells by analysing cell viability, proliferation and morphology at different time periods. All scaffolds were evaluated for their structural, morphological, mechanical, and physicochemical properties, and BCGZ1.5 was found to be the most suitable scaffold formulation. Thus, the results show that these scaffolds would be a potential material for repair and regeneration of defective bone by providing regulated, and desirable physicochemical and biomechanical characteristics. [ABSTRACT FROM AUTHOR]
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=enr&AN=194710420
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s10924-026-03897-1
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 18
        StartPage: 1
    Titles:
      – TitleFull: Synthesis of Bioactive Scaffold BC-co-CMCs-HAp Incorporated with ZnO@GO for Bone Tissue Engineering.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Khan, Muhammad Umar Aslam
      – PersonEntity:
          Name:
            NameFull: Munir, Talha
      – PersonEntity:
          Name:
            NameFull: Yousaf, Saiqa
      – PersonEntity:
          Name:
            NameFull: Abdal-Hay, Abdalla
      – PersonEntity:
          Name:
            NameFull: Fouad, Hassan
      – PersonEntity:
          Name:
            NameFull: Xu, Yichi
      – PersonEntity:
          Name:
            NameFull: Hashem, Mohamed
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 07
              Text: Jul2026
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 15662543
          Numbering:
            – Type: volume
              Value: 34
            – Type: issue
              Value: 7
          Titles:
            – TitleFull: Journal of Polymers & the Environment
              Type: main
ResultId 1