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A Novel Role for the Rat Retrosplenial Cortex in Cognitive Control

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Title: A Novel Role for the Rat Retrosplenial Cortex in Cognitive Control
Authors: Nelson, Andrew J. D., Hindley, Emma L., Haddon, Josephine E., Vann, Seralynne D., Aggleton, John P.
Source: Learning & Memory. Feb 2014 21(2):90-97.
Availability: Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Peer Reviewed: Y
Page Count: 8
Publication Date: 2014
Document Type: Journal Articles
Reports - Research
Descriptors: Animals, Cognitive Ability, Brain Hemisphere Functions, Correlation, Cues, Conditioning, Visual Discrimination, Auditory Discrimination, Conflict, Context Effect
Assessment and Survey Identifiers: Stroop Color Word Test
DOI: 10.1101/lm.032136.113
ISSN: 1072-0502
Abstract: By virtue of its frontal and hippocampal connections, the retrosplenial cortex is uniquely placed to support cognition. Here, we tested whether the retrosplenial cortex is required for frontal tasks analogous to the Stroop Test, i.e., for the ability to select between conflicting responses and inhibit responding to task-irrelevant cues. Rats first acquired two instrumental conditional discriminations, one auditory and one visual, set in two distinct contexts. As a result, rats were rewarded for pressing either the right or left lever when a particular auditory or visual signal was present. In extinction, rats received compound stimuli that either comprised the auditory and visual elements that signaled the same lever response (congruent) or signaled different lever responses (incongruent) during training. On conflict (incongruent) trials, lever selection by sham-operated animals followed the stimulus element that had previously been trained in that same test context, whereas animals with retrosplenial cortex lesions failed to disambiguate the conflicting response cues. Subsequent experiments demonstrated that this abnormality on conflict trials was not due to a failure in distinguishing the contexts. Rather, these data reveal the selective involvement of the rat retrosplenial cortex in response conflict, and so extend the frontal system underlying cognitive control.
Abstractor: As Provided
Number of References: 45
Entry Date: 2014
Accession Number: EJ1027256
Database: ERIC
FullText Text:
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  Data: A Novel Role for the Rat Retrosplenial Cortex in Cognitive Control
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  Data: <searchLink fieldCode="AR" term="%22Nelson%2C+Andrew+J%2E+D%2E%22">Nelson, Andrew J. D.</searchLink><br /><searchLink fieldCode="AR" term="%22Hindley%2C+Emma+L%2E%22">Hindley, Emma L.</searchLink><br /><searchLink fieldCode="AR" term="%22Haddon%2C+Josephine+E%2E%22">Haddon, Josephine E.</searchLink><br /><searchLink fieldCode="AR" term="%22Vann%2C+Seralynne+D%2E%22">Vann, Seralynne D.</searchLink><br /><searchLink fieldCode="AR" term="%22Aggleton%2C+John+P%2E%22">Aggleton, John P.</searchLink>
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  Data: <searchLink fieldCode="SO" term="%22Learning+%26+Memory%22"><i>Learning & Memory</i></searchLink>. Feb 2014 21(2):90-97.
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  Data: Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
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  Data: 8
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  Data: Journal Articles<br />Reports - Research
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  Data: 10.1101/lm.032136.113
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  Data: 1072-0502
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: By virtue of its frontal and hippocampal connections, the retrosplenial cortex is uniquely placed to support cognition. Here, we tested whether the retrosplenial cortex is required for frontal tasks analogous to the Stroop Test, i.e., for the ability to select between conflicting responses and inhibit responding to task-irrelevant cues. Rats first acquired two instrumental conditional discriminations, one auditory and one visual, set in two distinct contexts. As a result, rats were rewarded for pressing either the right or left lever when a particular auditory or visual signal was present. In extinction, rats received compound stimuli that either comprised the auditory and visual elements that signaled the same lever response (congruent) or signaled different lever responses (incongruent) during training. On conflict (incongruent) trials, lever selection by sham-operated animals followed the stimulus element that had previously been trained in that same test context, whereas animals with retrosplenial cortex lesions failed to disambiguate the conflicting response cues. Subsequent experiments demonstrated that this abnormality on conflict trials was not due to a failure in distinguishing the contexts. Rather, these data reveal the selective involvement of the rat retrosplenial cortex in response conflict, and so extend the frontal system underlying cognitive control.
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  Label: Abstractor
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  Data: As Provided
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  Data: 45
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  Data: 2014
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