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Maternal Exposure to Occupational Asthmagens during Pregnancy and Autism Spectrum Disorder in the Study to Explore Early Development

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Title: Maternal Exposure to Occupational Asthmagens during Pregnancy and Autism Spectrum Disorder in the Study to Explore Early Development
Language: English
Authors: Singer, Alison B., Windham, Gayle C., Croen, Lisa A., Daniels, Julie L., Lee, Brian K., Qian, Yinge, Schendel, Diana E., Fallin, M. Daniele, Burstyn, Igor
Source: Journal of Autism and Developmental Disorders. Nov 2016 46(11):3458-3468.
Availability: Springer. 233 Spring Street, New York, NY 10013. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-348-4505; e-mail: service-ny@springer.com; Web site: http://www.springerlink.com
Peer Reviewed: Y
Page Count: 11
Publication Date: 2016
Sponsoring Agency: National Institute of Environmental Health Sciences (NIEHS) (NIH)
Centers for Disease Control and Prevention (DHHS/PHS)
Contract Number: T32ES007018
U10DD000180
U10DD000181
U10DD000182
U10DD000183
U10DD000184
U10DD000498
Document Type: Journal Articles
Reports - Research
Descriptors: Autism, Pervasive Developmental Disorders, Mothers, Prenatal Influences, Diseases, At Risk Persons, Hazardous Materials, Work Environment, Young Children, Developmental Disabilities, Cognitive Ability, Motor Development, Observation, Diagnostic Tests, Interviews, Coding, Statistical Analysis, Individual Characteristics, Correlation, Regression (Statistics)
Geographic Terms: California, Colorado, Georgia, Maryland, North Carolina, Pennsylvania
Assessment and Survey Identifiers: Mullen Scales of Early Learning, Autism Diagnostic Observation Schedule
DOI: 10.1007/s10803-016-2882-6
ISSN: 0162-3257
Abstract: Maternal immune activity has been linked to children with autism spectrum disorder (ASD). We examined maternal occupational exposure to asthma-causing agents during pregnancy in relation to ASD risk. Our sample included 463 ASD cases and 710 general population controls from the Study to Explore Early Development whose mothers reported at least one job during pregnancy. Asthmagen exposure was estimated from a published job-exposure matrix. The adjusted odds ratio for ASD comparing asthmagen-exposed to unexposed was 1.39 (95 % CI 0.96-2.02). Maternal workplace asthmagen exposure was not associated with ASD risk in this study, but this result does not exclude some involvement of maternal exposure to asthma-causing agents in ASD.
Abstractor: As Provided
Number of References: 51
Entry Date: 2016
Accession Number: EJ1117523
Database: ERIC
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  Data: Maternal Exposure to Occupational Asthmagens during Pregnancy and Autism Spectrum Disorder in the Study to Explore Early Development
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  Data: <searchLink fieldCode="SO" term="%22Journal+of+Autism+and+Developmental+Disorders%22"><i>Journal of Autism and Developmental Disorders</i></searchLink>. Nov 2016 46(11):3458-3468.
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  Data: Springer. 233 Spring Street, New York, NY 10013. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-348-4505; e-mail: service-ny@springer.com; Web site: http://www.springerlink.com
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  Data: Maternal immune activity has been linked to children with autism spectrum disorder (ASD). We examined maternal occupational exposure to asthma-causing agents during pregnancy in relation to ASD risk. Our sample included 463 ASD cases and 710 general population controls from the Study to Explore Early Development whose mothers reported at least one job during pregnancy. Asthmagen exposure was estimated from a published job-exposure matrix. The adjusted odds ratio for ASD comparing asthmagen-exposed to unexposed was 1.39 (95 % CI 0.96-2.02). Maternal workplace asthmagen exposure was not associated with ASD risk in this study, but this result does not exclude some involvement of maternal exposure to asthma-causing agents in ASD.
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        Value: 10.1007/s10803-016-2882-6
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