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A Causal and Mediation Analysis of the Comorbidity between Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD)

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Title: A Causal and Mediation Analysis of the Comorbidity between Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD)
Language: English
Authors: Sokolova, Elena, Oerlemans, Anoek M., Rommelse, Nanda N., Groot, Perry, Hartman, Catharina A., Glennon, Jeffrey C., Claassen, Tom, Heskes, Tom, Buitelaar, Jan K.
Source: Journal of Autism and Developmental Disorders. Jun 2017 47(6):1595-1604.
Availability: Springer. 233 Spring Street, New York, NY 10013. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-348-4505; e-mail: service-ny@springer.com; Web site: http://www.springerlink.com
Peer Reviewed: Y
Page Count: 10
Publication Date: 2017
Sponsoring Agency: National Institute of Mental Health (DHHS/NIH)
Contract Number: R01MH6287301A1
Document Type: Journal Articles
Reports - Research
Descriptors: Autism, Pervasive Developmental Disorders, Causal Models, Mediation Theory, Attention Deficit Hyperactivity Disorder, Comorbidity, Symptoms (Individual Disorders), Children, Siblings, Structural Equation Models, Self Control, Behavior Problems, Repetition, Attention Control, Comprehension, Verbal Ability, Intelligence Quotient, Physiology, Interpersonal Competence
DOI: 10.1007/s10803-017-3083-7
ISSN: 0162-3257
Abstract: Autism spectrum disorder (ASD) and Attention-deficit/hyperactivity disorder (ADHD) are often comorbid. The purpose of this study is to explore the relationships between ASD and ADHD symptoms by applying causal modeling. We used a large phenotypic data set of 417 children with ASD and/or ADHD, 562 affected and unaffected siblings, and 414 controls, to infer a structural equation model using a causal discovery algorithm. Three distinct pathways between ASD and ADHD were identified: (1) from impulsivity to difficulties with understanding social information, (2) from hyperactivity to stereotypic, repetitive behavior, (3) a pairwise pathway between inattention, difficulties with understanding social information, and verbal IQ. These findings may inform future studies on understanding the pathophysiological mechanisms behind the overlap between ASD and ADHD.
Abstractor: As Provided
Number of References: 56
Entry Date: 2017
Accession Number: EJ1141315
Database: ERIC
FullText Links:
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  Data: A Causal and Mediation Analysis of the Comorbidity between Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD)
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  Data: <searchLink fieldCode="AR" term="%22Sokolova%2C+Elena%22">Sokolova, Elena</searchLink><br /><searchLink fieldCode="AR" term="%22Oerlemans%2C+Anoek+M%2E%22">Oerlemans, Anoek M.</searchLink><br /><searchLink fieldCode="AR" term="%22Rommelse%2C+Nanda+N%2E%22">Rommelse, Nanda N.</searchLink><br /><searchLink fieldCode="AR" term="%22Groot%2C+Perry%22">Groot, Perry</searchLink><br /><searchLink fieldCode="AR" term="%22Hartman%2C+Catharina+A%2E%22">Hartman, Catharina A.</searchLink><br /><searchLink fieldCode="AR" term="%22Glennon%2C+Jeffrey+C%2E%22">Glennon, Jeffrey C.</searchLink><br /><searchLink fieldCode="AR" term="%22Claassen%2C+Tom%22">Claassen, Tom</searchLink><br /><searchLink fieldCode="AR" term="%22Heskes%2C+Tom%22">Heskes, Tom</searchLink><br /><searchLink fieldCode="AR" term="%22Buitelaar%2C+Jan+K%2E%22">Buitelaar, Jan K.</searchLink>
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  Data: <searchLink fieldCode="SO" term="%22Journal+of+Autism+and+Developmental+Disorders%22"><i>Journal of Autism and Developmental Disorders</i></searchLink>. Jun 2017 47(6):1595-1604.
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  Data: Springer. 233 Spring Street, New York, NY 10013. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-348-4505; e-mail: service-ny@springer.com; Web site: http://www.springerlink.com
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  Data: <searchLink fieldCode="DE" term="%22Autism%22">Autism</searchLink><br /><searchLink fieldCode="DE" term="%22Pervasive+Developmental+Disorders%22">Pervasive Developmental Disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Causal+Models%22">Causal Models</searchLink><br /><searchLink fieldCode="DE" term="%22Mediation+Theory%22">Mediation Theory</searchLink><br /><searchLink fieldCode="DE" term="%22Attention+Deficit+Hyperactivity+Disorder%22">Attention Deficit Hyperactivity Disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Comorbidity%22">Comorbidity</searchLink><br /><searchLink fieldCode="DE" term="%22Symptoms+%28Individual+Disorders%29%22">Symptoms (Individual Disorders)</searchLink><br /><searchLink fieldCode="DE" term="%22Children%22">Children</searchLink><br /><searchLink fieldCode="DE" term="%22Siblings%22">Siblings</searchLink><br /><searchLink fieldCode="DE" term="%22Structural+Equation+Models%22">Structural Equation Models</searchLink><br /><searchLink fieldCode="DE" term="%22Self+Control%22">Self Control</searchLink><br /><searchLink fieldCode="DE" term="%22Behavior+Problems%22">Behavior Problems</searchLink><br /><searchLink fieldCode="DE" term="%22Repetition%22">Repetition</searchLink><br /><searchLink fieldCode="DE" term="%22Attention+Control%22">Attention Control</searchLink><br /><searchLink fieldCode="DE" term="%22Comprehension%22">Comprehension</searchLink><br /><searchLink fieldCode="DE" term="%22Verbal+Ability%22">Verbal Ability</searchLink><br /><searchLink fieldCode="DE" term="%22Intelligence+Quotient%22">Intelligence Quotient</searchLink><br /><searchLink fieldCode="DE" term="%22Physiology%22">Physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Interpersonal+Competence%22">Interpersonal Competence</searchLink>
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  Data: Autism spectrum disorder (ASD) and Attention-deficit/hyperactivity disorder (ADHD) are often comorbid. The purpose of this study is to explore the relationships between ASD and ADHD symptoms by applying causal modeling. We used a large phenotypic data set of 417 children with ASD and/or ADHD, 562 affected and unaffected siblings, and 414 controls, to infer a structural equation model using a causal discovery algorithm. Three distinct pathways between ASD and ADHD were identified: (1) from impulsivity to difficulties with understanding social information, (2) from hyperactivity to stereotypic, repetitive behavior, (3) a pairwise pathway between inattention, difficulties with understanding social information, and verbal IQ. These findings may inform future studies on understanding the pathophysiological mechanisms behind the overlap between ASD and ADHD.
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  Data: 2017
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  Data: EJ1141315
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=eric&AN=EJ1141315
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        Value: 10.1007/s10803-017-3083-7
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      – Text: English
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    Subjects:
      – SubjectFull: Autism
        Type: general
      – SubjectFull: Pervasive Developmental Disorders
        Type: general
      – SubjectFull: Causal Models
        Type: general
      – SubjectFull: Mediation Theory
        Type: general
      – SubjectFull: Attention Deficit Hyperactivity Disorder
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      – SubjectFull: Comorbidity
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      – SubjectFull: Symptoms (Individual Disorders)
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      – SubjectFull: Children
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      – SubjectFull: Siblings
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      – SubjectFull: Structural Equation Models
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      – SubjectFull: Self Control
        Type: general
      – SubjectFull: Behavior Problems
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      – SubjectFull: Repetition
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      – SubjectFull: Attention Control
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      – SubjectFull: Comprehension
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      – TitleFull: A Causal and Mediation Analysis of the Comorbidity between Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD)
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