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The Nucleus Reuniens of the Thalamus Sits at the Nexus of a Hippocampus and Medial Prefrontal Cortex Circuit Enabling Memory and Behavior

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Title: The Nucleus Reuniens of the Thalamus Sits at the Nexus of a Hippocampus and Medial Prefrontal Cortex Circuit Enabling Memory and Behavior
Language: English
Authors: Dolleman-van der Weel, Margriet J., Griffin, Amy L., Ito, Hiroshi T., Shapiro, Matthew L., Witter, Menno P., Vertes, Robert P., Allen, Timothy A.
Source: Learning & Memory. Jul 2019 26(7):191-205.
Availability: Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org
Peer Reviewed: Y
Page Count: 15
Publication Date: 2019
Sponsoring Agency: National Institutes of Health (DHHS)
Contract Number: R01MH102394
R01MH113626
R15NS108259
Document Type: Journal Articles
Reports - Research
Descriptors: Brain Hemisphere Functions, Neurological Impairments, Anatomy, Physiology, Animals, Neurological Organization, Memory, Spatial Ability, Executive Function
DOI: 10.1101/lm.048389.118
ISSN: 1072-0502
Abstract: The nucleus reuniens of the thalamus (RE) is a key component of an extensive network of hippocampal and cortical structures and is a fundamental substrate for cognition. A common misconception is that RE is a simple relay structure. Instead, a better conceptualization is that RE is a critical component of a canonical higher-order cortico-thalamo-cortical circuit that supports communication between the medial prefrontal cortex (mPFC) and the hippocampus (HC). RE dysfunction is implicated in several clinical disorders including, but not limited to Alzheimer's disease, schizophrenia, and epilepsy. Here, we review key anatomical and physiological features of the RE based primarily on studies in rodents. We present a conceptual model of RE circuitry within the mPFC-RE-HC system and speculate on the computations RE enables. We review the rapidly growing literature demonstrating that RE is critical to, and its neurons represent, aspects of behavioral tasks that place demands on memory focusing on its role in navigation, spatial working memory, the temporal organization of memory, and executive functions.
Abstractor: As Provided
Entry Date: 2019
Accession Number: EJ1220804
Database: ERIC
FullText Text:
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  Data: The Nucleus Reuniens of the Thalamus Sits at the Nexus of a Hippocampus and Medial Prefrontal Cortex Circuit Enabling Memory and Behavior
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  Data: <searchLink fieldCode="AR" term="%22Dolleman-van+der+Weel%2C+Margriet+J%2E%22">Dolleman-van der Weel, Margriet J.</searchLink><br /><searchLink fieldCode="AR" term="%22Griffin%2C+Amy+L%2E%22">Griffin, Amy L.</searchLink><br /><searchLink fieldCode="AR" term="%22Ito%2C+Hiroshi+T%2E%22">Ito, Hiroshi T.</searchLink><br /><searchLink fieldCode="AR" term="%22Shapiro%2C+Matthew+L%2E%22">Shapiro, Matthew L.</searchLink><br /><searchLink fieldCode="AR" term="%22Witter%2C+Menno+P%2E%22">Witter, Menno P.</searchLink><br /><searchLink fieldCode="AR" term="%22Vertes%2C+Robert+P%2E%22">Vertes, Robert P.</searchLink><br /><searchLink fieldCode="AR" term="%22Allen%2C+Timothy+A%2E%22">Allen, Timothy A.</searchLink>
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  Data: <searchLink fieldCode="SO" term="%22Learning+%26+Memory%22"><i>Learning & Memory</i></searchLink>. Jul 2019 26(7):191-205.
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  Data: Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org
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  Data: 10.1101/lm.048389.118
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– Name: Abstract
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  Data: The nucleus reuniens of the thalamus (RE) is a key component of an extensive network of hippocampal and cortical structures and is a fundamental substrate for cognition. A common misconception is that RE is a simple relay structure. Instead, a better conceptualization is that RE is a critical component of a canonical higher-order cortico-thalamo-cortical circuit that supports communication between the medial prefrontal cortex (mPFC) and the hippocampus (HC). RE dysfunction is implicated in several clinical disorders including, but not limited to Alzheimer's disease, schizophrenia, and epilepsy. Here, we review key anatomical and physiological features of the RE based primarily on studies in rodents. We present a conceptual model of RE circuitry within the mPFC-RE-HC system and speculate on the computations RE enables. We review the rapidly growing literature demonstrating that RE is critical to, and its neurons represent, aspects of behavioral tasks that place demands on memory focusing on its role in navigation, spatial working memory, the temporal organization of memory, and executive functions.
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