Cognitive and Language Development at Age 4-6 Years in Children HIV-Exposed but Uninfected Compared to Those HIV-Unexposed and to Children Living with HIV
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| Title: | Cognitive and Language Development at Age 4-6 Years in Children HIV-Exposed but Uninfected Compared to Those HIV-Unexposed and to Children Living with HIV |
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| Language: | English |
| Authors: | Gruver, Rachel S. (ORCID |
| Source: | New Directions for Child and Adolescent Development. May 2020 (171):39-54. |
| Availability: | Wiley. Available from: John Wiley & Sons, Inc. 111 River Street, Hoboken, NJ 07030. Tel: 800-835-6770; e-mail: cs-journals@wiley.com; Web site: https://www.wiley.com/en-us |
| Peer Reviewed: | Y |
| Page Count: | 16 |
| Publication Date: | 2020 |
| Sponsoring Agency: | National Institute on Drug Abuse (NIDA) (DHHS/PHS) National Institutes of Health (DHHS), Fogarty International Center |
| Contract Number: | R01DA023697 |
| Document Type: | Journal Articles Reports - Research |
| Descriptors: | Acquired Immunodeficiency Syndrome (AIDS), Preschool Children, Child Development, Scores, Intelligence Tests, Language Impairments, Language Acquisition, Perinatal Influences, Comparative Analysis, Foreign Countries, Diagnostic Tests, Case Studies, Parent Child Relationship, Mothers, Prevention |
| Geographic Terms: | South Africa |
| Assessment and Survey Identifiers: | Kaufman Assessment Battery for Children, Reynell Developmental Language Scales |
| DOI: | 10.1002/cad.20351 |
| ISSN: | 1520-3247 |
| Abstract: | Perinatal HIV infection is associated with delayed neurocognitive development, but less is known about children perinatally HIV-exposed but uninfected (CHEU). We compared cognitive and language outcomes in 4-6-year old CHEU versus children HIV-unexposed and uninfected (CHUU) and children living with HIV (CLHIV). We enrolled 1,581 children (77% of the child population) in five communities in KwaZulu-Natal, South Africa. Children completed: Grover-Counter Scale of cognitive development, sub-scales of the Kaufman Assessment Battery for Children, Reynell Developmental Language Scales. HIV status of children and primary caregivers was determined by repeated rapid tests or report of prior testing. We conducted a cross-sectional multivariable linear regression on 922 dyads with complete data (257 CHEU, 627 CHUU, 38 CLHIV). On all outcome measures, CHEU and CHUU groups had comparable scores; CLHIV scored significantly lower. Emerging global progress toward the elimination of vertical HIV transmission may not only reduce mortality, but also positively impact child development. |
| Abstractor: | As Provided |
| Entry Date: | 2020 |
| Accession Number: | EJ1265355 |
| Database: | ERIC |
| Abstract: | Perinatal HIV infection is associated with delayed neurocognitive development, but less is known about children perinatally HIV-exposed but uninfected (CHEU). We compared cognitive and language outcomes in 4-6-year old CHEU versus children HIV-unexposed and uninfected (CHUU) and children living with HIV (CLHIV). We enrolled 1,581 children (77% of the child population) in five communities in KwaZulu-Natal, South Africa. Children completed: Grover-Counter Scale of cognitive development, sub-scales of the Kaufman Assessment Battery for Children, Reynell Developmental Language Scales. HIV status of children and primary caregivers was determined by repeated rapid tests or report of prior testing. We conducted a cross-sectional multivariable linear regression on 922 dyads with complete data (257 CHEU, 627 CHUU, 38 CLHIV). On all outcome measures, CHEU and CHUU groups had comparable scores; CLHIV scored significantly lower. Emerging global progress toward the elimination of vertical HIV transmission may not only reduce mortality, but also positively impact child development. |
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| ISSN: | 1520-3247 |
| DOI: | 10.1002/cad.20351 |
