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Cognitive and Language Development at Age 4-6 Years in Children HIV-Exposed but Uninfected Compared to Those HIV-Unexposed and to Children Living with HIV

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Title: Cognitive and Language Development at Age 4-6 Years in Children HIV-Exposed but Uninfected Compared to Those HIV-Unexposed and to Children Living with HIV
Language: English
Authors: Gruver, Rachel S. (ORCID 0000-0002-0599-2219), Mall, Sumaya (ORCID 0000-0001-8430-368X), Kvalsvig, Jane D., Knox, Justin R. (ORCID 0000-0001-6771-8138), Mellins, Claude A., Desmond, Chris, Kauchali, Shuaib, Arpadi, Stephen M., Taylor, Myra, Davidson, Leslie L.
Source: New Directions for Child and Adolescent Development. May 2020 (171):39-54.
Availability: Wiley. Available from: John Wiley & Sons, Inc. 111 River Street, Hoboken, NJ 07030. Tel: 800-835-6770; e-mail: cs-journals@wiley.com; Web site: https://www.wiley.com/en-us
Peer Reviewed: Y
Page Count: 16
Publication Date: 2020
Sponsoring Agency: National Institute on Drug Abuse (NIDA) (DHHS/PHS)
National Institutes of Health (DHHS), Fogarty International Center
Contract Number: R01DA023697
Document Type: Journal Articles
Reports - Research
Descriptors: Acquired Immunodeficiency Syndrome (AIDS), Preschool Children, Child Development, Scores, Intelligence Tests, Language Impairments, Language Acquisition, Perinatal Influences, Comparative Analysis, Foreign Countries, Diagnostic Tests, Case Studies, Parent Child Relationship, Mothers, Prevention
Geographic Terms: South Africa
Assessment and Survey Identifiers: Kaufman Assessment Battery for Children, Reynell Developmental Language Scales
DOI: 10.1002/cad.20351
ISSN: 1520-3247
Abstract: Perinatal HIV infection is associated with delayed neurocognitive development, but less is known about children perinatally HIV-exposed but uninfected (CHEU). We compared cognitive and language outcomes in 4-6-year old CHEU versus children HIV-unexposed and uninfected (CHUU) and children living with HIV (CLHIV). We enrolled 1,581 children (77% of the child population) in five communities in KwaZulu-Natal, South Africa. Children completed: Grover-Counter Scale of cognitive development, sub-scales of the Kaufman Assessment Battery for Children, Reynell Developmental Language Scales. HIV status of children and primary caregivers was determined by repeated rapid tests or report of prior testing. We conducted a cross-sectional multivariable linear regression on 922 dyads with complete data (257 CHEU, 627 CHUU, 38 CLHIV). On all outcome measures, CHEU and CHUU groups had comparable scores; CLHIV scored significantly lower. Emerging global progress toward the elimination of vertical HIV transmission may not only reduce mortality, but also positively impact child development.
Abstractor: As Provided
Entry Date: 2020
Accession Number: EJ1265355
Database: ERIC
FullText Text:
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  Data: Cognitive and Language Development at Age 4-6 Years in Children HIV-Exposed but Uninfected Compared to Those HIV-Unexposed and to Children Living with HIV
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  Data: <searchLink fieldCode="AR" term="%22Gruver%2C+Rachel+S%2E%22">Gruver, Rachel S.</searchLink> (ORCID <externalLink term="https://orcid.org/0000-0002-0599-2219">0000-0002-0599-2219</externalLink>)<br /><searchLink fieldCode="AR" term="%22Mall%2C+Sumaya%22">Mall, Sumaya</searchLink> (ORCID <externalLink term="https://orcid.org/0000-0001-8430-368X">0000-0001-8430-368X</externalLink>)<br /><searchLink fieldCode="AR" term="%22Kvalsvig%2C+Jane+D%2E%22">Kvalsvig, Jane D.</searchLink><br /><searchLink fieldCode="AR" term="%22Knox%2C+Justin+R%2E%22">Knox, Justin R.</searchLink> (ORCID <externalLink term="https://orcid.org/0000-0001-6771-8138">0000-0001-6771-8138</externalLink>)<br /><searchLink fieldCode="AR" term="%22Mellins%2C+Claude+A%2E%22">Mellins, Claude A.</searchLink><br /><searchLink fieldCode="AR" term="%22Desmond%2C+Chris%22">Desmond, Chris</searchLink><br /><searchLink fieldCode="AR" term="%22Kauchali%2C+Shuaib%22">Kauchali, Shuaib</searchLink><br /><searchLink fieldCode="AR" term="%22Arpadi%2C+Stephen+M%2E%22">Arpadi, Stephen M.</searchLink><br /><searchLink fieldCode="AR" term="%22Taylor%2C+Myra%22">Taylor, Myra</searchLink><br /><searchLink fieldCode="AR" term="%22Davidson%2C+Leslie+L%2E%22">Davidson, Leslie L.</searchLink>
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  Data: <searchLink fieldCode="SO" term="%22New+Directions+for+Child+and+Adolescent+Development%22"><i>New Directions for Child and Adolescent Development</i></searchLink>. May 2020 (171):39-54.
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  Data: Wiley. Available from: John Wiley & Sons, Inc. 111 River Street, Hoboken, NJ 07030. Tel: 800-835-6770; e-mail: cs-journals@wiley.com; Web site: https://www.wiley.com/en-us
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  Data: Y
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  Data: 16
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  Label: Publication Date
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  Data: 2020
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  Label: Sponsoring Agency
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  Data: National Institute on Drug Abuse (NIDA) (DHHS/PHS)<br />National Institutes of Health (DHHS), Fogarty International Center
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  Data: R01DA023697
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  Data: Journal Articles<br />Reports - Research
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  Data: <searchLink fieldCode="DE" term="%22Acquired+Immunodeficiency+Syndrome+%28AIDS%29%22">Acquired Immunodeficiency Syndrome (AIDS)</searchLink><br /><searchLink fieldCode="DE" term="%22Preschool+Children%22">Preschool Children</searchLink><br /><searchLink fieldCode="DE" term="%22Child+Development%22">Child Development</searchLink><br /><searchLink fieldCode="DE" term="%22Scores%22">Scores</searchLink><br /><searchLink fieldCode="DE" term="%22Intelligence+Tests%22">Intelligence Tests</searchLink><br /><searchLink fieldCode="DE" term="%22Language+Impairments%22">Language Impairments</searchLink><br /><searchLink fieldCode="DE" term="%22Language+Acquisition%22">Language Acquisition</searchLink><br /><searchLink fieldCode="DE" term="%22Perinatal+Influences%22">Perinatal Influences</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+Analysis%22">Comparative Analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Foreign+Countries%22">Foreign Countries</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnostic+Tests%22">Diagnostic Tests</searchLink><br /><searchLink fieldCode="DE" term="%22Case+Studies%22">Case Studies</searchLink><br /><searchLink fieldCode="DE" term="%22Parent+Child+Relationship%22">Parent Child Relationship</searchLink><br /><searchLink fieldCode="DE" term="%22Mothers%22">Mothers</searchLink><br /><searchLink fieldCode="DE" term="%22Prevention%22">Prevention</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22South+Africa%22">South Africa</searchLink>
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  Label: Assessment and Survey Identifiers
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  Data: <searchLink fieldCode="SU" term="%22Kaufman+Assessment+Battery+for+Children%22">Kaufman Assessment Battery for Children</searchLink><br /><searchLink fieldCode="SU" term="%22Reynell+Developmental+Language+Scales%22">Reynell Developmental Language Scales</searchLink>
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  Data: 10.1002/cad.20351
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  Data: 1520-3247
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Perinatal HIV infection is associated with delayed neurocognitive development, but less is known about children perinatally HIV-exposed but uninfected (CHEU). We compared cognitive and language outcomes in 4-6-year old CHEU versus children HIV-unexposed and uninfected (CHUU) and children living with HIV (CLHIV). We enrolled 1,581 children (77% of the child population) in five communities in KwaZulu-Natal, South Africa. Children completed: Grover-Counter Scale of cognitive development, sub-scales of the Kaufman Assessment Battery for Children, Reynell Developmental Language Scales. HIV status of children and primary caregivers was determined by repeated rapid tests or report of prior testing. We conducted a cross-sectional multivariable linear regression on 922 dyads with complete data (257 CHEU, 627 CHUU, 38 CLHIV). On all outcome measures, CHEU and CHUU groups had comparable scores; CLHIV scored significantly lower. Emerging global progress toward the elimination of vertical HIV transmission may not only reduce mortality, but also positively impact child development.
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  Data: 2020
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  Data: EJ1265355
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      – SubjectFull: Acquired Immunodeficiency Syndrome (AIDS)
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      – SubjectFull: Preschool Children
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      – SubjectFull: Child Development
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      – SubjectFull: Scores
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      – SubjectFull: Intelligence Tests
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      – SubjectFull: Language Impairments
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      – SubjectFull: Comparative Analysis
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      – SubjectFull: Foreign Countries
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