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Octopaminergic Neurons Have Multiple Targets in 'Drosophila' Larval Mushroom Body Calyx and Can Modulate Behavioral Odor Discrimination

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Title: Octopaminergic Neurons Have Multiple Targets in 'Drosophila' Larval Mushroom Body Calyx and Can Modulate Behavioral Odor Discrimination
Language: English
Authors: Wong, J. Y. Hilary, Wan, Bo Angela, Bland, Tom, Montagnese, Marcella, McLachlan, Alex D., O'Kane, Cahir J., Zhang, Shuo Wei, Masuda-Nakagawa, Liria M. (ORCID 0000-0002-2504-3379)
Source: Learning & Memory. Feb 2021 28(2):53-71.
Availability: Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org
Peer Reviewed: Y
Page Count: 19
Publication Date: 2021
Document Type: Journal Articles
Reports - Research
Descriptors: Human Body, Olfactory Perception, Animal Behavior, Memory, Brain Hemisphere Functions, Inhibition, Cytology, Learning Processes, Sensory Experience
DOI: 10.1101/lm.052159.120
ISSN: 1072-0502
Abstract: Discrimination of sensory signals is essential for an organism to form and retrieve memories of relevance in a given behavioral context. Sensory representations are modified dynamically by changes in behavioral state, facilitating context-dependent selection of behavior, through signals carried by noradrenergic input in mammals, or octopamine (OA) in insects. To understand the circuit mechanisms of this signaling, we characterized the function of two OA neurons, sVUM1 neurons, that originate in the subesophageal zone (SEZ) and target the input region of the memory center, the mushroom body (MB) calyx, in larval "Drosophila." We found that sVUM1 neurons target multiple neurons, including olfactory projection neurons (PNs), the inhibitory neuron APL, and a pair of extrinsic output neurons, but relatively few mushroom body intrinsic neurons, Kenyon cells. PN terminals carried the OA receptor Oamb, a "Drosophila" [alpha]1-adrenergic receptor ortholog. Using an odor discrimination learning paradigm, we showed that optogenetic activation of OA neurons compromised discrimination of similar odors but not learning ability. Our results suggest that sVUM1 neurons modify odor representations via multiple extrinsic inputs at the sensory input area to the MB olfactory learning circuit.
Abstractor: As Provided
Entry Date: 2021
Accession Number: EJ1284990
Database: ERIC
FullText Text:
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  Data: Octopaminergic Neurons Have Multiple Targets in 'Drosophila' Larval Mushroom Body Calyx and Can Modulate Behavioral Odor Discrimination
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  Data: <searchLink fieldCode="AR" term="%22Wong%2C+J%2E+Y%2E+Hilary%22">Wong, J. Y. Hilary</searchLink><br /><searchLink fieldCode="AR" term="%22Wan%2C+Bo+Angela%22">Wan, Bo Angela</searchLink><br /><searchLink fieldCode="AR" term="%22Bland%2C+Tom%22">Bland, Tom</searchLink><br /><searchLink fieldCode="AR" term="%22Montagnese%2C+Marcella%22">Montagnese, Marcella</searchLink><br /><searchLink fieldCode="AR" term="%22McLachlan%2C+Alex+D%2E%22">McLachlan, Alex D.</searchLink><br /><searchLink fieldCode="AR" term="%22O'Kane%2C+Cahir+J%2E%22">O'Kane, Cahir J.</searchLink><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Shuo+Wei%22">Zhang, Shuo Wei</searchLink><br /><searchLink fieldCode="AR" term="%22Masuda-Nakagawa%2C+Liria+M%2E%22">Masuda-Nakagawa, Liria M.</searchLink> (ORCID <externalLink term="https://orcid.org/0000-0002-2504-3379">0000-0002-2504-3379</externalLink>)
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  Data: <searchLink fieldCode="SO" term="%22Learning+%26+Memory%22"><i>Learning & Memory</i></searchLink>. Feb 2021 28(2):53-71.
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  Data: Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org
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  Data: 10.1101/lm.052159.120
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  Data: 1072-0502
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  Data: Discrimination of sensory signals is essential for an organism to form and retrieve memories of relevance in a given behavioral context. Sensory representations are modified dynamically by changes in behavioral state, facilitating context-dependent selection of behavior, through signals carried by noradrenergic input in mammals, or octopamine (OA) in insects. To understand the circuit mechanisms of this signaling, we characterized the function of two OA neurons, sVUM1 neurons, that originate in the subesophageal zone (SEZ) and target the input region of the memory center, the mushroom body (MB) calyx, in larval "Drosophila." We found that sVUM1 neurons target multiple neurons, including olfactory projection neurons (PNs), the inhibitory neuron APL, and a pair of extrinsic output neurons, but relatively few mushroom body intrinsic neurons, Kenyon cells. PN terminals carried the OA receptor Oamb, a "Drosophila" [alpha]1-adrenergic receptor ortholog. Using an odor discrimination learning paradigm, we showed that optogenetic activation of OA neurons compromised discrimination of similar odors but not learning ability. Our results suggest that sVUM1 neurons modify odor representations via multiple extrinsic inputs at the sensory input area to the MB olfactory learning circuit.
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