Cognitive and Electrophysiological Correlates of Working Memory Impairments in Neurofibromatosis Type 1
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| Title: | Cognitive and Electrophysiological Correlates of Working Memory Impairments in Neurofibromatosis Type 1 |
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| Language: | English |
| Authors: | Pobric, Gorana, Taylor, Jason R., Ramalingam, Hemavathy M., Pye, Emily, Robinson, Louise, Vassallo, Grace, Jung, JeYoung, Bhandary, Misty, Szumanska-Ryt, Karolina, Theodosiou, Louise, Evans, D. Gareth, Eelloo, Judith, Burkitt-Wright, Emma, Hulleman, Johan, Green, Jonathan, Garg, Shruti (ORCID |
| Source: | Journal of Autism and Developmental Disorders. Apr 2022 52(4):1478-1494. |
| Availability: | Springer. Available from: Springer Nature. One New York Plaza, Suite 4600, New York, NY 10004. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-460-1700; e-mail: customerservice@springernature.com; Web site: https://link.springer.com/ |
| Peer Reviewed: | Y |
| Page Count: | 17 |
| Publication Date: | 2022 |
| Document Type: | Journal Articles Reports - Research |
| Descriptors: | Short Term Memory, Neurological Impairments, Genetic Disorders, Adolescents, Cognitive Processes, Medicine |
| DOI: | 10.1007/s10803-021-05043-3 |
| ISSN: | 0162-3257 |
| Abstract: | Neurofibromatosis 1 (NF1) is a single gene disorder associated with working Memory (WM) impairments. The aim of this study was to investigate P300 event-related potential (ERP) associated with WM in NF1. Sixteen adolescents with NF1 were compared with controls on measures of WM and EEG was recorded during a WM nback task. The NF1 group showed poorer performance on measures of WM as compared to the control group. No group differences were observed in P300 amplitude at Pz, but P300 latency was shorter in the NF1 group. Topographic analyses of P300 amplitude showed group differences indicating neural processing differences in the NF1 group relative to controls, which possibly contribute to the cognitive deficits seen in this population. |
| Abstractor: | As Provided |
| Entry Date: | 2022 |
| Accession Number: | EJ1330283 |
| Database: | ERIC |
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