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Timing and Intertemporal Choice Behavior in the Valproic Acid Rat Model of Autism Spectrum Disorder

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Bibliographic Details
Title: Timing and Intertemporal Choice Behavior in the Valproic Acid Rat Model of Autism Spectrum Disorder
Language: English
Authors: DeCoteau, William E., Fox, Adam E. (ORCID 0000-0001-8507-1008)
Source: Journal of Autism and Developmental Disorders. Jun 2022 52(6):2414-2429.
Availability: Springer. Available from: Springer Nature. One New York Plaza, Suite 4600, New York, NY 10004. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-460-1700; e-mail: customerservice@springernature.com; Web site: https://link.springer.com/
Peer Reviewed: Y
Page Count: 16
Publication Date: 2022
Document Type: Journal Articles
Reports - Research
Descriptors: Autism, Pervasive Developmental Disorders, Time Perspective, Animals, Motor Reactions, Intervals, Animal Behavior, Anxiety, Memory, Persistence
DOI: 10.1007/s10803-021-05129-y
ISSN: 0162-3257
Abstract: Recently it has been proposed that impairments related to autism spectrum disorder (ASD) may reflect a more fundamental disruption in time perception. Here, we examined whether in utero exposure to valproic acid (VPA) can generate specific behavioral deficits related to ASD and time perception. Pups from control and VPA groups were tested using fixed-interval (FI) temporal bisection, peak interval, and intertemporal choice tasks. In addition, the rats were assessed on motor function, perseverative and exploratory behavior, anxiety, and memory. The VPA group displayed a leftward shift in timing functions. VPA rats displayed no deficits on the motor and memory tasks, but were significantly different from controls on measures of perseveration and anxiety.
Abstractor: As Provided
Entry Date: 2022
Accession Number: EJ1335893
Database: ERIC
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Description
Abstract:Recently it has been proposed that impairments related to autism spectrum disorder (ASD) may reflect a more fundamental disruption in time perception. Here, we examined whether in utero exposure to valproic acid (VPA) can generate specific behavioral deficits related to ASD and time perception. Pups from control and VPA groups were tested using fixed-interval (FI) temporal bisection, peak interval, and intertemporal choice tasks. In addition, the rats were assessed on motor function, perseverative and exploratory behavior, anxiety, and memory. The VPA group displayed a leftward shift in timing functions. VPA rats displayed no deficits on the motor and memory tasks, but were significantly different from controls on measures of perseveration and anxiety.
ISSN:0162-3257
DOI:10.1007/s10803-021-05129-y