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Abnormal Structural and Functional Connectivity of the Corpus Callosum in Autism Spectrum Disorders: A Review

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Title: Abnormal Structural and Functional Connectivity of the Corpus Callosum in Autism Spectrum Disorders: A Review
Language: English
Authors: Marco Valenti, Maria Chiara Pino (ORCID 0000-0003-2657-2122), Monica Mazza, Gianvito Panzarino, Claudio Di Paolantonio, Alberto Verrotti
Source: Review Journal of Autism and Developmental Disorders. 2020 7(1):46-62.
Availability: Springer. Available from: Springer Nature. One New York Plaza, Suite 4600, New York, NY 10004. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-460-1700; e-mail: customerservice@springernature.com; Web site: https://link.springer.com/
Peer Reviewed: Y
Page Count: 17
Publication Date: 2020
Document Type: Journal Articles
Information Analyses
Descriptors: Autism Spectrum Disorders, Brain, Brain Hemisphere Functions, Social Cognition, Short Term Memory, Executive Function, Neurological Impairments
DOI: 10.1007/s40489-019-00176-9
ISSN: 2195-7177
2195-7185
Abstract: Autism spectrum disorder (ASD) is characterised by difficulties with social communication, interaction, and repetitive and stereotypical patterns of behaviour. Recent studies suggest that abnormalities in the corpus callosum (CC) can produce autistic symptoms, so this cerebral structure is a target for autism research. It is the largest area of white matter fibre that connects the cerebral hemispheres and has been considered an index of interhemispheric connectivity. The poor connectivity that is a characteristic of autism could be due to CC abnormalities. In this review, we describe empirical studies that have used functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) to investigate the role of the CC in functional and structural brain connectivity in individuals with ASD. Establishing the anatomical correlates of abnormal connectivity in ASD is a major objective of structural and functional connectivity studies. Reduced CC volume is one of the most consistent findings in studies of autistic brains. Structural connectivity studies have shown that the CC is generally altered in ASD. In addition, functional connectivity studies show atypical activity in individuals with ASD during social cognition tasks, working memory tasks, and tests of executive function. Research on functional and structural connectivity has contributed to understanding the role of the CC in the clinical symptoms and social and cognitive deficits associated with ASD.
Abstractor: As Provided
Entry Date: 2024
Accession Number: EJ1422154
Database: ERIC
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  Data: <searchLink fieldCode="AR" term="%22Marco+Valenti%22">Marco Valenti</searchLink><br /><searchLink fieldCode="AR" term="%22Maria+Chiara+Pino%22">Maria Chiara Pino</searchLink> (ORCID <externalLink term="http://orcid.org/0000-0003-2657-2122">0000-0003-2657-2122</externalLink>)<br /><searchLink fieldCode="AR" term="%22Monica+Mazza%22">Monica Mazza</searchLink><br /><searchLink fieldCode="AR" term="%22Gianvito+Panzarino%22">Gianvito Panzarino</searchLink><br /><searchLink fieldCode="AR" term="%22Claudio+Di+Paolantonio%22">Claudio Di Paolantonio</searchLink><br /><searchLink fieldCode="AR" term="%22Alberto+Verrotti%22">Alberto Verrotti</searchLink>
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  Data: Springer. Available from: Springer Nature. One New York Plaza, Suite 4600, New York, NY 10004. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-460-1700; e-mail: customerservice@springernature.com; Web site: https://link.springer.com/
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  Data: Autism spectrum disorder (ASD) is characterised by difficulties with social communication, interaction, and repetitive and stereotypical patterns of behaviour. Recent studies suggest that abnormalities in the corpus callosum (CC) can produce autistic symptoms, so this cerebral structure is a target for autism research. It is the largest area of white matter fibre that connects the cerebral hemispheres and has been considered an index of interhemispheric connectivity. The poor connectivity that is a characteristic of autism could be due to CC abnormalities. In this review, we describe empirical studies that have used functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) to investigate the role of the CC in functional and structural brain connectivity in individuals with ASD. Establishing the anatomical correlates of abnormal connectivity in ASD is a major objective of structural and functional connectivity studies. Reduced CC volume is one of the most consistent findings in studies of autistic brains. Structural connectivity studies have shown that the CC is generally altered in ASD. In addition, functional connectivity studies show atypical activity in individuals with ASD during social cognition tasks, working memory tasks, and tests of executive function. Research on functional and structural connectivity has contributed to understanding the role of the CC in the clinical symptoms and social and cognitive deficits associated with ASD.
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